Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Tertia D. Purves-Tyson"'
Autor:
Tertia D. Purves-Tyson, Amelia M. Brown, Christin Weissleder, Debora A. Rothmond, Cynthia Shannon Weickert
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotransmission may contribute to the
Externí odkaz:
https://doaj.org/article/fc6b3499f9d048d3b8fbc72a998340f8
Autor:
Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A. Newell
Publikováno v:
Journal of Psychiatric Research. 160:204-209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64334af28e8fb805ef16483ae976ede2
https://doi.org/10.1016/j.jpsychires.2023.02.017
https://doi.org/10.1016/j.jpsychires.2023.02.017
Autor:
Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of schizophrenia cases can be defined as having a “high inflammatory/immu
Externí odkaz:
https://doaj.org/article/469da861d99b486b90ec11e5fa7102fc
Autor:
Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A. Newell
Publikováno v:
Journal of psychiatric research. 147
Evidence, largely obtained from peripheral studies, suggests that alterations in the kynurenine pathway contribute to the aetiology of depression and disorders involving psychosis. Stimulation of the kynurenine pathway leads to the formation of neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568cb10f163f0912ed095a358c776190
https://pubmed.ncbi.nlm.nih.gov/35063739
https://pubmed.ncbi.nlm.nih.gov/35063739
Autor:
Christin Weissleder, Cynthia Shannon Weickert, Debora A. Rothmond, Amelia M. Brown, Tertia D. Purves-Tyson
Publikováno v:
Molecular Brain
Molecular Brain, Vol 14, Iss 1, Pp 1-19 (2021)
Molecular Brain, Vol 14, Iss 1, Pp 1-19 (2021)
Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotransmission may contribute to the hyperdop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284fd0ac0118329d57fff9cf3e24e643
https://doi.org/10.1186/s13041-021-00805-7
https://doi.org/10.1186/s13041-021-00805-7
Autor:
Tertia D Purves-Tyson, Samantha J Owens, Kay L Double, Reena Desai, David J Handelsman, Cynthia Shannon Weickert
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91151 (2014)
Adolescent males have an increased risk of developing schizophrenia, implicating testosterone in the precipitation of dopamine-related psychopathology. Evidence from adult rodent brain indicates that testosterone can modulate nigrostriatal dopamine.
Externí odkaz:
https://doaj.org/article/0aedeec00a99490f8a0a7b6f39096e3a
Autor:
David J. Handelsman, Ellen Ji, Cynthia Shannon Weickert, Maryanne O'Donnell, Reena Desai, Cherrie Galletly, Thomas W. Weickert, Tertia D. Purves-Tyson, Rhoshel K. Lenroot, Dennis Liu, Christopher J. White
While high levels of glucocorticoids are generally neuro-damaging, a related adrenal steroid, dehydroepiandrosterone (DHEA), has anti-glucocorticoid and neuroprotective properties. Previous work has shown increased circulating levels of DHEA and abno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d10f210ea3be3022f6bdbc202a60a43
https://doi.org/10.5167/uzh-205621
https://doi.org/10.5167/uzh-205621
Autor:
Amelia M. Brown, Illya Conn, Danny Boerrigter, Cynthia Shannon Weickert, Tertia D. Purves-Tyson
Publikováno v:
Journal of Neuroimmunology. 364:577813
Maternal immune activation (MIA) with poly(I:C) is a preclinical paradigm for schizophrenia and autism research. Methodological variations, including poly(I:C) molecular weight, contribute to inconsistencies in behavioural and molecular outcomes. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba50b93797be6135b153a11a73eb859
https://doi.org/10.1016/j.jneuroim.2022.577813
https://doi.org/10.1016/j.jneuroim.2022.577813
Autor:
Debora A. Rothmond, Danny Boerrigter, Tertia D. Purves-Tyson, Helen Q Cai, Cynthia Shannon Weickert
Publikováno v:
Schizophrenia Bulletin
Background Neuroinflammation and dopamine dysregulation contribute to psychosis and cognitive deficits in schizophrenia. Approximately 50% of people with schizophrenia have elevated gene expression of proinflammatory cytokines in the postmortem midbr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd8533405147fbc9d9ece39c934a091
http://europepmc.org/articles/PMC7234088
http://europepmc.org/articles/PMC7234088
Publikováno v:
Psychiatry research. 280
Anxiety and depressive disorders are more prevalent in hypogonadal men. Low testosterone levels are associated with greater negative symptoms and impaired cognition in men with schizophrenia. Thus, androgens may contribute to brain pathophysiology in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfac7f0d727ada2497cb7fcfc186c30c
https://pubmed.ncbi.nlm.nih.gov/31446215
https://pubmed.ncbi.nlm.nih.gov/31446215