Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Terry I, Guinter"'
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7
Autor:
Jan Wisniewski, Terry I. Guinter, John H. Kehrl, Yuan Zhuang, Tejas Kadakia, Xuguang Tai, Il-Young Hwang, Michael J. Kruhlak, Sumedha Roy, Alfred Singer, Amala Alag
Publikováno v:
The Journal of Experimental Medicine
The E-protein transcription factors E2A and HEB regulate thymocyte expression of the chemokine receptor CXCR4 to retain preselection thymocytes in the thymic cortex. TCR-mediated positive selection signals extinguish CXCR4 expression to allow positiv
Autor:
Terry I. Guinter, Mirelle Rojano, Britta Engelhardt, Ingrid Saba, James Chih-Hsin Yang, Abhisek Bhattacharya, Jinghua Lu, Ken-ichi Hanada, Amala Alag, Alfred Singer, François Van Laethem, Peter D. Sun, Jennifer M. Ashe, Xuguang Tai
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Autor:
Tejas Kadakia, Ruth Etzensperger, Takeshi Egawa, Terry I. Guinter, Amala Alag, Alfred Singer, Xuguang Tai, Batu Erman
Publikováno v:
Nature Immunology. 18:1218-1227
T cell antigen receptor (TCR) signaling in the thymus initiates positive selection, but the CD8+-lineage fate is thought to be induced by cytokines after TCR signaling has ceased, although this remains controversial and unproven. We have identified f
Autor:
Leonid A. Pobezinsky, Terry I. Guinter, Motoko Y. Kimura, Tejas Kadakia, Amala Alag, Alfred Singer, Ruth Etzensperger, Susanna Jeurling, Tom M. McCaughtry, Susan O. Sharrow, Lionel Feigenbaum
Publikováno v:
Nature immunology
Lethal-7 (let-7) microRNAs (miRNAs) are the most abundant miRNAs in the genome, but their role in developing thymocytes is unclear. We found that let-7 miRNAs targeted Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to post
Autor:
Ruth, Etzensperger, Tejas, Kadakia, Xuguang, Tai, Amala, Alag, Terry I, Guinter, Takeshi, Egawa, Batu, Erman, Alfred, Singer
Publikováno v:
Nature immunology
T cell antigen receptor (TCR) signaling in the thymus initiates positive selection but CD8 lineage fate is thought to be induced by cytokines after TCR signaling has ceased, although this remains controversial and unproven. We now identify four non-c
Autor:
Alfred Singer, Terry I. Guinter, Motoko Y. Kimura, Lionel Feigenbaum, Anthony J. Adams, Anastasia N. Tikhonova, François Van Laethem, Xuguang Tai, Susan O. Sharrow, Cecile Le Saout, Leonid A. Pobezinsky, Günter Bernhardt
Publikováno v:
Cell. 154:1326-1341
Summary Thymic selection requires signaling by the protein tyrosine kinase Lck to generate T cells expressing αβ T cell antigen receptors (TCR). For reasons not understood, the thymus selects only αβTCR that are restricted by major histocompatibi
Autor:
Dinah S. Singer, Jie Mu, Terry I. Guinter, Motoko Y. Kimura, Ruth Etzensperger, Batu Erman, Lionel Feigenbaum, Gil Katz, Tom M. McCaughtry, Xuguang Tai, Alfred Singer, Amala Alag
Publikováno v:
Immunity. 38:1116-1128
SummaryImmune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of Treg cell development and function. We report here that Foxp3 was lethal to develop
Autor:
Alfred Singer, Terry I. Guinter, Motoko Y. Kimura, Ruth Etzensperger, Paul E. Love, Julien Thomas, Miho Shinzawa, Toshinori Nakayama, Zhenhu Li, Xuguang Tai
Publikováno v:
Nature immunology. 17(12)
Major histocompatibility complex class I (MHC I) positive selection of CD8(+) T cells in the thymus requires that T cell antigen receptor (TCR) signaling end in time for cytokines to induce Runx3d, the CD8-lineage transcription factor. We examined th
Autor:
Enrico, Brugnera, Avinash, Bhandoola, Ricardo, Cibotti, Qing, Yu, Terry I, Guinter, Yoshio, Yamashita, Susan O, Sharrow, Alfred, Singer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(5)