Výsledky vyhledávání - "Teruaki Akao"

Involvement of the CYP1A Subfamily in Stereoselective Metabolism of Carvedilol in .BETA.-Naphthoflavone-Treated Caco-2 Cells

Autor: Masato Taguchi, Teruaki Akao, Kazuya Ishida, Yukiya Hashimoto

Publikováno v: Biological and Pharmaceutical Bulletin. 32:513-516

We have previously reported that the metabolism of S-carvedilol in beta-naphthoflavone (beta-NF)-treated Caco-2 cells is faster than that of R-carvedilol. The aim of the present study was to identify the enzyme responsible for the stereoselective met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25222a9b588025d26619d6f1adae477
https://doi.org/10.1248/bpb.32.513

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Isoliquiritigenin, One of the Antispasmodic Principles of Glycyrrhiza Ularensis Roots, Acts in the Lower Part of Intestine

Autor: Hidemasa Nagai, Teruaki Akao, Tadato Tani, Ju-Xiu He, Yuji Sato

Publikováno v: Biological and Pharmaceutical Bulletin. 30:145-149

Glycyrrhizae radix is used to treat abdominal pain as a component of shakuyakukanzoto (shaoyao-gancao-tang), a traditional Chinese medicine formulation. Previously, we have reported the isolation of glycycoumarin as a potent antispasmodic with an IC5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d978b4f85570226231f70b2bda405b0
https://doi.org/10.1248/bpb.30.145

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Metabolism of dextran sulfate sodium by intestinal bacteria in rat cecum is related to induction of colitis

Autor: Masakiyo Sasahara, Satoshi Shiotsuki, Teruaki Akao, Yugi Oyanagi, Yoko Ishii

Publikováno v: Biologicalpharmaceutical bulletin. 38(4)

Ulcerative colitis induced by dextran sulfate sodium (DSS) is one of the most widely used experimental animal models. However, the mechanism responsible for the pathogenesis of the colitis is still unclear. The aim of the present study was to clarify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028aa398e4edc257c3a590a62e30c325
https://pubmed.ncbi.nlm.nih.gov/25832637

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Pharmacokinetic study of benzoylmesaconine in rats using an enzyme immunoassay system

Autor: Teruaki Akao, Jing Zhao, Feng Zuo, Masao Hattori, Norio Nakamura, Jiang-Jing Gao, Yuichi Kikuchi, Yuji Oomiga

Publikováno v: Journal of Natural Medicines. 60:313-321

A highly sensitive enzyme immunoassay (EIA) system for quantitative determination of benzoylmesaconine (BM) in biological samples was developed. The sensitivity of an antiserum towards β-galactosidase (β-gal)-labeled antigen was in the range of 10�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::994d09dc542947805a1c1bf9c8530115
https://doi.org/10.1007/s11418-006-0011-0

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Pharmaceutical Evaluation of Cultivated Glycyrrhiza uralensis Roots in Comparison of Their Antispasmodic Activity and Glycycoumarin Contents with Those of Licorice

Autor: Hidemasa Nagai, Teruaki Akao, Tadato Tani, Yuji Sato, Yutaka Yamamoto

Publikováno v: Biological and Pharmaceutical Bulletin. 29:2442-2445

In China, the collection of wild Glycyrrhiza uralensis, one of the raw materials of Chinese licorice, has been restricted to prevent desertification. To compensate for the reduced supply of wild Glycyrrhiza plants, cultivation programs of G. uralensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7727e9906b02ee61c198fbb9f51b5ff
https://doi.org/10.1248/bpb.29.2442

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Enteric Excretion of Baicalein, a Flavone of Scutellariae Radix, via Glucuronidation in Rat: Involvement of Multidrug Resistance-Associated Protein 2

Autor: Katsutoshi Terasawa, Yoko Sakashita, Hirozo Goto, Yutaka Shimada, Masato Hanada, Teruaki Akao

Publikováno v: Pharmaceutical Research. 21:2120-2126

Baicalin (BG) and its aglycone, baicalein (B), are strong antioxidants and have various pharmacological actions. The purpose of this study was to evaluate efflux of BG from rat intestinal mucosal cell following glucuronidation of B absorbed after ora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddd5c4a78c0bfecd22d190eb22dccc6
https://doi.org/10.1023/b:pham.0000048205.02478.b5

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Estrogenic and Antiestrogenic Activities of the Roots of Moghania philippinensis and Their Constituents

Autor: Eun-Mi Ahn, Tsutomu Nishihara, Norio Nakamura, Masao Hattori, Teruaki Akao

Publikováno v: Biological and Pharmaceutical Bulletin. 27:548-553

In the course of our search for natural estrogenic compounds from medicinal plants, we found that the methanolic extract from the roots of Moghania philippinensis (Fabaceae) showed significant effects on the proliferation of MCF-7 cells (human breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fce4f77617d2366c845d16ef75c5b58
https://doi.org/10.1248/bpb.27.548

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Simultaneous Determination of Isoline and Its Two Major Metabolites Using High-Performance Liquid Chromatography

Autor: Zheng-Tao Wang, Norio Nakamura, Jun Tang, Masao Hattori, Mian Zhang, Teruaki Akao

Publikováno v: Journal of Analytical Toxicology. 28:11-15

A simple and reliable high-performance liquid chromatographic (HPLC) assay was developed for a simultaneous determination of isoline, a potent hepatotoxic pyrrolizidine alkaloid, and its two major metabolites, namely M1 (bisline) and M2 (bisline lact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13265f58e0db1631e510cea7f4c6250c
https://doi.org/10.1093/jat/28.1.11

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