Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Terri F. Swearengin"'
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ortho-toluidine blood protein adducts: HPLC analysis with fluorescence detection after a single dose in the adult male rat*1
Autor: Terri F. Swearengin, Kenneth L. Cheever, D. Gayle DeBord, Angela D. Booth-Jones
Publikováno v: Fundamental and Applied Toxicology. 18:522-531
Hemoglobin (Hb) and albumin (Alb) adducts of the suspect human carcinogen ortho-toluidine (OT) were quantified in blood samples collected from rats after a single i.p. injection. Mild alkaline hydrolysis of Hb adducted with [14C]OT followed by extrac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fb091191a5a058735f4663e8fff5c23
https://doi.org/10.1016/0272-0590(92)90111-t
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4
4,4?Methylene-bis(2-chloroaniline) (MOCA): Comparison of macromolecular adduct formation after oral or dermal administration in the rat*1
Autor: Kenneth L. Cheever, Russell E. Savage, Donald E. Richards, Terri F. Swearengin, Walter W. Weigel, D. Gayle DeBord, Karen B. Begley
Publikováno v: Fundamental and Applied Toxicology. 14:273-283
The macromolecular binding of 4,4'-methylenebis(2-chloroaniline) (MOCA), a suspect human carcinogen, was studied in the adult male Sprague-Dawley rat after both oral and dermal administration. Rats were euthanized 1, 3, 7, 10, 14, and 29 days after a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b7ee6467b3cca890d4139d96393e0e0
https://doi.org/10.1016/0272-0590(90)90207-z
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6
Determination of 4,4'-methylene-bis(2-chloroaniline)-DNA adduct formation in rat liver and human uroepithelial cells by the 32P postlabeling assay
Autor: Terri F. Swearengin, Thomas M. Reid, Dwight Werren, Kenneth L. Cheever, Russell E. Savage, D. Gayle DeBord
Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 30(1)
The probable human carcinogen 4,4'-methylene-bis(2-chloroaniline) (MOCA) was utilized to develop biomarkers of exposure to occupational carcinogens. The 32P postlabeling assay, utilizing the nuclease P1 enhancement procedure, was used to evaluate MOC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1170de2a2a10767ac0ce7b8745754de8
https://pubmed.ncbi.nlm.nih.gov/8812257
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7
Binding characteristics of ortho-toluidine to rat hemoglobin and albumin
Autor: Terri F. Swearengin, Kenneth L. Cheever, D.G DeBord, AD Booth-Jones, LA Wissinger
Publikováno v: Archives of toxicology. 66(4)
The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b4f212eb1164ddeca277b0dadbbd9d
https://pubmed.ncbi.nlm.nih.gov/1514920
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8
4,4'-Methylenebis(2-chloroaniline) (MOCA): the effect of multiple oral administration, route, and phenobarbital induction on macromolecular adduct formation in the rat
Autor: Kenneth L. Cheever, D. Gayle DeBord, Terri F. Swearengin
Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 16(1)
The effect of multiple oral administration of MOCA, a suspect human carcinogen, was studied in the adult male rat. As many as 28 consecutive daily doses of [14C]MOCA at 28.1 mumol/kg body wt (5 microCi/day) were administered and rats were euthanized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069bcc93c143dc0e693565505301c05d
https://pubmed.ncbi.nlm.nih.gov/2019352
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