Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Terrence L, Geiger"'
Autor:
Aimee C. Talleur, Amr Qudeimat, Jean-Yves Métais, Deanna Langfitt, Ewelina Mamcarz, Jeremy Chase Crawford, Sujuan Huang, Cheng Cheng, Caitlin Hurley, Renee Madden, Akshay Sharma, Ali Suliman, Ashok Srinivasan, M. Paulina Velasquez, Esther A. Obeng, Catherine Willis, Salem Akel, Seth E. Karol, Hiroto Inaba, Allison Bragg, Wenting Zheng, Sheng M. Zhou, Sarah Schell, MaCal Tuggle-Brown, David Cullins, Sagar L Patil, Ying Li, Paul G. Thomas, Caitlin Zebley, Benjamin Youngblood, Ching-Hon Pui, Timothy Lockey, Terrence L. Geiger, Michael M. Meagher, Brandon M. Triplett, Stephen Gottschalk
Publikováno v:
Blood Advances. 6:5737-5749
T cells expressing CD19-specific chimeric antigen receptors (CD19-CARs) have potent antileukemia activity in pediatric and adult patients with relapsed and/or refractory B-cell acute lymphoblastic leukemia (B-ALL). However, not all patients achieve a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7608cb41fbd9779a4847da9b6c1d9a6d
https://doi.org/10.1182/bloodadvances.2021006293
https://doi.org/10.1182/bloodadvances.2021006293
Autor:
Ti-Cheng Chang, Robert A. Carter, Yongjin Li, Yuxin Li, Hong Wang, Michael N. Edmonson, Xiang Chen, Paula Arnold, Terrence L. Geiger, Gang Wu, Junmin Peng, Michael Dyer, James R. Downing, Douglas R. Green, Paul G. Thomas, Jinghui Zhang
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-12 (2017)
Abstract Background Neoepitopes derived from tumor-specific somatic mutations are promising targets for immunotherapy in childhood cancers. However, the potential for such therapies in targeting these epitopes remains uncertain due to a lack of knowl
Externí odkaz:
https://doaj.org/article/867cf2f09dff4b2da29143808be434ba
Publikováno v:
Curr Opin Biotechnol
T cells shape immune responses in cancer, autoimmunity and infection, in which CD4(+) T helper (Th) and CD8(+) T cells mediate effector responses that are suppressed by regulatory T (T(reg)) cells. The balance between effector T cell and T(reg) cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eec33b97ffd834881920e7f86cfbdbe
https://doi.org/10.1016/j.copbio.2021.02.003
https://doi.org/10.1016/j.copbio.2021.02.003
Autor:
Lori Sweat, Maria Gann, Terrence L. Geiger, Deqing Pei, Yan Zheng, Missy Ryan, Cheng Cheng, Mark A. Mestemacher
Publikováno v:
Transfusion. 61:744-753
BACKGROUND Pediatric hematology-oncology patients require frequent platelet transfusions to manage chemotherapy-induced thrombocytopenia, and allergic transfusion reactions (ATRs) are common. Risk for platelet-associated ATRs can result from recipien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15acbadc874bc08033d94c9801a7f87
https://doi.org/10.1111/trf.16221
https://doi.org/10.1111/trf.16221
Publikováno v:
Haematologica, Vol 100, Iss 3 (2015)
Current therapies for acute myeloid leukemia are associated with high failure and relapse rates. Adoptive immunotherapies, which have shown promise in the treatment of hematologic malignancies, have the potential to target acute myeloid leukemia thro
Externí odkaz:
https://doaj.org/article/8d5c69e2b43049f1a592f3248fec77da
Autor:
Caitlin C. Zebley, Wenting Zheng, Terrence L. Geiger, Jayadev Mavuluri, Benjamin Youngblood, Yong-Dong Wang, Lindsay L. Jones, Lingyun Long, Yiping Fan, Hongbo Chi, Jun Wei, Yogesh Dhungana
Publikováno v:
Blood
Chimeric antigen receptor (CAR)–T-cell therapeutic efficacy is associated with long-term T-cell persistence and acquisition of memory. Memory-subset formation requires T-cell factor 1 (TCF-1), a master transcription factor for which few regulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca502bac36815990017d6ae3081fae2
https://pubmed.ncbi.nlm.nih.gov/35323877
https://pubmed.ncbi.nlm.nih.gov/35323877
Publikováno v:
The Journal of Immunology. 201:2934-2946
IL-6 is a critical driver of acute and chronic inflammation and has been reported to act as a T cell survival factor. The influence of IL-6 on T cell homeostasis is not well resolved. We demonstrate that IL-6 signaling drives T cell expansion under i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736495624e3426689578ec1595fb7c9f
https://doi.org/10.4049/jimmunol.1800016
https://doi.org/10.4049/jimmunol.1800016
Autor:
Anusha Sunkara, Sima Jeha, Akshay Sharma, Terrence L. Geiger, Brandon M. Triplett, Guolian Kang, Shane J Cross, Hiroto Inaba
Publikováno v:
Journal of Pediatric Hematology/Oncology. 40:e479-e485
Recurrent/refractory hematologic malignancies have a poor prognosis, and there is a need for novel treatment regimens that can be tolerated by this heavily pretreated patient group. Clofarabine has antileukemic activity with an acceptable toxicity pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6a21421f845f4ba73efb63ebc1ab0d
https://doi.org/10.1097/mph.0000000000001222
https://doi.org/10.1097/mph.0000000000001222
Autor:
Terrence L. Geiger, Hossam A. Abdelsamed, Ben Youngblood, Rajshekhar Alli, Carol E. O’Hear, Jacob Halum Basham, Wenting Zheng, Lance E. Palmer, Lindsay L. Jones
Publikováno v:
Leukemia. 32:1157-1167
In vivo persistence of chimeric antigen receptor (CAR)-modified T cells correlates with therapeutic efficacy, yet CAR-specific factors that support persistence are not well resolved. Using a CD33-specific CAR in an acute myeloid leukemia (AML) model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa10d9770eb0ca375d0915d8fd302e66
https://doi.org/10.1038/s41375-017-0008-6
https://doi.org/10.1038/s41375-017-0008-6
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18027 (2011)
Enhancing the affinity of therapeutic T cell receptors (TCR) without altering their specificity is a significant challenge for adoptive immunotherapy. Current efforts have primarily relied on empirical approaches. Here, we used structural analyses to
Externí odkaz:
https://doaj.org/article/efb41d259f3f4f2a84d555222be9ea0f