Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Terry D, Foutz"'
Autor:
Li Luo, T Fabiola Miscioscia, Jake Strouse, Charuta C. Palsuledesai, Susan Young, Cristian Bologa, Harold A. Ames, Ramona Curpan, Orazio Nicolotti, Tudor I. Oprea, Bruce S. Edwards, Angela Wandinger-Ness, Virginia M. Salas, Zhanna Galochkina, Oleg Ursu, Anna Waller, Mark B. Carter, Yuna Guo, Mark K. Haynes, Larry A. Sklar, Zurab Surviladze, Elsa Romero, Yang Wu, Terry D. Foutz
Publikováno v:
ACS chemical biology. 13(6)
Ras and Ras-related small GTPases are key regulators of diverse cellular functions that impact cell growth, survival, motility, morphogenesis, and differentiation. They are important targets for studies of disease mechanisms as well as drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b4e73bea64eddf8a45bba74a3d88c7
https://pubmed.ncbi.nlm.nih.gov/29746086
https://pubmed.ncbi.nlm.nih.gov/29746086
Autor:
Terry D. Foutz, Alexandre Chigaev, Bruce S. Edwards, Gordon J. Zwartz, Denise Dwyer, Larry A. Sklar
Publikováno v:
Journal of Biological Chemistry. 279:38277-38286
Shear promotes endothelial recruitment of leukocytes, cell activation, and transmigration. Mechanical stress on cells caused by shear can induce a rapid integrin conformational change and activation, followed by an increase in binding to the extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e5bd8eeb93350bbed3f483e01ce704
https://doi.org/10.1074/jbc.m402944200
https://doi.org/10.1074/jbc.m402944200
Autor:
Eric R. Prossnitz, Sean M. Biggs, Wei-Jen Tang, Anna Waller, Larry A. Sklar, Richard R. Neubig, Qing Guo, Daniel F. Cimino, Peter C. Simons, Terry D. Foutz
Publikováno v:
Journal of Biological Chemistry. 279:13514-13521
We developed a novel and generalized approach to investigate G protein-coupled receptor molecular assemblies. We solubilized a fusion protein consisting of the β2-adrenergic receptor and green fluorescent protein (GFP) for bead-based flow cytometric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca42c8ef4dc42046ab590c63d4efcfb9
https://doi.org/10.1074/jbc.m310306200
https://doi.org/10.1074/jbc.m310306200
Autor:
Alexandre Chigaev, Richard G. Posner, Gordon J. Zwartz, Richard S. Larson, Terry D. Foutz, Larry A. Sklar
Publikováno v:
Biophysical Journal. 86(2):1243-1252
The rate of leukocyte recruitment to and detachment from the vasculature contributes to cellular tethering, rolling, firm adherence, and migration across an endothelium layer. The molecular rates depend on the type and number of bound integrin or sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685e4facc3c3052d01db12a1c36293d9
Autor:
Vsevolod V. Gurevich, Daniel F. Cimino, Mei Shi, Diane C. Maestas, Teresa A. Bennett, Terry D. Foutz, Larry A. Sklar, Eric R. Prossnitz
Publikováno v:
Biochemistry. 42:7283-7293
G protein-coupled receptors (GPCRs) must constantly compete for interactions with G proteins, kinases, and arrestins. To evaluate the interactions of these proteins with GPCRs in greater detail, we generated a fusion protein between the N-formyl pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39da04104d3935570d095eaa74771614
https://doi.org/10.1021/bi0341657
https://doi.org/10.1021/bi0341657
Autor:
Vsevolod V. Gurevich, Terry D. Foutz, Teresa A. Bennett, Eric R. Prossnitz, T. Alexander Key, Larry A. Sklar
Publikováno v:
Journal of Biological Chemistry. 276:49204-49212
Although heptahelical chemoattractant and chemokine receptors are known to play a significant role in the host immune response and the pathophysiology of disease, the molecular mechanisms and transient macroassemblies underlying their activation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f75b0b07b0904d37d13461a4474713
https://doi.org/10.1074/jbc.m109475200
https://doi.org/10.1074/jbc.m109475200
Autor:
Gregory W. Fisher, Peter C. Simons, Phillip H. Tapia, Alan S. Waggoner, Larry A. Sklar, Yang Wu, Terry D. Foutz, Jonathan W. Jarvik, J. Jacob Strouse
Publikováno v:
Molecular pharmacology. 82(4)
We developed a platform combining fluorogen-activating protein (FAP) technology with high-throughput flow cytometry to detect real-time protein trafficking to and from the plasma membrane in living cells. The hybrid platform facilitates drug discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d461b6e4bd53112918b191f4d3300c
https://pubmed.ncbi.nlm.nih.gov/22828801
https://pubmed.ncbi.nlm.nih.gov/22828801
Autor:
Larry A. Sklar, Robbie Loewith, Margaret Werner-Washburne, Tuanli Yao, J. Jacob Strouse, Nicolas Panchaud, Chris Allen, Oleg Ursu, Marie-Pierre Péli-Gulli, Jun Chen, Jeffrey Aubé, Mark B. Carter, Susan M. Young, Huining Kang, Bruce S. Edwards, Jennifer E. Golden, Anna Waller, Blake R. Peterson, Cristian Bologa, Andrew Seeber, Claudio De Virgilio, Terry D. Foutz
Publikováno v:
ACS Chemical Biology, Vol. 7, No 4 (2012) pp. 715-22
ACS chemical biology
ACS Chemical Biology
ACS chemical biology
ACS Chemical Biology
TOR (target of rapamycin) is a serine/threonine kinase, evolutionarily conserved from yeast to human, which functions as a fundamental controller of cell growth. The moderate clinical benefit of rapamycin in mTOR-based therapy of many cancers favors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33ab282d04033750ec895863a0d7781
https://archive-ouverte.unige.ch/unige:26555
https://archive-ouverte.unige.ch/unige:26555
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 79(3)
Extracellular hydrodynamic forces may be transmitted to the interior of cells through the alteration of integrin conformation and affinity. Integrin activation regulates leukocyte recruitment, cell activation, and transmigration. The cellular and mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5079b1ae0529c8faabbaaa12df1edb58
https://pubmed.ncbi.nlm.nih.gov/22045643
https://pubmed.ncbi.nlm.nih.gov/22045643
Autor:
William E. McIntire, Mei Shi, Terry D. Foutz, Jeremy Lewis, Peter C. Simons, Daniel F. Cimino, James C. Garrison, Eric R. Prossnitz, Tione Buranda, Larry A. Sklar, William K. Lim, Richard R. Neubig
Publikováno v:
Molecular pharmacology. 64(5)
G protein-coupled receptors form a ternary complex of ligand, receptor, and G protein heterotrimer (LRG) during signal transduction from the outside to the inside of a cell. Our goal was to develop a homogeneous, small-volume, bead-based approach com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a4465707f76f844f5942e4f7eba481
https://pubmed.ncbi.nlm.nih.gov/14573773
https://pubmed.ncbi.nlm.nih.gov/14573773