Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Terukatsu Sasaki"'
Autor:
Terukatsu, Sasaki
Publikováno v:
Tumor Research. 45:5-9
Autor:
Takashi Nakaoka, Toshihide Nishishita, Naohide Yamashita, Koichiro Kuwabara, Terukatsu Sasaki, Kaori Sato
Publikováno v:
Endocrinology. 145:3324-3330
Proline-rich tyrosine kinase 2 (Pyk2), a member of the focal adhesion kinase family, is thought to act as a key component in vasculogenesis and angiogenesis. Therefore, we studied the effect of mutant Pyk2 expression on the migration and proliferatio
Autor:
Kazuhiko Nishida, Hiroyuki Nakayama, Michio Asahi, Shungo Hikoso, Masatsugu Hori, Toshihiro Takeda, Tetsuya Watanabe, Yoshiharu Higuchi, Masayuki Taniike, Osamu Yamaguchi, Kazunori Kashiwase, Yasushi Matsumura, Ikuko Tsujimoto, Shinichi Hirotani, Kinya Otsu, Terukatsu Sasaki
Publikováno v:
Journal of Molecular and Cellular Cardiology. 36:799-807
G-protein-coupled receptor agonists including endothelin-1 (ET-1) and phenylephrine (PE) induce hypertrophy in neonatal ventricular cardiomyocytes. Others and we previously reported that Rac1 signaling pathway plays an important role in this agonist-
Publikováno v:
Oncogene. 23:5124-5130
Three of the Rad family proteins, Rad9, Rad1, and Hus1, can interact with each other and form a heterotrimeric complex that is thought to play a role in the sensing step of the DNA integrity checkpoint pathways, but the nature of the Rad9-Rad1-Hus1 c
Autor:
Terukatsu Sasaki, Gerald D. Frank, Motoi Ohba, Peter J. Dempsey, Shigeki Higashiyama, Mizuo Mifune, Tadashi Inagami, Satoru Eguchi
Publikováno v:
Molecular and Cellular Biology. 23:1581-1589
Reactive oxygen species (ROS) are implicated in cardiovascular diseases. ROS, such as H2O2, act as second messengers to activate diverse signaling pathways. Although H2O2 activates several tyrosine kinases, including the epidermal growth factor (EGF)
Autor:
Satoru Eguchi, Evangeline D. Motley, Shuichi Saito, Tadashi Inagami, Toshio Kuroki, Gerald D. Frank, Motoi Ohba, Terukatsu Sasaki
Publikováno v:
Molecular Endocrinology. 16:367-377
In vascular smooth muscle cells, angiotensin II (AngII) stimulates association of its G protein-coupled AngII type 1 (AT(1)) receptor with Janus kinase 2 (JAK2), resulting in the activation of signal transducer and activator of transcription proteins
Publikováno v:
Journal of Biological Chemistry. 277:5441-5447
Endothelial cell spreading, migration, and morphogenesis are essential for angiogenesis, the formation of new blood vessels. In the present study, we explored roles of tyrosine kinase Pyk2 in angiogenesis of pulmonary endothelial cells. We found that
Autor:
Yoshihisa Nojima, Chieko Takagi, Terukatsu Sasaki, Toshihiro Mitaka, Kazue Ueki, Yoriaki Kaneko, Yoshito Tsukada, Akira Maezawa, Takashi Kuroiwa, Hidekazu Ikeuchi
Publikováno v:
American Journal of Kidney Diseases. 39:174-182
Cell adhesion kinase β (CAKβ, also known as Pyk2/CadTK/RAFTK ) is the second member of the focal adhesion kinase (FAK) subfamily. We examined the expression of CAKβ in various human glomerulopathies by immunohistochemistry. Although CAKβ expressi
Publikováno v:
Biochemical and Biophysical Research Communications. 286:692-696
Activation of tyrosine kinases is believed to play a central role in angiotensin II (AngII) signaling. Here, we have investigated whether a tyrosine kinase, PYK2, is functionally involved in AngII-induced c-Jun N-terminal kinase (JNK) activation in v
Autor:
Hiroshi Aoto, John F. MacDonald, Declan W. Ali, Yue-Qiao Huang, John C. Roder, Michael W. Salter, Graham M. Pitcher, Kenneth A Pelkey, Wei-Yang Lu, You Ming Lu, Terukatsu Sasaki
Publikováno v:
Neuron. 29(2):485-496
Long-term potentiation (LTP) is an activity-dependent enhancement of synaptic efficacy, considered a model of learning and memory. The biochemical cascade producing LTP requires activation of Src, which upregulates the function of NMDA receptors (NMD