Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Terrone L. Rosenberry"'
Autor:
Fidha Nazreen Kunnath Muhammedkutty, Ramesh Prasad, Yuan Gao, Tarunya Rao Sudarshan, Alicia S. Robang, Jens O. Watzlawik, Terrone L. Rosenberry, Anant K. Paravastu, Huan-Xiang Zhou
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Amyloid beta (Aβ) aggregation is a slow process without seeding or assisted nucleation. Sodium dodecyl sulfate (SDS) micelles stabilize Aβ42 small oligomers (in the dimer to tetramer range); subsequent SDS removal leads to a 150-kD Aβ42 o
Externí odkaz:
https://doaj.org/article/cdbaac7f83d642a1869fa7beaa06d63f
Publikováno v:
Molecules, Vol 27, Iss 24, p 8804 (2022)
The brains of Alzheimer’s disease (AD) patients contain numerous amyloid plaques that are diagnostic of the disease. The plaques are primarily composed of the amyloidogenic peptides proteins Aβ40 and Aβ42, which are derived by the processing of t
Externí odkaz:
https://doaj.org/article/30271da97bbd43a2b1522c7508c6e8f1
Autor:
Caitlin N. Suire, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K. Brizuela, Paul Saftig, Dennis W. Dickson, Terrone L. Rosenberry, Malcolm A. Leissring
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)
Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD). Here, we sought to exami
Externí odkaz:
https://doaj.org/article/1821d16775a34e1e99653b8ba4980045
Autor:
Terrone L. Rosenberry
Publikováno v:
Molecules, Vol 25, Iss 19, p 4412 (2020)
Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant
Externí odkaz:
https://doaj.org/article/1afc7f1f482e45dd99c6ed201b07dd29
Publikováno v:
Molecules, Vol 25, Iss 5, p 1198 (2020)
Over recent decades, crystallographic software for data processing and structure refinement has improved dramatically, resulting in more accurate and detailed crystal structures. It is, therefore, sometimes valuable to have a second look at “old”
Externí odkaz:
https://doaj.org/article/2b96674549cf4f958a9ba96e61c7ed12
Autor:
Terrone L. Rosenberry, Xavier Brazzolotto, Ian R. Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nachon
Publikováno v:
Molecules, Vol 22, Iss 12, p 2098 (2017)
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Although closely related, these enzymes display very different substrat
Externí odkaz:
https://doaj.org/article/8352544fa6454ca8a762d800956c202b
Autor:
Yuan Gao, Ramesh Prasad, Peter S. Randolph, Jens O. Watzlawik, Alicia S. Robang, Cong Guo, Scott M. Stagg, Huan-Xiang Zhou, Terrone L. Rosenberry, Anant K. Paravastu
Previous reports revealed that sodium dodecyl sulfate near its critical micelle concentration can drive the assembly of Aβ42 along an oligomeric pathway. This pathway produces a 150 kDa peptide oligomer (approximately 32 peptide molecules or protome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bf4eb89d7245c51e1f36de04d779e83
https://doi.org/10.1101/2022.12.06.519347
https://doi.org/10.1101/2022.12.06.519347
Autor:
SO Abdul-Hay, Caitlin N. Suire, Dennis W. Dickson, Monica K Brizuela, Dongcheul Kang, Tomoko Sahara, Malcolm A. Leissring, Terrone L. Rosenberry, Paul Saftig
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD). Here, we sought to examine the co
Autor:
Ying Wang, Santanu Bhattacharya, Ramcharan Singh Angom, Pritam Das, Jens O. Watzlawik, Enfeng Wang, Terrone L. Rosenberry, Krishnendu Pal, Debabrata Mukhopadhyay
Publikováno v:
The FASEB Journal. 33:4626-4637
Aggregated amyloid β (Aβ) peptides in the Alzheimer’s disease (AD) brain are hypothesized to trigger several downstream pathologies, including cerebrovascular dysfunction. Previous studies have shown that Aβ peptides can have antiangiogenic prop
Autor:
Joseph L. Johnson, Kunisi S. Venkatasubban, Jamie L. Thomas, Terrone L. Rosenberry, Abdul H. Fauq, Bernadette Cusack
Publikováno v:
Archives of Biochemistry and Biophysics. 655:67-74
Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by