Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Terry C. Orton"'
Autor:
Kassiani Kalaitzi, Alison J. Foster, James E. Sidaway, Brian G. Lake, Terry C. Orton, Huw B. Jones
Publikováno v:
Toxicology. 430:152343
In this study liver tumours produced in male and female mice of the low spontaneous liver tumour incidence C57BL/10J strain treated for 99 weeks with 1000 ppm in the diet with the model constitutive androstane receptor (CAR) activator sodium phenobar
Publikováno v:
Food and Chemical Toxicology. 47:1333-1340
The hepatocarcinogenicity of sodium phenobarbitone (PB) was studied in male and female mice of the low spontaneous liver tumour incidence C57BL/10 J strain. Treatment with 200 and 1000 ppmPB for 1 month increased relative liver weight in both sexes,
Autor:
Alan M. Marsden, F R Westwood, James E. Sidaway, Terry C. Orton, Robert C. Scott, C T Azuma, Y Wang
Publikováno v:
Xenobiotica. 39:90-98
Rare instances of myopathy are associated with all statins, but cerivastatin was withdrawn from clinical use due to a greater incidence of myopathy. The mechanism of statin-induced myopathy with respect to tissue disposition was investigated by measu
Autor:
Rachel Rowlinson, Andrew Craig, Robert Tonge, David A. Jackson, Ian D. Wilson, James E. Sidaway, Janice Nickson, Jeremy K. Nicholson, Terry C. Orton, Elaine Holmes
Publikováno v:
Journal of Proteome Research. 5:1586-1601
Administration of high doses of the histamine antagonist methapyrilene to rats causes periportal liver necrosis. The mechanism of toxicity is ill-defined and here we have utilized an integrated systems approach to understanding the toxic mechanisms b
Publikováno v:
Toxicology. 206:91-109
Tamoxifen has long been the endocrine treatment of choice for women with breast cancer and is now employed for prophylactic use in women at high risk from breast cancer. Other selective estrogen receptor modulators (SERMs), such as raloxifene, mimic
Autor:
Andrew A. Wylie, David J. Pulford, Alison McVie-Wylie, Yuan-Tsong Chen, Randy L. Jirtle, Terry C. Orton, Catherine M. Nolan, Heather K. Evans, Robert A. Waterland
Publikováno v:
The American Journal of Pathology. 162:321-328
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and T cell- mediated immunity. M6P/IGF2R is an imprinted gen
Publikováno v:
Genome Research. 10:1711-1718
The evolution of genomic imprinting in mammals occurred more than 100 million years ago, and resulted in the formation of genes that are functionally haploid because of parent-of-origin–dependent expression. Despite ample evidence from studies in a
Publikováno v:
European Journal of Biochemistry. 267:5421-5426
We show here the identity of Alamar Blue as resazurin. The 'resazurin reduction test' has been used for about 50 years to monitor bacterial and yeast contamination of milk, and also for assessing semen quality. Resazurin (blue and nonfluorescent) is
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 14:65-72
The molecular basis of how rodent nongenotoxic hepatocarcinogens such as phenobarbitone cause liver-tumor formation is poorly understood. An early effect of phenobarbitone exposure is to induce hepatocyte proliferation transiently, and there is evide
Publikováno v:
Carcinogenesis. 17:973-981
Liver enlargement is a common feature of non-genotoxic rodent hepatocarcinogens administered at high doses. In the present study, the expression of growth factors and growth factor receptors was investigated in the C57BL/1OJ mouse during liver enlarg