Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Teruaki Okuda"'
Autor:
Toshiaki Maruyama, Naosuke Kamei, Satoshi Ujigo, Teruaki Okuda, Taiki Morisako, Yuji Tsuchikawa, Hiroki Fukui, Takashi Hashimoto, Takeshi Hiramatsu, Takuro Shimbo, Kazuyoshi Nakanishi, Kiyotaka Yamada, Kjell Olmarker, Yoshinori Fujimoto, Nobuo Adachi, Toshio Nakamae
Publikováno v:
European Spine Journal. 30:2020-2032
Treatment of low back pain (LBP) associated with elderly degenerative lumbar scoliosis (DLS) remains controversial. We have developed percutaneous intervertebral-vacuum polymethylmethacrylate injection (PIPI) targeting to the intervertebral vacuum as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4cad42b8be72c0caf1efe2840b22a6
https://doi.org/10.1007/s00586-021-06805-4
https://doi.org/10.1007/s00586-021-06805-4
Autor:
Taisuke Katoh, Tomoya Sameshima, Masato Yoshikawa, Tomoya Yukawa, Hideto Hara, Takatoshi Yogo, Russell Naven, Makoto Miyamoto, Ikuo Miyahisa, Yoshihiko Hirozane, Teruaki Okuda
Publikováno v:
Chemical Research in Toxicology. 33:154-161
Despite the recent advances in the life sciences and the remarkable investment in drug discovery research, the success rate of small-molecule drug development remains low. Safety is the second most influential factor of drug attrition in clinical stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de95254694309472dcddfb7d08032ee3
https://doi.org/10.1021/acs.chemrestox.9b00128
https://doi.org/10.1021/acs.chemrestox.9b00128
Autor:
Etsuo Kotani, Kazuyoshi Aso, Yohei Kosugi, Mochizuki Michiyo, Takuto Kojima, Takahiko Yano, Maiko Tanaka, Teruaki Okuda, Yuu Sako, Hideyuki Nakagawa, Yuji Ishichi, Naoyuki Kanzaki, Katsumi Kobayashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1556-1570
Compound 1 exhibits potent binding inhibition activity against a corticotropin-releasing factor 1 (CRF1) receptor (IC50=9.5nM) and in vitro antagonistic activity (IC50=88nM) but is rapidly metabolized by human hepatic microsomes (182μL/min/mg). Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049814ad68ed4e97ee9152f6e5cc7752
https://doi.org/10.1016/j.bmc.2016.11.011
https://doi.org/10.1016/j.bmc.2016.11.011
Publikováno v:
Xenobiotica. 44:1135-1144
1. Recently, the Food and Drug Administration (FDA) and European Medicines Agency have shown decision trees to determine whether a drug candidate is an inhibitor of P-glycoprotein (P-gp). However, there has been no clear information on whether P-gp i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78060715d8b485e342891972bc21a71
https://doi.org/10.3109/00498254.2014.928958
https://doi.org/10.3109/00498254.2014.928958
Autor:
Yasushi Fujioka, Teruaki Okuda, Hideki Hirabayashi, Yohei Kosugi, Toshiya Moriwaki, Tomoko Igari
Publikováno v:
Xenobiotica. 44:336-344
1. This study optimized the reported approach for the prediction of drug-drug interactions (DDIs) using hepatocytes suspended in serum (HHSS) and provided a practical usage of HHSS in the early and late phases of drug discovery. 2. First, the IC50 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f9b9178127e319899ef52c2687cdd8
https://doi.org/10.3109/00498254.2013.837988
https://doi.org/10.3109/00498254.2013.837988
Autor:
Michiyo, Mochizuki, Takuto, Kojima, Katsumi, Kobayashi, Etsuo, Kotani, Yuji, Ishichi, Naoyuki, Kanzaki, Hideyuki, Nakagawa, Teruaki, Okuda, Yohei, Kosugi, Takahiko, Yano, Yuu, Sako, Maiko, Tanaka, Kazuyoshi, Aso
Publikováno v:
Bioorganicmedicinal chemistry. 25(5)
Compound 1 exhibits potent binding inhibition activity against a corticotropin-releasing factor 1 (CRF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::262d75fa1f92a91ba1d5c8adffd8d6e2
https://pubmed.ncbi.nlm.nih.gov/28174066
https://pubmed.ncbi.nlm.nih.gov/28174066
Autor:
Teruaki Okuda, Takashi Hashimoto, Nobuhiro Tanaka, Toshio Nakamae, Toshikatsu Kanazawa, Kiyotaka Yamada, Kjell Olmarker, Haruhiko Takata, Yoshinori Fujimoto, Takuro Shimbo, Takeshi Hiramatsu
Publikováno v:
Spine. 41(10)
STUDY DESIGN Prospective cohort study. OBJECTIVE To compare the novel treatment procedure with nonoperative treatment for low back pain (LBP) in elderly patients with degenerative lumbar scoliosis (DLS). SUMMARY OF BACKGROUND DATA Treatment of LBP as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bc940499a5e335f8a7fead2a7c1daf
https://pubmed.ncbi.nlm.nih.gov/26909842
https://pubmed.ncbi.nlm.nih.gov/26909842
Autor:
Takashi Hashimoto, Toshio Nakamae, Teruaki Okuda, Takuro Shimbo, Kiyotaka Yamada, Mitsuo Ochi, Yoshinori Fujimoto, Nobuhiro Tanaka, Takeshi Hiramatsu, Toshikatsu Kanazawa, Kjell Olmarker, Haruhiko Takata
Publikováno v:
Spine. 41(10)
STUDY DESIGN Cross-sectional study. OBJECTIVE To examine whether bone marrow edema is associated with low back pain in elderly patients with degenerative lumbar scoliosis. SUMMARY OF BACKGROUND DATA The cause of low back pain in degenerative lumbar s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f5b7f00575e19fb04885227aacf574
https://pubmed.ncbi.nlm.nih.gov/26641841
https://pubmed.ncbi.nlm.nih.gov/26641841
Autor:
Yohei Kosugi, Teruaki Okuda, Toshiya Moriwaki, Tomoko Igari, Yoko Hara, Yasushi Fujioka, Hideki Hirabayashi
Publikováno v:
Xenobiotica. 42:127-138
Herein, we aimed to evaluate the recently proposed risk assessment strategies of a cytochrome P450 (CYP) mediated drug-drug interaction (DDI) according to the European Medicines Evaluation Agency (EMEA) draft guideline, and discuss the differences be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b345a563a730b7a316d42f0d37deac8b
https://doi.org/10.3109/00498254.2011.626087
https://doi.org/10.3109/00498254.2011.626087
Autor:
Nobuyuki Matsunaga, Akihiro Tasaka, Satoru Asahi, Mari Adachi, Takahito Hara, Toshimasa Tanaka, Teruaki Okuda, Akio Ojida, Takenori Hitaka, Shuichi Furuya, Tomohiro Kaku, Masami Kusaka, Masuo Yamaoka
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6383-6399
A novel naphthylmethylimidazole derivative 1 and its related compounds were identified as 17,20-lyase inhibitors. Based on the structure–activity relationship around the naphthalene scaffold and the results of a docking study of 1a in the homology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9ae1020bfeecd91e9f7d00f654b7c3
https://doi.org/10.1016/j.bmc.2011.08.066
https://doi.org/10.1016/j.bmc.2011.08.066