Výsledky vyhledávání - "Terry A Jacot"

Akademický článek

Rapid measures of user's adherence to vaginal drug products using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and multivariate discriminant techniques.

Autor: Oluwatosin E Adedipe, Terry A Jacot, Andrea R Thurman, Gustavo F Doncel, Meredith R Clark

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0197906 (2018)

BACKGROUND:The topical HIV prevention (microbicides) field is in acute need of a method to rapidly and objectively measure adherence to product use in clinical trials. Infrared (IR) spectroscopy has been used in many pharmaceutical and forensic appli

Externí odkaz: https://doaj.org/article/4d6aef2709c34b6b97252e6812d4186e

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Development of a composite measure of product adherence, protocol compliance, and semen exposure using DNA and protein biomarkers for topical HIV prevention studies.

Autor: Terry A Jacot, Ashley Nelson, Andrea Thurman, Angela D M Kashuba, David F Archer, Gustavo F Doncel

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114368 (2014)

Poor and inconsistent use of study products has hindered clinical HIV prevention studies. It is important to be able to monitor product adherence and protocol compliance in order to determine microbicide efficacy and safety more accurately. Current m

Externí odkaz: https://doaj.org/article/bb4acd68a46948c1a852819e054a5b97

Zobrazit plný text záznamu

Akademický článek

Detection and quantification of antiviral drug tenofovir using silver nanoparticles and surface enhanced Raman spectroscopy (SERS) with spatially resolved hotspot selection

Autor: Marguerite R. Butler, Jana Hrncirova, Terry A. Jacot, Sucharita Dutta, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper

Publikováno v: Frontiers in Nanotechnology, Vol 5 (2023)

This study introduces a convenient and ultra-sensitive method of detection and quantification of the antiviral drug, tenofovir (TFV), by surface-enhanced Raman spectroscopy (SERS). Novel spatially resolved instrumentation for spectral acquisition and

Externí odkaz: https://doaj.org/article/c7ad13af0b5c409b8266714001a08d0f

Zobrazit plný text záznamu

Akademický článek

Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya

Publikováno v: Frontiers in Reproductive Health, Vol 5 (2023)

IntroductionGlobally, many young women face the overlapping burden of HIV infection and unintended pregnancy. Protection against both may benefit from safe and effective multipurpose prevention technologies.MethodsHealthy women ages 18–34 years, no

Externí odkaz: https://doaj.org/article/5c0798227a72433685820cec538beb32

Zobrazit plný text záznamu

Akademický článek

Application of a composite measure of product adherence, protocol compliance, and semen exposure to a phase III microbicide HIV prevention trial

Autor: Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Tina Cunningham, Susan Ju, Jill L. Schwartz, Sinead Delany-Moretlwe, Andrea R. Thurman, Gustavo F. Doncel

Publikováno v: Translational Medicine Communications, Vol 6, Iss 1, Pp 1-9 (2021)

Abstract Background Strict adherence to antiretroviral-based microbicide use is important for effective HIV prevention. We previously developed a composite measure of product adherence, protocol compliance, and semen exposure for determining vaginal

Externí odkaz: https://doaj.org/article/829fb4703ac84b359d27d1df33dac805

Zobrazit plný text záznamu

Akademický článek

The use of objective adherence measures targeting four placebo microbicide delivery forms in the Quatro Clinical Crossover Study

Autor: Terry A. Jacot, Oluwatosin E. Adedipe, Susan Godbout, Abby G. Peele, Jill L. Schwartz, Susan Ju, Tina D. Cunningham, Elizabeth Montgomery, Ariane van derStraten, Mags Beksinska, Jenni Smit, Nyaradzo Mgodi, Andrea R. Thurman, Meredith R. Clark, Gustavo F. Doncel

Publikováno v: Clinical and Translational Discovery, Vol 1, Iss 1, Pp n/a-n/a (2021)

Abstract Background Adherence to topical microbicides for HIV prevention has been a challenge for women using them and those developing novel products. The Quatro Clinical Crossover Study investigated user preference and acceptability of four differe

Externí odkaz: https://doaj.org/article/130b6d02e19540adb64af668d642be9d

Zobrazit plný text záznamu

Drospirenone Effects on the Plasminogen Activator System in Immortalized Human Endometrial Endothelial Cells

Autor: Reem Sabouni, David F. Archer, Terry A. Jacot

Publikováno v: Reproductive Sciences. 28:1974-1980

Drospirenone (DRSP) is a fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR) in addition to uniquely interacting to the mineralocorticoid receptor (MR). The known effects of DRSP via the mineraloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::662301bbc928a52eb5b47bc5ff53109d
https://doi.org/10.1007/s43032-020-00433-x

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání