Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue.

Autor: Modder M; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Coomans CP; Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Saaltink DJ; Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Tersteeg MMH; Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Hoogduin J; Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Scholten L; Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Pronk ACM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Lalai RA; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Boelen A; Endocrine Laboratory, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands., Kalsbeek A; Endocrine Laboratory, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Endocrinology and Metabolism, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.; Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands., Rensen PCN; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Vreugdenhil E; Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands., Kooijman S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. s.kooijman@lumc.nl.; Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands. s.kooijman@lumc.nl.

Publikováno v: Scientific reports [Sci Rep] 2024 Aug 22; Vol. 14 (1), pp. 19517. Date of Electronic Publication: 2024 Aug 22.

Small-molecule CEM3 strengthens single-cell oscillators in the suprachiasmatic nucleus.

Autor: van Beurden AW; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Tersteeg MMH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Michel S; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., van Veldhoven JPD; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Rohling JHT; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Meijer JH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Jan; Vol. 38 (1), pp. e23348.

Induction of Fatigue by Specific Anthracycline Cancer Drugs through Disruption of the Circadian Pacemaker.

Autor: Wang Y; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Zanden SYV; Department of Cell and Chemical Biology, ONCODE Institute, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., van Leerdam S; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Tersteeg MMH; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Kastelein A; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Michel S; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Neefjes J; Department of Cell and Chemical Biology, ONCODE Institute, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Meijer JH; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Deboer T; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.

Publikováno v: Cancers [Cancers (Basel)] 2022 May 13; Vol. 14 (10). Date of Electronic Publication: 2022 May 13.