Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain

Autor: van Eijk, Martin, Hillaire, Marine L. B., Rimmelzwaan, Guus F., Rynkiewicz, Michael J., White, Mitchell R., Hartshorn, Kevan L., Hessing, Martin, Koolmees, Peter A., Tersteeg, Monique H., van Es, Maarten H., Meijerhof, Tjarko, Huckriede, Anke, Haagsman, Henk P., LS Moleculaire Afweer, Dep Infectieziekten Immunologie, One Health Microbieel, dIRAS RA-I&I I&I, dIRAS RA-I&I RA, dI&I I&I-3

Publikováno v: Frontiers in Immunology, 10. Frontiers Media S.A.
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, 10:2476. Frontiers Media SA
Frontiers in Immunology, 10:2476. Frontiers Media S.A.

Innate immunity is critical in the early containment of influenza A virus (IAV) infection and surfactant protein D (SP-D) plays a crucial role in innate defense against IAV in the lungs. Multivalent lectin-mediated interactions of SP-D with IAVs resu

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https://dspace.library.uu.nl/handle/1874/389367

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Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain.

Autor: van Eijk M; Division of Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands., Hillaire MLB; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands., Rimmelzwaan GF; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hanover, Germany., Rynkiewicz MJ; Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA, United States., White MR; Department of Medicine, Boston University School of Medicine, Boston, MA, United States., Hartshorn KL; Department of Medicine, Boston University School of Medicine, Boston, MA, United States., Hessing M; U-Protein Express B.V., Life Science Incubator, Utrecht, Netherlands., Koolmees PA; Division of Veterinary Public Health, Faculty of Veterinary Medicine, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands., Tersteeg MH; Division of Veterinary Public Health, Faculty of Veterinary Medicine, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands., van Es MH; NOMI, Optomechatronics, TNO, Delft, Netherlands., Meijerhof T; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Huckriede A; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Haagsman HP; Division of Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Oct 22; Vol. 10, pp. 2476. Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019).