Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Tertiary lymphoid structure (TLS)"'
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-15 (2024)
Abstract Soft tissue sarcomas (STS) have long been a formidable challenge in oncology, partly because of their rarity and diversity, which complicates large-scale studies and slows the advent of new treatments. Traditionally anchored by anthracycline
Externí odkaz:
https://doaj.org/article/7ef21262418c46b9b7f1ab1e7ac20ce2
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 9, Pp n/a-n/a (2024)
Abstract Objectives This study systematically evaluated the relationship between tertiary lymphoid structures (TLS) and clinical pathological features as well as immune infiltrating cells in gastrointestinal cancers. Methods We searched Web of scienc
Externí odkaz:
https://doaj.org/article/93487915ed754f90b5b72da45c3ed046
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Stem-like CD8+ T cells (TSL) are a subset of immune cells with superior persistence and antitumor immunity. They are TCF1+ PD-1+ and important for the expansion of tumor specific CD8+ T cells in response to checkpoint blockade immunotherapy. In acute
Externí odkaz:
https://doaj.org/article/13a08e510f1d491ebf53670f781b5c22
Autor:
Hui Sun, Yuxi Liu, Wanjing Cheng, Rong Xiong, Wenchao Gu, Xiaoyan Zhang, Xin Wang, Xu Wang, Cong Tan, Weiwei Weng, Meng Zhang, Shujuan Ni, Dan Huang, Midie Xu, Weiqi Sheng, Lei Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionTertiary lymphoid structures (TLSs) are analogues of secondary lymphoid organs that contain various immune cells. The spatial distribution, maturation and composition of TLSs have differential effects on prognosis, and the roles of TLSs i
Externí odkaz:
https://doaj.org/article/673678c6e2054e18862756b147249f84
Autor:
Zhao Zhan, Liu Shi-jin, Zhang Yi-ran, Liu Zhi-long, Zhao Xiao-xu, Ding Hui, Yun-long Pan, Jing-hua Pan
Publikováno v:
Annals of Medicine, Vol 55, Iss 1, Pp 114-126 (2023)
AbstractBackground High endothelial venules (HEV) and tertiary lymphoid structures (TLS) are associated with clinical outcomes of patients with colorectal cancer (CRC). However, because HEV are components of TLS, there have been few studies of the ro
Externí odkaz:
https://doaj.org/article/b58c36d87a0149429a98230588c182a6
Autor:
Rui Zhao, Jiacheng Li, Bo Chen, Jungang Zhao, Leyin Hu, Kate Huang, Qiwen Chen, Jiangqiao Yao, Ganglian Lin, Lishimeng Bao, Mengmeng Lu, Yi Wang, Gang Chen, Fang Wu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Backgrounds and aimsImmunotherapies have formed an entirely new treatment paradigm for hepatocellular carcinoma (HCC). Tertiary lymphoid structure (TLS) has been associated with good response to immunotherapy in most solid tumors. Nonetheless, the ro
Externí odkaz:
https://doaj.org/article/6efe1d583708410398160feafdc6a64e
Autor:
Qian Wang, Yuan Zhi, Moxin Zi, Yongzhen Mo, Yumin Wang, Qianjin Liao, Shanshan Zhang, Zhaojian Gong, Fuyan Wang, Zhaoyang Zeng, Can Guo, Wei Xiong
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor occurrence and development for its ability to study gene expression at the individual cell level. However, patient‐derived tumor tissues are composed
Externí odkaz:
https://doaj.org/article/7681edcb67fc484b9f457b8ea48c6ded
Autor:
Aoyang Yu, Menghan Cao, Kaile Zhang, Yule Yang, Luyao Ma, Xinran Zhang, Yang Zhao, Xiao Ma, Zhixiang Fan, Zhengxiang Han, Hongmei Wang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundNumerous studies and research papers have provided evidence suggesting that tertiary lymphoid structures (TLS) play a crucial role in combating and suppressing tumor growth and progression. Despite the wealth of information on the significa
Externí odkaz:
https://doaj.org/article/f5b24ef7ad1448d7a758faefa074e67f
Autor:
Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIncreased T cell infiltration and interferon gamma (IFNγ) pathway activation are seen in tumors of melanoma patients who respond to ICI (immune checkpoint inhibitor) or MAPK pathway inhibitor (MAPKi) therapies. Yet, the rate of durable t
Externí odkaz:
https://doaj.org/article/90773f18c9604dea88e9ab2eb0be4fa5
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have been widely used in constructing spatial tissue atlases and characterizing spatiotemporal heterogeneity of cancers. Currently, ST has been used to profile spat
Externí odkaz:
https://doaj.org/article/16fa3e085df84ef5bf114ef8b6fa9876