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Akademický článek

In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation

Autor: Thorne Leigh, Holder Thomas, Ramsay Andrew, Edwards Jane, Taema Maged, Windl Otto, Maddison Ben Charles, Gough Kevin Christopher, Terry Linda Ann

Publikováno v: BMC Veterinary Research, Vol 8, Iss 1, p 223 (2012)

Abstract Background Protein misfolding cyclic amplification (PMCA) is a method that facilitates the detection of prions from many sources of transmissible spongiform encephalopathy (TSE). Sheep scrapie represents a unique diversity of prion disease a

Externí odkaz: https://doaj.org/article/9bcaf064e5c34b1bb121f008dd353a56

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Akademický článek

The interpretation of disease phenotypes to identify TSE strains following murine bioassay: characterisation of classical scrapie

Autor: Beck Katy E, Vickery Christopher M, Lockey Richard, Holder Thomas, Thorne Leigh, Terry Linda A, Denyer Margaret, Webb Paul, Simmons Marion M, Spiropoulos John

Publikováno v: Veterinary Research, Vol 43, Iss 1, p 77 (2012)

Abstract Mouse bioassay can be readily employed for strain typing of naturally occurring transmissible spongiform encephalopathy cases. Classical scrapie strains have been characterised historically based on the established methodology of assessing i

Externí odkaz: https://doaj.org/article/4f7f570ebd0249a1a87463b6b68a0bfd

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Akademický článek

Detection of prions in the faeces of sheep naturally infected with classical scrapie

Autor: Terry Linda A, Howells Laurence, Bishop Keith, Baker Claire A, Everest Sally, Thorne Leigh, Maddison Ben C, Gough Kevin C

Publikováno v: Veterinary Research, Vol 42, Iss 1, p 65 (2011)

Abstract Classical scrapie is a naturally transmitted prion disease of sheep and goats. Contaminated environments may contribute to the spread of disease and evidence from animal models has implicated urine, blood, saliva, placenta and faeces as poss

Externí odkaz: https://doaj.org/article/070625853c6941068a750c05e912c185

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Akademický článek

Idiopathic Brainstem Neuronal Chromatolysis (IBNC): a novel prion protein related disorder of cattle?

Autor: Martin Stuart, Perez Belinda, Jeffrey Martin, Terry Linda, González Lorenzo

Publikováno v: BMC Veterinary Research, Vol 4, Iss 1, p 38 (2008)

Abstract Background The epidemic form of Bovine Spongiform Encephalopathy (BSE) is generally considered to have been caused by a single prion strain but at least two strain variants of cattle prion disorders have recently been recognized. An addition

Externí odkaz: https://doaj.org/article/2dbf1ef408a54d36a904705d4ecbfe1f

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