Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Terry W. Moore"'
Autor:
May Barakat, Chen Han, Lin Chen, Brian P. David, Junhe Shi, Angela Xu, Kornelia J. Skowron, Tatum Johnson, Reginald A. Woods, Aparna Ankireddy, Sekhar P. Reddy, Terry W. Moore, Luisa A. DiPietro
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-24 (2024)
Abstract The transcription factor NRF2 plays an important role in many biological processes and is a promising therapeutic target for many disease states. NRF2 is highly expressed in the skin and is known to play a critical role in diabetic wound hea
Externí odkaz:
https://doaj.org/article/2bc85f20295a4c28a88558c8a966f094
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1885-1892 (2023)
A principal challenge in computational modeling of macromolecules is the vast conformational space that arises out of large numbers of atomic degrees of freedom. Recently, growing interest in building predictive models of complexes mediated by Proteo
Externí odkaz:
https://doaj.org/article/bb5e9e9082254c22b23aa4662afe951f
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101265- (2022)
Summary: Pharmacologic inhibition of the protein-protein interaction (PPI) interface of the Keap1:Nrf2 complex, which leads to Nrf2 activation and cytoprotective gene expression, offers a promising strategy for disease prevention and treatment. To fa
Externí odkaz:
https://doaj.org/article/766063801b5e49d2a33f13f6b82b19ae
Autor:
Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova-Kostova, Takuma Kasai, Takashi Kamei, Seizo Koshiba, Masayuki Yamamoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Using NMR spectroscopy, Horie, Suzuki, Inoue et al. show that the dissociation of Keap1 from Nrf2, or the Hinge-Latch mechanism, is triggered by Keap1-Nrf2 inhibitors and occurs during p62- mediated Nrf2 activation, but not by electrophilic Nrf2 indu
Externí odkaz:
https://doaj.org/article/b744783a8c5b4f278122faa72d2167f4
Autor:
Sharadha Dayalan Naidu, Takafumi Suzuki, Dina Dikovskaya, Elena V. Knatko, Maureen Higgins, Miu Sato, Miroslav Novak, José A. Villegas, Terry W. Moore, Masayuki Yamamoto, Albena T. Dinkova-Kostova
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103703- (2022)
Summary: Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development. Here, we show t
Externí odkaz:
https://doaj.org/article/fbb65bab03f04fcc88cc16d6d8bb2c93
Autor:
Katherine E. Zink, Denise A. Ludvik, Phillip R. Lazzara, Terry W. Moore, Mark J. Mandel, Laura M. Sanchez
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
The complexity of animal microbiomes presents challenges to defining signaling molecules within the microbial consortium and between the microbes and the host. By focusing on the binary symbiosis between Vibrio fischeriEuprymna scolopes
Externí odkaz:
https://doaj.org/article/38dee9e7531241269427c923c2d269cd
Autor:
Terry W. Moore, Kasinath Sana, Dan Yan, Pahk Thepchatri, John M. Ndungu, Manohar T. Saindane, Mark A. Lockwood, Michael G. Natchus, Dennis C. Liotta, Richard K. Plemper, James P. Snyder, Aiming Sun
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 197-203 (2013)
High-throughput screening (HTS) previously identified benzimidazole 1 (JMN3-003) as a compound with broad antiviral activity against different influenza viruses and paramyxovirus strains. In pursuit of a lead compound from this series for development
Externí odkaz:
https://doaj.org/article/6b0f1e5db9f2406e82334141924a14ef
Autor:
Saad Alqarni, Laura Cooper, Jazmin Galvan Achi, Ryan Bott, Veeresh Kumar Sali, Andrew Brown, Bernard D. Santarsiero, Aleksej Krunic, Balaji Manicassamy, Norton P. Peet, Pin Zhang, Gregory R. J. Thatcher, Irina N. Gaisina, Lijun Rong, Terry W. Moore
Publikováno v:
Journal of Medicinal Chemistry. 65:14104-14120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2419fd8cb167e8defe6024cc591faf50
https://doi.org/10.1021/acs.jmedchem.2c01329
https://doi.org/10.1021/acs.jmedchem.2c01329
Autor:
Ryan A. Altman, Annalaura Brai, Jennifer Golden, Giuseppe La Regina, Zhengqiu Li, Terry W. Moore, William C. K. Pomerantz, Naomi S. Rajapaksa, Ashley M. Adams
Publikováno v:
ACS Med Chem Lett
[Image: see text] Innovation in medicinal chemistry has been at the heart of ACS Medicinal Chemistry Letters since the journal’s founding 10 years ago. In his inaugural editorial, Editor-in-Chief Dennis Liotta laid out a vision for the journal to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6526cb39b8627a49e6f7306f942874cc
https://doi.org/10.1021/acsmedchemlett.1c00623
https://doi.org/10.1021/acsmedchemlett.1c00623
Autor:
Alexander S. Mankin, Amira Kefi, Sarah Colon, Teresa Szal, Tyler J Brown, Terry W. Moore, Vallari Shah, Nora Vazquez-Laslop, Chetana Baliga, Kornelia J. Skowron, Dorota Klepacki, Tanja Florin
Publikováno v:
Proc Natl Acad Sci U S A
Apidaecin (Api), an unmodified 18-amino-acid-long proline-rich antibacterial peptide produced by bees, has been recently described as a specific inhibitor of translation termination. It invades the nascent peptide exit tunnel of the postrelease ribos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a29bde975acc2abaee0e565a6e27223
