Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Terry L, Bowlin"'
Autor:
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are e
Externí odkaz:
https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
Autor:
Eric G. Romanowski, Islam T. M. Hussein, Steven C. Cardinale, Michelle M. Butler, Lucas R. Morin, Terry L. Bowlin, Kathleen A. Yates, Robert M. Q. Shanks, Regis P. Kowalski
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 294 (2021)
Presently, there is no FDA- or EMA-approved antiviral for the treatment of human adenovirus (HAdV) ocular infections. This study determined the antiviral activity of filociclovir (FCV) against ocular HAdV isolates in vitro and in the Ad5/NZW rabbit o
Externí odkaz:
https://doaj.org/article/f4aedeca347e483ea6d1012c90d03a5e
Autor:
Michelle M Butler, Samanthi L. Waidyarachchi, Jinfeng Shao, Son T. Nguyen, Xiaoyuan Ding, Steven C. Cardinale, Lucas R. Morin, Steven M. Kwasny, Mai Ito, Jeanine Gezelle, Maria B. Jiminez-Diaz, Inigo Angulo-Barturen, Robert T. Jacobs, Jeremy N. Burrows, Zachary D. Aron, Terry L. Bowlin, Sanjay A. Desai
Publikováno v:
Mol Pharmacol
Human and animal malaria parasites increase their host erythrocyte permeability to a broad range of solutes as mediated by parasite-associated ion channels. Molecular and pharmacological studies have implicated an essential role in parasite nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd2cfbfaccb951c5eceaee13a146c87
https://europepmc.org/articles/PMC9450958/
https://europepmc.org/articles/PMC9450958/
Autor:
Andrea J. Parsons, Sabrina I. Ophir, Thomas J. Gardner, Jailene Casado Paredes, Kathryn R. Stein, Steven M. Kwasny, Steven C. Cardinale, Matthew Torhan, Mark N. Prichard, Scott H. James, Kristina E. Atanasoff, Narendran G-Dayanandan, Terry L. Bowlin, Timothy J. Opperman, Domenico Tortorella
Publikováno v:
Antiviral Research. 209:105474
Human cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes latent asymptomatic infections in healthy individuals but can cause serious infections in immunocompromised people, resulting in increased risk of morbidity and mortality. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efc4316f8c6a98fd65200109a1564e
https://doi.org/10.1016/j.antiviral.2022.105474
https://doi.org/10.1016/j.antiviral.2022.105474
Autor:
Terry L. Bowlin, Donald T. Moir, Michelle M. Butler, James C. Burnett, Bing Li, Norton P. Peet
Publikováno v:
Molecules, Vol 16, Iss 1, Pp 202-220 (2010)
Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, le
Externí odkaz:
https://doaj.org/article/d719bdd325de4d4b8f36262565b81756
Publikováno v:
Antiviral Research. 208:105431
Clusters of acute non HepA-E hepatitis cases in previously healthy children have been reported globally. At least, 1010 cases were identified in 35 countries, 5% of those cases required liver transplantation and 2% died. The exact cause is not yet kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210561a620c24cf46108bd01b71e5f81
https://doi.org/10.1016/j.antiviral.2022.105431
https://doi.org/10.1016/j.antiviral.2022.105431
Autor:
Rekha G. Panchal, Margaret M. Lemmon, Michelle M. Butler, Christopher J. Meyer, Samanthi L. Waidyarachchi, Terry L. Bowlin, Richard E. Lee, Weirui Chai, Jiuyu Liu, Douglas Lane, Jennifer M. Scarff
Publikováno v:
The Journal of Antibiotics
New antibiotics that are active against multi-drug-resistant strains and difficult-to-treat bacterial infections are needed. Synthetic modification of spectinomycin, a bacterial protein synthesis inhibitor, has been shown to increase antibacterial ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9dd118c90ff7677bdd000dfb97d8f7
https://doi.org/10.1038/s41429-019-0194-8
https://doi.org/10.1038/s41429-019-0194-8
Autor:
Atousa Mehrani, Mynthia Cabrera, Kenneth C. Keiler, Michelle M. Butler, Steven M. Kwasny, Pooja Srinivas, Lucas R. Morin, Divya Hosangadi, John N. Alumasa, Jay S. Barbor, Steven C. Cardinale, Scott M. Stagg, Zachary D. Aron, Christine M. Dunham, Ann E. Jerse, Matthew C. Torhan, Timothy J. Opperman, Eric D. Hoffer, Terry L. Bowlin, Kristie L. Connolly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411f83145a0e100fbdf1e585bbf3dfa6
https://doi.org/10.1038/s41467-021-22012-7
https://doi.org/10.1038/s41467-021-22012-7
Publikováno v:
Drug discovery today. 26(9)
The increasing prevalence of multidrug-resistant (MDR) bacterial infections has created a crucial need for new therapeutics that avoid or minimize existing resistance mechanisms. In this review, we describe the development of novel classes of small-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84f4c5a829015ecb4d8140706acacb4
https://pubmed.ncbi.nlm.nih.gov/33845218
https://pubmed.ncbi.nlm.nih.gov/33845218
Publikováno v:
Antiviral Res
MBX-2168 has a mechanism of action similar to that of acyclovir (ACV) and ganciclovir (GCV), but two unique steps differentiate this drug from ACV/GCV. First, MBX-2168 is, at least partially, phosphorylated by the endogenous cellular kinase TAOK3 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6412f59aa3d99758054a43d32d5180d
https://pubmed.ncbi.nlm.nih.gov/33476709
https://pubmed.ncbi.nlm.nih.gov/33476709