Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Terry MacIntyre"'
Autor:
Terry Macintyre
Speaking at West Point in 1962, Dean Acheson observed that Britain had lost an empire and had still to find a new role. This book explains why, in the following years, as Britain's Labour government contemplated withdrawal from east of Suez, minister
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
Figure S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444106ead769434517a6030981d594b4
https://doi.org/10.1158/1078-0432.22476393.v1
https://doi.org/10.1158/1078-0432.22476393.v1
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
contains methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f66d7cdc5a26035ed01be67bc7dad53
https://doi.org/10.1158/1078-0432.22476381.v1
https://doi.org/10.1158/1078-0432.22476381.v1
Autor:
Patrick A. Zweidler-McKay, Lizhi Zeng, Peter E. Zage, Charles Omer, Kevin Webster, Jeffrey L. Brown, Tao Wang, Ethan Hoffmann, Zhong-Ying Liu, Dave Whitston, Haiyun Wang, Terry MacIntyre, Kenneth Thress
Tropomyosin-related kinases (TrkA, TrkB, and TrkC) are receptor tyrosine kinases that, along with their ligands, the neurotrophins, are involved in neuronal cell growth, development, and survival. The Trk-neurotrophin pathway may also play a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65b0cf23fb0cb49c94c32ad39f481c3
https://doi.org/10.1158/1535-7163.c.6532115
https://doi.org/10.1158/1535-7163.c.6532115
Autor:
Patrick A. Zweidler-McKay, Lizhi Zeng, Peter E. Zage, Charles Omer, Kevin Webster, Jeffrey L. Brown, Tao Wang, Ethan Hoffmann, Zhong-Ying Liu, Dave Whitston, Haiyun Wang, Terry MacIntyre, Kenneth Thress
Supplementary Fig. S3 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a818a25db130bda28d45da9b7537835
https://doi.org/10.1158/1535-7163.22485878
https://doi.org/10.1158/1535-7163.22485878
Autor:
Patrick A. Zweidler-McKay, Lizhi Zeng, Peter E. Zage, Charles Omer, Kevin Webster, Jeffrey L. Brown, Tao Wang, Ethan Hoffmann, Zhong-Ying Liu, Dave Whitston, Haiyun Wang, Terry MacIntyre, Kenneth Thress
Supplementary Table S1 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2926fae9fcc16d8d8f59959f0274c961
https://doi.org/10.1158/1535-7163.22485872
https://doi.org/10.1158/1535-7163.22485872
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
Purpose:Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8844690ddeffa8863fd595c34c80f01
https://doi.org/10.1158/1078-0432.c.6529392
https://doi.org/10.1158/1078-0432.c.6529392
Autor:
Shenghua Wen, Srividya B. Balachander, Francis D. Gibbons, Michael Zinda, William McCoull, Nancy Su, Barry R. Davies, Stephen E. Kurtz, Terry MacIntyre, Edward J. Hennessy, Martin Wild, Paula Lewis, Ricky W. Johnstone, Jamal Carlos Saeh, Kathleen A. Burke, Omid Tavana, Andrea Newbold, Elizabeth A. Coker, Alwin Schuller, Justin Cidado, Diebold R Bruce, Tristan J. Lubinski, Steven Criscione, J. Paul Secrist, Kate Byth, Gareth P. Gregory, Deborah Lawson, Ammar Adam, Shannon K. McWeeney, Stephen Fawell, Thomas Gero, Jeffrey G. Varnes, Eric Gangl, Patricia Jaaks, Jeffrey W. Tyner, Mathew J. Garnett, Areya Tabatabai, Stephanos Ioannidis
Publikováno v:
Clinical Cancer Research. 26:6535-6549
Purpose: Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::564420d79c6feacf9af617f03b6937bc
https://doi.org/10.1158/1078-0432.ccr-20-0863
https://doi.org/10.1158/1078-0432.ccr-20-0863
Autor:
Srividya B, Balachander, Steven W, Criscione, Kate F, Byth, Justin, Cidado, Ammar, Adam, Paula, Lewis, Terry, Macintyre, Shenghua, Wen, Deborah, Lawson, Kathleen, Burke, Tristan, Lubinski, Jeffrey W, Tyner, Stephen E, Kurtz, Shannon K, McWeeney, Jeffrey, Varnes, R Bruce, Diebold, Thomas, Gero, Stephanos, Ioannidis, Edward J, Hennessy, William, McCoull, Jamal C, Saeh, Areya, Tabatabai, Omid, Tavana, Nancy, Su, Alwin, Schuller, Mathew J, Garnett, Patricia, Jaaks, Elizabeth A, Coker, Gareth P, Gregory, Andrea, Newbold, Ricky W, Johnstone, Eric, Gangl, Martin, Wild, Michael, Zinda, J Paul, Secrist, Barry R, Davies, Stephen E, Fawell, Francis D, Gibbons
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(24)
Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2-selective inhibitor, has had success in the clinic, another family member, Bcl-xWe used structure-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a85a5f05ec69d49e1282eb570e6bdc06
https://pubmed.ncbi.nlm.nih.gov/32988967
https://pubmed.ncbi.nlm.nih.gov/32988967
Autor:
Kate Byth, Daniel John Russell, Jamal Carlos Saeh, Terry MacIntyre, Stephanos Ioannidis, Thomas Gero, Diebold R Bruce, Galina Repik, Paul T. Grover, Ogoe Claude Afona, Mei Su, Jeffrey G. Varnes, Prasenjit Mukherjee, Shan Huang, Keith Dillman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3026-3033
Structural modifications of the left-hand side of compound 1 were identified which retained or improved potent binding to Bcl-2 and Bcl-xL in in vitro biochemical assays and had strong activity in an RS4;11 apoptotic cellular assay. For example, sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f19cec2e34e8552a5681ee019d02c01
https://doi.org/10.1016/j.bmcl.2014.05.036
https://doi.org/10.1016/j.bmcl.2014.05.036