Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Terry V. Hughes"'
Autor:
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Publikováno v:
eLife, Vol 7 (2018)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06
Autor:
David H. Drewry, Steve Hitchcock, Volker Dötsch, Ingo Hartung, Brian D. Marsden, Hisanori Matsui, C. Bountra, Carrow I. Wells, Marcus Bauser, Stefan Knapp, Volkhart Mj Li, Amélia Yi Viana, Christian Fischer, Mathias John Paul, Adrian Carter, Spiros Liras, Julian Blagg, Mark Edward Bunnage, Suzanne Ackloo, Adriaan P. IJzerman, Susanne Müller, Stephen V. Frye, Saul H Rosenberg, Natalie S Schneider, Daniel K Treiber, Andreas Gollner, David R. Damerell, Cora Scholten, Bryan L. Roth, Cheryl H. Arrowsmith, Charles E. Grimshaw, Aled M. Edwards, Kumar Singh Saikatendu, Timothy M. Willson, Jeremy L Baryza, Thomas Hanke, Masayuki Takizawa, Peter Brown, Terry V Hughes, James P. Edwards, Daniel Rauh, Trevor Howe, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Chris Tse, Vineet Pande, Anton Simeonov, Paul R. Thompson, Dafydd R. Owen, J.M. Elkins, Jark Böttcher, William J. Zuercher, Stefan Laufer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d718f899c5ce6099584927eb7f1b37e
https://doi.org/10.7554/elife.34311.009
https://doi.org/10.7554/elife.34311.009
Autor:
Julian Blagg, David H. Drewry, Steve Hitchcock, Hisanori Matsui, Carrow I. Wells, Daniel Rauh, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Adriaan P. IJzerman, Kumar Singh Saikatendu, Stefan Laufer, Timothy M. Willson, Paul R. Thompson, Chris Tse, Saul H Rosenberg, C. Bountra, Marcus Bauser, Dafydd R. Owen, Brian D. Marsden, Terry V Hughes, Daniel K Treiber, James P. Edwards, Bryan L. Roth, Cheryl H. Arrowsmith, Suzanne Ackloo, J.M. Elkins, Adrian Carter, Spiros Liras, Stefan Knapp, Christian Fischer, Susanne Müller, Amélia Yi Viana, Mathias John Paul, William J. Zuercher, Masayuki Takizawa, Jeremy L Baryza, Thomas Hanke, Peter Brown, David R. Damerell, Cora Scholten, Stephen V. Frye, Anton Simeonov, Mark Edward Bunnage, Charles E. Grimshaw, Andreas Gollner, Aled M. Edwards, Natalie S Schneider, Trevor Howe, Volker Dötsch, Ingo Hartung, Jark Böttcher, Vineet Pande, Volkhart Mj Li
Publikováno v:
eLife, Vol 7 (2018)
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba91100a44a3d9b67ccf3f2841cb55bf
Autor:
Stuart Emanuel, Lee M. Greenberger, Guozhang Xu, Sandra Moreno-Mazza, Niranjan Pandey, Steven A. Middleton, Peter J. Connolly, Prabha Karnachi, Steven K. Wetter, Terry V. Hughes, Mary Adams, Scott R. Pollack
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4896-4899
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine was synthesized and found to have potent dual EGFR/HER2 kinase inhibitory activity. The structure-based drug design of this molecule as well as the kinase and cellular inhibition of HER2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fc06459e8de9b189b2ea8e7ec097ab
https://doi.org/10.1016/j.bmcl.2008.07.057
https://doi.org/10.1016/j.bmcl.2008.07.057
Autor:
Catherine A. Rugg, Angel R. Fuentes-Pesquera, Steven A. Middleton, Stuart Emanuel, Peter J. Connolly, Richard S. Alexander, Terry V. Hughes, Prabha Karnachi, Harold R. O’Grady
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5130-5133
A novel series of 7-[1H-indol-2-yl]-2,3-dihydro-isoindol-1-ones designed to be inhibitors of VEGF-R2 kinase was synthesized and found to potently inhibit VEGF-R2 and Aurora-A kinases. The structure-based design, synthesis, and initial SAR of the seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74affa60ae9f6997d3605a0b25abe5da
https://doi.org/10.1016/j.bmcl.2008.07.090
https://doi.org/10.1016/j.bmcl.2008.07.090
Autor:
Sandra Moreno-Mazza, Stuart Emanuel, Peter J. Connolly, Niranjan Pandey, Robert H. Gruninger, Lee M. Greenberger, Virna Borowski, Steven A. Middleton, Terry V. Hughes, Jennifer R. Story, Cheryl Napier, Jeannene Butler, Mary Adams, Beth A. Hollister, Catherine A. Rugg, Angel R. Fuentes‐Pesquera
Publikováno v:
Molecular Pharmacology. 73:338-348
JNJ-28871063 is a potent and highly selective pan-ErbB kinase inhibitor from a novel aminopyrimidine oxime structural class that blocks the proliferation of epidermal growth factor receptor (EGFR; ErbB1)- and ErbB2-overexpressing cells but does not a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013ff7bc8f34e49c45e49e5e90b6d746
https://doi.org/10.1124/mol.107.041236
https://doi.org/10.1124/mol.107.041236
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5845-5856
The preparation of a novel series of N-aryl CBI derivatives in which an aryl substituent could be used to predictably modulate the reactivity of the resulting CC-1065/duocarmycin alkylation subunit analogue is detailed and its extension to a unique s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eaf0a428298c479540dbc4429071ab1
https://doi.org/10.1016/j.bmc.2004.08.032
https://doi.org/10.1016/j.bmc.2004.08.032
Publikováno v:
The Journal of Organic Chemistry. 66:2207-2216
The synthesis of 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (C5-CO2Me-CBI), a substituted CBI derivative bearing a C5 methoxycarbonyl group, and its corresponding 5-hydroxymethyl derivative are described in efforts to establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f576d05a59eb9730e95384360fec090
https://doi.org/10.1021/jo001772g
https://doi.org/10.1021/jo001772g
Autor:
Michael P. Cava, M. V. Lakshmikantham, Bo Chen, Brenda Mokijewski, Robert M. Metzger, Terry V. Hughes
Publikováno v:
Langmuir. 15:6925-6930
Five zwitterions based on a coupling reaction between 2-methylbenzothiazole and its selenium and tellurium analogues with the lithium salt of tetracyanoquinodimethane were designed and synthesized, bearing long alkyl tails to facilitate Pockels−Lan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f70d35d54411ab8dd4725004ba796a9
https://doi.org/10.1021/la9817260
https://doi.org/10.1021/la9817260
Autor:
Valery V. Konovalov, Bo Chen, Lowell D. Kispert, Robert M. Metzger, Shane C. Street, Hiromi Sakurai, Terry V. Hughes, Michael P. Cava, Camino S. Simpson, Jeffrey W. Baldwin, M. V. Lakshmikantham
Publikováno v:
The Journal of Physical Chemistry B. 103:4269-4277
Hexadecylquinolinium tricyanoquinodimethanide (1), a unimolecular rectifier of electrical current with a large ground-state dipole moment (43 ± 8 D), reveals large hypsochromic shifts of the absorption spectrum. Two fluorescent emissions were observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa68763fbd6d3fe2ab6e0b73aeceac88
https://doi.org/10.1021/jp983759u
https://doi.org/10.1021/jp983759u