The extensive solid-form landscape of sulfathiazole: hydrogen-bond topology and node shape

Autor: David S. Hughes, Ann L. Bingham, Michael B. Hursthouse, Terry L. Threlfall, Andrew D. Bond

Patterns of N-H⋯O and N-H⋯N hydrogen bonds are described in a set of 101 crystal structures containing sulfathiazole (SLFZ). The structure set comprises five SLFZ polymorphs, 63 co-crystals, 30 salts and three other structures, standardised by ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971bd8124591a7fea96e7a844d251c39
https://eprints.soton.ac.uk/475336/

Flow cell to study crystallisation processes in-situ using terahertz time-domain spectroscopy

Autor: Johanna Kölbel, Terry L. Threlfall, Axel Zeitler, Qi Li

A versatile setup based on terahertz time-domain spectroscopy was developed to monitor the process of crystallisation and characterise the structure of the crystals as well as the dynamics of the solvent in situ. The setup can be used to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac5f30525428042b3961e80f6f96202
https://doi.org/10.26434/chemrxiv-2021-mnchm

The Curious Case of Acetaldehyde Phenylhydrazone: Resolution of a 120 Year Old Puzzle where Forms with Vastly Different Melting Points Have the Same Structure

Autor: Simon J. Coles, Manuel E. Minas da Piedade, Hugo Meekes, Carlos Bernades, Mateusz B. Pitak, Ernst R. H. van Eck, Leyla-Cann Sögütoglu, Marina Carravetta, Terry L. Threlfall, Mike Podmore, René R. E. Steendam, Tobian A. H. de Ruiter

Publikováno v: Crystal Growth & Design, 19, 2, pp. 907-917
Crystal Growth & Design, 19, 907-917

The solid forms of acetaldehyde phenylhydrazone were investigated in detail over a century ago, with curious results: it was reported that a low melting form could be transformed into a high melting form by trace alkali, and the reverse process could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c674c9bec610b1e52fdc2effd4516c70
https://doi.org/10.1021/acs.cgd.8b01459

Structural and Thermodynamic Explanations of Ostwald's Rule

Autor: Terry L. Threlfall

Publikováno v: Organic Process Research & Development. 7:1017-1027

Ostwald proposed that the solid first formed on crystallisation of a melt or a solution would be the least stable polymorph. It is shown that this can be rationalized on the basis of irreversible thermodynamics, structural relationships, or a combine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80295e8c02aaafafcae4dffd615a112e
https://doi.org/10.1021/op030026l

Characterization of Temperature Induced Phase Transitions in the Five Polymorphic Forms of Sulfathia-zole by Terahertz Pulsed Spectroscopy and Differential Scanning Calorimetry

Autor: Philip F. Taday, Thomas Rades, Rolf W. Berg, Michael Pepper, Keith C. Gordon, Clare J. Strachan, David A. Newnham, Terry L. Threlfall, J. Axel Zeitler, Robert W. Lancaster

Publikováno v: Zeitler, J A, Newnham, D A, Taday, P F, Threlfall, T L, Lancaster, R W, Berg, R W, Strachan, C J, Pepper, M, Gordon, K C & Rades, T 2006, ' Characterization of Temperature Induced Phase Transitions in the Five Polymorphic Forms of Sulfathia-zole by Terahertz Pulsed Spectroscopy and Differential Scanning Calorimetry ', Journal of Pharmaceutical Sciences, vol. 95, no. 11, pp. 2486-2498 . https://doi.org/10.1002/jps.20719

The far-infrared properties of all five known polymorphic forms of the drug sulfathiazole have been studied by terahertz pulsed spectroscopy and low-frequency Raman spectroscopy. The observed spectra of the different polymorphs are distinctly differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92c4148f4744ac4588099c44783805b
https://orbit.dtu.dk/en/publications/046b7395-305b-46b5-a34c-bac13193d1e1