Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Terry Watnick"'
Publikováno v:
BMC Nephrology, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background The Covid-19 pandemic greatly affected those with chronic diseases, impacting healthcare access and healthcare seeking behaviors. The impact of the pandemic on adults with Autosomal Dominant Polycystic Kidney Disease (ADPKD) has n
Externí odkaz:
https://doaj.org/article/7ba186ec5b2145e5914db192b56ee827
Autor:
Rebecca V Walker, Qin Yao, Hangxue Xu, Anthony Maranto, Kristen F Swaney, Sreekumar Ramachandran, Rong Li, Laura Cassina, Brian M Polster, Patricia Outeda, Alessandra Boletta, Terry Watnick, Feng Qian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Fibrocystin/Polyductin (FPC), encoded by PKHD1, is associated with autosomal recessive polycystic kidney disease (ARPKD), yet its precise role in cystogenesis remains unclear. Here we show that FPC undergoes complex proteolytic processing in
Externí odkaz:
https://doaj.org/article/51cef6557ba141899a2c0bf5768dce69
Autor:
Gregory Mader, Deirdre Mladsi, Myrlene Sanon, Molly Purser, Christine L. Barnett, Dorothee Oberdhan, Terry Watnick, Stephen Seliger
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Tolvaptan was approved in the United States in 2018 for patients with autosomal dominant polycystic kidney disease (ADPKD) at risk of rapid progression as assessed in a 3-year phase 3 clinical trial (TEMPO 3:4). An extension study
Externí odkaz:
https://doaj.org/article/5012d7449565465983d9a5ca5e2e3696
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) often develop hypertension in childhood or early adulthood. Although this could result in left ventricular hypertrophy (LVH), a major risk factor for cardiovascula
Externí odkaz:
https://doaj.org/article/ef22203ea5324726a95d23eb179ddd95
Autor:
Mats C. H. Lassen, Atif N. Qasim, Tor Biering-Sørensen, Jacob L. T. Reeh, Terry Watnick, Stephen L. Seliger, Huanwen Chen, Mariem A. Sawan, Daniel Nguyen, Yongfang Li, Susie N. Hong, Meyeon Park
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of cardiovascular morbidity and mortality. Impaired left ventricular (LV) global longitudinal strain (GLS) can be a sign of subclinical card
Externí odkaz:
https://doaj.org/article/2ba5499ccd0c43baa351d8835f7d4633
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009217 (2020)
A unifying feature of polycystin-2 channels is their localization to both primary and motile cilia/flagella. In Drosophila melanogaster, the fly polycystin-2 homologue, Amo, is an ER protein early in sperm development but the protein must ultimately
Externí odkaz:
https://doaj.org/article/3de5abd451c94ce59dfb87e8c77f0287
Autor:
Jun-ya Kaimori, Cheng-Chao Lin, Patricia Outeda, Miguel A. Garcia-Gonzalez, Luis F. Menezes, Erum A. Hartung, Ao Li, Guanqing Wu, Hideaki Fujita, Yasunori Sato, Yasuni Nakanuma, Satoko Yamamoto, Naotsugu Ichimaru, Shiro Takahara, Yoshitaka Isaka, Terry Watnick, Luiz F. Onuchic, Lisa M. Guay-Woodford, Gregory G. Germino
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Autosomal recessive polycystic kidney disease (ARPKD) is an important childhood nephropathy, occurring 1 in 20,000 live births. The major clinical phenotypes are expressed in the kidney with dilatation of the collecting ducts, systemic hyper
Externí odkaz:
https://doaj.org/article/89f3879b5d154e2796418eb76debe918
Autor:
Alexis Hofherr, Claudia Seger, Fiona Fitzpatrick, Tilman Busch, Elisabeth Michel, Jingting Luan, Lea Osterried, Frieder Linden, Albrecht Kramer-Zucker, Barbara Wakimoto, Conny Schütze, Nils Wiedemann, Anna Artati, Jerzy Adamski, Gerd Walz, Edmund R S Kunji, Craig Montell, Terry Watnick, Michael Köttgen
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2005651 (2018)
Cilia are organelles specialized in movement and signal transduction. The ciliary transient receptor potential ion channel polycystin-2 (TRPP2) controls elementary cilia-mediated physiological functions ranging from male fertility and kidney developm
Externí odkaz:
https://doaj.org/article/fb76b96ee34346ac93852c1d9cd88af5
Autor:
Patricia Outeda, David L. Huso, Steven A. Fisher, Marc K. Halushka, Hyunho Kim, Feng Qian, Gregory G. Germino, Terry Watnick
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 634-644 (2014)
Autosomal dominant polycystic kidney disease is a common form of inherited kidney disease that is caused by mutations in two genes, PKD1 (polycystin-1) and PKD2 (polycystin-2). Mice with germline deletion of either gene die in midgestation with a vas
Externí odkaz:
https://doaj.org/article/aa93f166cf0d4e14aabba3dd8b88d730
Autor:
Xudong Wu, Artur A Indzhykulian, Paul D Niksch, Roxanna M Webber, Miguel Garcia-Gonzalez, Terry Watnick, Jing Zhou, Melissa A Vollrath, David P Corey
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155577 (2016)
Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled out based on lack of an inne
Externí odkaz:
https://doaj.org/article/b00f9182aaf54875992b113d3ab2035d