Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Terri Mitchard"'
Publikováno v:
Toxicology and Applied Pharmacology. 329:85-95
Naloxegol is an opioid antagonist which has been developed for the treatment of patients with opioid induced constipation. In the nonclinical safety program naloxegol was shown to have a very benign toxicity profile. In the rat, but not the mouse, 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01b39b65154a068a099cef6e6c2701f
https://doi.org/10.1016/j.taap.2017.05.032
https://doi.org/10.1016/j.taap.2017.05.032
Publikováno v:
Reproductive Toxicology. 67:140-145
The effects on fetal weights and maternal health of taking 32 μL blood microsamples at the end of organogenesis in a mouse embryofetal development (EFD) study design was investigated with the aim of reducing satellite animal usage. The effects of wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078d7e9c2348f87ac4bc7e19a988d75b
https://doi.org/10.1016/j.reprotox.2016.12.006
https://doi.org/10.1016/j.reprotox.2016.12.006
Publikováno v:
Toxicologic Pathology. 44:866-873
Epiphyseal growth plate dysplasia (chondrodysplasia) might be considered as the pathognomonic feature of antiangiogenic treatment in preclinical species as it is reliably and dose-responsively induced in rodents and monkeys with vascular endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddca9da1fdc9f656e0438276850d8ab
https://doi.org/10.1177/0192623316646483
https://doi.org/10.1177/0192623316646483
Autor:
Stephanie Klein, Terri Mitchard
Publikováno v:
Experimental and Toxicologic Pathology. 68:143-147
A study using vehicle administration in 104 female rats investigated reproductive aging in Han Wistar rats as a useful tool to interprete carcinogenicity studies where hormonal patterns are perturbated. From 16 weeks of age oestrous cycles were monit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d78071901258efd9d46213fc518a676
https://doi.org/10.1016/j.etp.2015.11.006
https://doi.org/10.1016/j.etp.2015.11.006
Autor:
Jane Stewart, Terri Mitchard
Publikováno v:
Reproductive Toxicology. 45:39-44
There is a "chondrodystrophy" syndrome in the Han Wistar rat fetus that manifests as characteristic skeletal abnormalities such as bent and/or short long bones, and is classified as permanent detrimental abnormalities (major malformations). This pilo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c99dfa56d1262c7a46091c38a3e3a4
https://doi.org/10.1016/j.reprotox.2014.01.001
https://doi.org/10.1016/j.reprotox.2014.01.001
Autor:
Terri Mitchard, Jane Stewart
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:152-161
Glucokinase activators (GKAs), such as AZD1656, are designed as antihyperglycemic agents for diabetics and can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies. Genetically modified heterozygous GK knockout (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7936de049039e2fd55e4be3c81a1e4ad
https://doi.org/10.1002/bdrb.21102
https://doi.org/10.1002/bdrb.21102
Autor:
Sue Bickerton, Michelle Coulson, Jane Stewart, Catherine J. Betts, Jayne Harris, Terri Mitchard
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 98:82-90
BACKGROUND: This study examined the correlation between Inhibin B and testicular pathology. METHODS: Male Han Wistar rats (approximately 10 weeks old) were administered either vehicle or an endothelin receptor antagonist (ET-An) orally for 28 days or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10aa0b8b195c2154d73b9e8635795b6
https://doi.org/10.1002/bdrb.21044
https://doi.org/10.1002/bdrb.21044
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 95:410-420
An outcome and statistical review of male reproductive performance assessed by including a mating phase within 6-month general toxicity studies in the Han Wistar rat was undertaken. The basic study design was 16-20 animals per group dosed for approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6a6a2e515936f9cb1992c9eaa3c914
https://doi.org/10.1002/bdrb.21030
https://doi.org/10.1002/bdrb.21030
Autor:
Jennifer C. Sasaki, Monica Seger, James H. Kim, Louise Parks Saldutti, Robert E. Chapin, Brian P. Enright, Keith Jarvi, David Gregory Hall, Mary L. Hixon, Jeffrey S. Moffit, William J. Breslin, Terri Mitchard
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92:511-525
BACKGROUND: Testicular toxicity (TT) is a sporadic and challenging issue in pharmaceutical drug development. Efforts to develop TT screening assays or biomarkers have been overshadowed by consortium efforts to predict drug-induced toxicities such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc543787a7276fd3f89d203d2dd4c7f
https://doi.org/10.1002/bdrb.20338
https://doi.org/10.1002/bdrb.20338
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 104(3)
In the pharmaceutic ICH S5(R2) guidelines for reproductive toxicity testing, a premating dose duration of 14 days is considered sufficient for assessment of male fertility for compounds that are not testicular toxicants. A novel α7 subtype of nicoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4319406a43e56ada4558487fff4615bc
https://pubmed.ncbi.nlm.nih.gov/26194980
https://pubmed.ncbi.nlm.nih.gov/26194980