Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Terry Panchal"'
Autor:
Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox, Maurizio Delcanale
Publikováno v:
Journal of Medicinal Chemistry. 65:7170-7192
The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identifi
A direct and versatile route for the reliable synthesis of trans-2,5-disubstituted pyrrolidines from pyroglutamic acid is reported, which can be conducted at scale and without chromatographic purification of key intermediates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0a56c62474cbdc2560180ff9ec0c8b
https://doi.org/10.1039/b611583g
https://doi.org/10.1039/b611583g
Autor:
Karen Louise Philpott, Robert J. Watson, Jason Witherington, Greg J. Osborne, Terry Panchal, Simon Taylor, Nigel Deeks, Tom D. Heightman, James Gray, Umesh Kumar, Simon J. Dowell, Pam Gaskin, Lee Andrew Harrison, Robert Willis, Colin A. Campbell, Sandra Arpino, Sapna Desai, Rino A. Bit, Mary A. Morse, Emmanuel Hubert Demont, Andrea C. Haynes, Philip G. Humphreys, Duncan S. Holmes
Publikováno v:
Journal of Medicinal Chemistry. 54:6724-6733
2-Amino-2-(4-octylphenethyl)propane-1,3-diol 1 (fingolimod, FTY720) has been recently marketed in the United States for the treatment of patients with remitting relapsing multiple sclerosis (RRMS). Its efficacy has been primarily linked to the agonis
Autor:
Andrea C. Haynes, Benjamin I. Andrews, Bela Rajiv Patel, Jason Witherington, Mary A. Morse, Umesh Kumar, Colin A. Campbell, Pam Gaskin, Sapna Desai, Robert Willis, Jason W. B. Cooke, Greg J. Osborne, Simon Taylor, Robert J. Watson, Terry Panchal, Alcide Perboni, Nigel Deeks, James Gray, Simon J. Dowell, Duncan S. Holmes, Rino A. Bit, Emmanuel Hubert Demont
Publikováno v:
ACS Medicinal Chemistry Letters. 2:444-449
Gilenya (fingolimod, FTY720) was recently approved by the U.S. FDA for the treatment of patients with remitting relapsing multiple sclerosis (RRMS). It is a potent agonist of four of the five sphingosine 1-phosphate (S1P) G-protein-coupled receptors
Autor:
Robert Lafferty, Tracey Yi, Ross G. Bentley, Dennis Lee, Sanjay S. Khandekar, Christine Webb, Joseph P. Marino, Mark James Bamford, Gary K. Smith, Erding Hu, Robert N. Willette, Zunxuan Chen, Robert B. Kirkpatrick, Eugene T. Grygielko, Robert A. Stavenger, David J. Behm, Larry J. Jolivette, Lois L. Wright, David Kendall Jung, Terry Panchal, Chris P. Doe, Edward Dul
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:89-98
Increased Rho kinase (ROCK) activity contributes to smooth muscle contraction and regulates blood pressure homeostasis. We hypothesized that potent and selective ROCK inhibitors with novel structural motifs would help elucidate the functional role of
Autor:
Angela Worby, Mark James Bamford, David Matthew Wilson, Christopher A. Parr, Susannah Davis, Andrew R. Calver, James Apps, Andrew D. Medhurst, Brenda K. Trail, Andrew K. Takle, David Kenneth Dean, Michael A. Briggs, Tom D. Heightman, Trevor White, Isabel Jm Beresford, Tania O. Stean, Robert P. Davis, Sanjeet Singh Sehmi, Terry Panchal, Leanne Harris, Nigel Quashie, Barry Crook, Jon Graham Anthony Steadman, Jason Witherington, Joanne Schogger, Nicholas Bailey
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
This Letter describes the discovery of a novel series of H3 receptor antagonists. The initial medicinal chemistry strategy focused on deconstructing and simplifying an early screening hit which rapidly led to the discovery of a novel series of H3 rec
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 61:o42-o44
The crystal structure of the title bicyclic oxazolidindione, C7H6Cl3NO3, confirmed the absolute stereochemistry as 2R,5S.
Autor:
Andrew K. Takle, Gail Hutley, Neil Stuart Garton, Terry Panchal, Thomas George Christopher Hayhow, Emmanuel Hubert Demont, Delphine Brissy, Mark James Bamford, Irene Farre-Gutierrez, Joanna Brookfield, Nicholas Bailey, Richard L. Elliott, David J. Spalding, Antoinette Naylor, Hui-Xian Seow
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(13)
Acid pump antagonists (APAs) such as the imidazo[1,2-a]pyridine AZD-0865 2 have proven efficacious at low oral doses in acid related gastric disorders. Herein we describe some of the broader SAR in this class of molecule and detail the discovery of a