Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Terry T. Conway"'
Autor:
Frances N. Shirota, Herbert T. Nagasawa, Eugene G. DeMaster, David J.W. Goon, Terry T. Conway
Publikováno v:
Journal of Medicinal Chemistry. 42:4016-4020
Benzenesulfohydroxamic acid (Piloty's acid) was functionalized on the hydroxyl group with the N,N-diethylcarbamoyl group, and the hydroxylamine nitrogen was substituted with acetyl (1a), pivaloyl (1b), benzoyl (1c), and ethoxycarbonyl (1d) groups. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c35a84b3aef4bd77e6b90a4b766981
https://doi.org/10.1021/jm990235p
https://doi.org/10.1021/jm990235p
Publikováno v:
Journal of Medicinal Chemistry. 41:2903-2909
The prototypic aromatic C-nitroso compound, nitrosobenzene (NB), was shown previously to mimic the effect of nitroxyl (HN=O), the putative active metabolite of cyanamide, in inhibiting aldehyde dehydrogenase (AlDH). To minimize the toxicity of NB in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2d2ffaed700283a703ff340fc95c7b1
https://doi.org/10.1021/jm980200+
https://doi.org/10.1021/jm980200+
Autor:
Bing Yu Luh, Michael Casey, Bernard Belleau, Lee Morris, Daniel Tim-Wu Chu, Terry T. Conway, Gary Lim, Terrence W. Doyle, Marcel Menard, Pierre Rivest, James L. Douglas
Publikováno v:
Canadian Journal of Chemistry. 55:484-507
The preparation by total synthesis of a new class of β-lactam antibiotics is reported. Conversion of alcohol 1b to its mesylate 9b followed by hydrolysis of the acetal to the enol 1b and base-catalyzed ring closure gave benzyl 7- β-azido-Δ3-O-2-is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ec85269bc235e745ce01b53e57f689
https://doi.org/10.1139/v77-070
https://doi.org/10.1139/v77-070
Publikováno v:
Canadian Journal of Chemistry. 57:227-232
Treatment of the acid 3 with triethylamine in refluxing tert-butyl alcohol gave the decarboxylated product 4 which was isomerized to the desired Δ3 isomer 5 using DBN. Reduction of the azido functions in 4 and 5 followed by coupling to phenoxyacetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::248122587c396e995c17046c6b454206
https://doi.org/10.1139/v79-037
https://doi.org/10.1139/v79-037
Nuclear analogs of β -lactam antibiotics. IX. Synthesis of 7-methoxy 2-isocephems and O-2 isocephems
Publikováno v:
Canadian Journal of Chemistry. 56:2879-2883
The syntheses of 7-methoxy-7-phenoxyacetamido-3-methyl-Δ3-isocephem-4-carboxylic acid 11a, 7-methoxy-7-phenoxyacetamido-3-rnethyl- Δ3-O-2-isocephem-4-carboxylic acid 11b and 7-methoxy-7-(2-thienyl)acetamido-3-acetoxymethyl- Δ3-O-2-isocephem-4-carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e0760e3c05e9f6cc07b5de474007a42
https://doi.org/10.1139/v78-473
https://doi.org/10.1139/v78-473
Publikováno v:
Canadian Journal of Chemistry. 53:237-244
The synthesis of 1-aminoalkyl-1-hydroxy-2,2-tetramethylene-1,2,3,4-tetrahydronaphthalenes and their Wagner–Meerwein rearrangements into 4a-aminoalkyl-1,2,3,4,4a,9-hexahydrophen-anthrenes are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6557e6f8bdc8788aef2a94cdfe95b14e
https://doi.org/10.1139/v75-033
https://doi.org/10.1139/v75-033
Publikováno v:
Canadian Journal of Chemistry. 57:222-226
The syntheses of the desthiocephem system from the enol 2 is described. Thus conversion of 2 to its triflate 3 followed by treatment with the sodium salts of malonate esters gave the cyclized products 4a–c. Azide reduction followed by coupling of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6a813522afaf963f30589c98d70f61
https://doi.org/10.1139/v79-036
https://doi.org/10.1139/v79-036
Publikováno v:
Canadian Journal of Chemistry. 53:245-255
The syntheses of members of the D-normorphinan system, which is unreported prior to this work, are described. Two methods employing 4a-aminomethyl-1,2,3,4,4a,9-hexahydrophenan-threnes (1a-d) as starting materials were developed. These were the base-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba7cbe4f5a9b2b35edf07c53f10a3b8a
https://doi.org/10.1139/v75-034
https://doi.org/10.1139/v75-034
Autor:
Gary Lim, James L. Douglas, Martin Misiek, Marcel Menard, Leeson R. Morris, Bing Yu Luh, C. F. Ferrari, Alain Martel, Donald E. Horning, Terry T. Conway, Terrence W. Doyle, Bernard Belleau
Publikováno v:
Canadian Journal of Chemistry. 58:2508-2523
The general synthetic scheme to nuclear analogs of cephalosporins described in previous papers of this series is reviewed and the synthesis of a series of sidechain derivatives is given. Thus, systems of the following type were formed: carbacephems (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de43929eb0977d9da3ae48ba657b07ef
https://doi.org/10.1139/v80-402
https://doi.org/10.1139/v80-402
Autor:
Leeson R. Morris, Terry T. Conway, Gary Lim, James Leslie Douotas, Terrence W. Doyle, Marcel Menard, Denis Cimon, Pierre Rivest, Donald E. Horning
Publikováno v:
Canadian Journal of Chemistry. 56:1335-1341
The synthesis of 7β-(-2′-thienylacetamido)-3-acetoxymethyl-Δ3-O-2-isocepheni-4-carboxylic acid (17) is described. Thus treatment of enol mesylate 3a or triflate 3b with triethylamine gave the allene 4 which gave the diiodide upon treatment with i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5415d821d62d3b5ffe9bee718bbba394
https://doi.org/10.1139/v78-221
https://doi.org/10.1139/v78-221