Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Terri S. Purchase"'
Autor:
N. Suman-Chauhan, Louise Webdale, Bharat K. Trivedi, Terri S. Purchase, Bruce D. Roth, Bradley Dean Tait, Michael W. Wilson, C.E. Augelli-Szafran
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2009-2014
Due to the interesting pharmacological activity observed for CI-988, a potent and selective CCK-B receptor antagonist, we have continued to study the SAR of this antagonist. This particular study examines the importance of the indole moiety for bindi
Autor:
R. L. Stanfield, K. L. Hamelehle, Brian R. Krause, Bharat K. Trivedi, A. D. Essenburg, Ann Holmes, Terri S. Purchase, MaryKay Shaw Hes
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:739-747
Our continued interest in developing novel, potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, and our discovery of several active series of disubstituted urea ACAT inhibitors, have led us to investigate a series of trisubstituted ureas t
Autor:
Martyn Clive Pritchard, Bruce D. Roth, N. Suman-Chauhan, Daniel F. Ortwine, C.E. Augelli-Szafran, David R. Hill, David Christopher Horwell, Clare O. Kneen, Bharat K. Trivedi, Louise Webdale, Terri S. Purchase
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:1733-1745
A study of structure-activity relationships of a series of ‘dipeptoid’ CCK-B receptor antagonists was performed in which variations of the phenyl ring were examined while the [(2-adamantyloxy)carbonyl]-α-methyl-R)-tryptophan moiety of the potent
Autor:
R. L. Stanfield, Bharat K. Trivedi, Brian R. Krause, A. D. Essenburg, K. L. Hamelehle, Terri S. Purchase, Ann Holmes, MaryKay Shaw Hes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2229-2234
A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylureas has been synthesized and evaluated as potential ACAT inhibitors. Most of these analogs are potent inhibitors of ACAT in vitro and lower plasma cholesterol i
Autor:
Terri S. Purchase, Brian R. Krause, M. K. Shaw Hes, R. L. Stanfield, A. D. Essenburg, K. L. Hamelehle, Bharat K. Trivedi, Ann Holmes
Publikováno v:
ChemInform. 27
Autor:
N. Suman-Chauhan, Bradley Dean Tait, Bharat K. Trivedi, Bruce D. Roth, Terri S. Purchase, Michael W. Wilson, C.E. Augelli-Szafran, Louise Webdale
Publikováno v:
ChemInform. 28
Due to the interesting pharmacological activity observed for CI-988, a potent and selective CCK-B receptor antagonist, we have continued to study the SAR of this antagonist. This particular study examines the importance of the indole moiety for bindi
Autor:
A. D. Essenburg, Terri S. Purchase, Ann Holmes, R. L. Stanfield, Brian R. Krause, Corinne E. Augelli-Szafran, R. F. Bousley, K. L. Hamelehle, Bharat K. Trivedi
Publikováno v:
Journal of medicinal chemistry. 37(11)
We recently described our initial structure-activity relationship (SAR) studies on a series of N-phenyl-N'-aralkyl- and N-phenyl-N'-(1-phenylcycloalkyl)ureas as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). From this series of analogs,