Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Terry K, Smith"'
Autor:
Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Sets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity. A unified synthesis of skeletally-diverse sulfonyl fluorides was developed t
Externí odkaz:
https://doaj.org/article/6ec208982da44492ac48af9d71880026
Autor:
Stephen R. Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R. Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K. Smith, Susan M. Lea, Tracy Palmer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The type VII protein secretion system (T7SS) is found in many Gram-positive bacteria and in pathogenic mycobacteria. All T7SS substrate proteins described to date share a common helical domain architecture at the N-terminus that typically in
Externí odkaz:
https://doaj.org/article/614445c295ff47b0b6acfe1519669f17
Autor:
Nailma S A Dos Santos, Carlos F Estevez-Castro, Juan P Macedo, Daniela F Chame, Thiago Castro-Gomes, Mariana Santos-Cardoso, Gabriela A Burle-Caldas, Courtney N Covington, Patrick G Steel, Terry K Smith, Paul W Denny, Santuza M R Teixeira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011646 (2023)
Sphingolipids (SLs) are essential components of all eukaryotic cellular membranes. In fungi, plants and many protozoa, the primary SL is inositol-phosphorylceramide (IPC). Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD), a c
Externí odkaz:
https://doaj.org/article/59bb370ad8bb491b8ca365e30536662c
Autor:
Stephen J. Hierons, Kazim Abbas, Amélie I. S. Sobczak, Michela Cerone, Terry K. Smith, Ramzi A. Ajjan, Alan J. Stewart
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Obesity is a complex disease that increases an individual’s risk of developing other diseases and health-related problems. A common feature is dyslipidemia characterized by increased levels of plasma lipids, which include non-esterified fa
Externí odkaz:
https://doaj.org/article/f5d49af16dc54d819bbb745b644ba1f8
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011147 (2023)
Host-specific plant pathogens must coordinate their life cycles with the availability of a host plant. Although this is frequently achieved through a response to specific chemical cues derived from the host plant, little is known about the molecular
Externí odkaz:
https://doaj.org/article/a9b4fc910a0e47ba914e9774cc4dd749
Autor:
Fernanda V Cabral, Michela Cerone, Saydulla Persheyev, Cheng Lian, Ifor D W Samuel, Martha S Ribeiro, Terry K Smith
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0289492 (2023)
The emergence of drug resistance in cutaneous leishmaniasis (CL) has become a major problem over the past decades. The spread of resistant phenotypes has been attributed to the wide misuse of current antileishmanial chemotherapy, which is a serious t
Externí odkaz:
https://doaj.org/article/983c0bd0a0e042daba0d098a0e8649b8
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Crithidia fasiculata belongs to the trypanosomatidae order of protozoan parasites, bearing close relation to other kinetoplastid parasites such as Trypanosoma brucei and Leishmania spp. As an early diverging lineage of eukaryotes, the study of kineto
Externí odkaz:
https://doaj.org/article/dbe0eb627e6242c28724f4092856401e
Publikováno v:
Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-17 (2020)
Abstract Background Lipid dysregulation is associated with several key characteristics of Alzheimer’s disease (AD), including amyloid-β and tau neuropathology, neurodegeneration, glucose hypometabolism, as well as synaptic and mitochondrial dysfun
Externí odkaz:
https://doaj.org/article/933b20ad671746a58c50281520036f2b
Autor:
Adriana Temporão, Margarida Sanches-Vaz, Rafael Luís, Helena Nunes-Cabaço, Terry K. Smith, Miguel Prudêncio, Luisa M. Figueiredo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
Malaria, a disease caused by Plasmodium parasites, remains a major threat to public health globally. It is the most common disease in patients with sleeping sickness, another parasitic illness, caused by Trypanosoma brucei. We have previously shown t
Externí odkaz:
https://doaj.org/article/5eaf28c1c3664433b188f94e8f25947e
Autor:
Paige Garrison, Umaer Khan, Michael Cipriano, Peter J. Bush, Jacquelyn McDonald, Aakash Sur, Peter J. Myler, Terry K. Smith, Stephen L. Hajduk, James D. Bangs
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific pho
Externí odkaz:
https://doaj.org/article/bf9bd0020fb4404db69135c5e3a5c6f5