Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Terrence L, Fisher"'
Autor:
Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology. Molecular pathways that trigger reactive astrocyte
Externí odkaz:
https://doaj.org/article/01b6646059f34cdbb38b673af2c1aec2
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Analysis and statistics for tumor growth, survival and CR: Immunohistochemistry methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7f9c6525bdc53d65ad79007e8f1a18
https://doi.org/10.1158/2326-6066.22538348
https://doi.org/10.1158/2326-6066.22538348
Autor:
Maurice Zauderer, Ernest S. Smith, Christine Reilly, Chad A. Cornelius, Laurie A. Winter, Terrence L. Fisher, John E. Leonard
Supplemental Methods: Nonclinical Safety Evaluation of VX15/2503; a Humanized IgG4 Anti-SEMA4D Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3774c01cfea91b9668675fc49e3ef1fd
https://doi.org/10.1158/1535-7163.22499830.v1
https://doi.org/10.1158/1535-7163.22499830.v1
Autor:
Maurice Zauderer, Ernest S. Smith, Christine Reilly, Chad A. Cornelius, Laurie A. Winter, Terrence L. Fisher, John E. Leonard
The humanized IgG4 monoclonal antibody VX15/2503 bound with 1 to 5 nmol/L affinity to purified recombinant semaphorin 4D (SEMA4D; CD100) produced using murine, rat, cynomolgus macaque, and human sequences. The affinity for native SEMA4D expressed on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b623f950c834e4e92e057a195de4b1dc
https://doi.org/10.1158/1535-7163.c.6536278
https://doi.org/10.1158/1535-7163.c.6536278
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Supplementary Figure S1: SEMA4D and PLXNB1 are highly expressed in human cancer. Supplementary Figure S2: SEMA4D gradient at tumor leading edge. Supplementary Figure S3: Tumor volumes of mice selected for immune cell characterization and functional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3e741fdd3c1064046f9b7911f212d3
https://doi.org/10.1158/2326-6066.22538351.v1
https://doi.org/10.1158/2326-6066.22538351.v1
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are broadly expressed in murine and human tumors, and their expression has been shown to correlate with invasive disease in several human tumors. SEMA4D normally functions to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f46dcb34992473e0cbb195d9773fa727
https://doi.org/10.1158/2326-6066.c.6548750.v1
https://doi.org/10.1158/2326-6066.c.6548750.v1
Autor:
Ramesh K. Ramanathan, Maurice Zauderer, Anthony W. Tolcher, Lisa Blaydorn, Danielle Mutz, Robert B. Parker, Christine Reilly, Laurie A. Winter, Terrence L. Fisher, Jasgit C. Sachdev, Drew Warren Rasco, John E. Leonard, Glen J. Weiss, Amita Patnaik
This Supplementary Methods section provides details for assays that allowed elucidation of the pharmacokinetic and pharmacodynamic results described in the Results and Discussion sections of the article. These supplemental methods descriptions are to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3066fa1e6be8e33472309f09694ccdf
https://doi.org/10.1158/1078-0432.22461908.v1
https://doi.org/10.1158/1078-0432.22461908.v1
Autor:
Ramesh K. Ramanathan, Maurice Zauderer, Anthony W. Tolcher, Lisa Blaydorn, Danielle Mutz, Robert B. Parker, Christine Reilly, Laurie A. Winter, Terrence L. Fisher, Jasgit C. Sachdev, Drew Warren Rasco, John E. Leonard, Glen J. Weiss, Amita Patnaik
Purpose: Study objectives included evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of VX15/2503 in advanced solid tumor patients.Experimental Design: Weekly i.v. doses were administered on a 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03953d323fbe1ccdabd42ebdf048f363
https://doi.org/10.1158/1078-0432.c.6524393
https://doi.org/10.1158/1078-0432.c.6524393
Autor:
Maurice Zauderer, Jonathan W. Goldman, Rachel E. Sanborn, Aaron S. Mansfield, Yanyan Lou, Nagashree Seetharamu, Alexander I. Spira, Nashat Y. Gabrail, Ramaswamy Govindan, Megan A. Baumgart, Joseph T. Beck, Kevin M. Chin, Andreas Schröder, Vikas Mishra, Ernest Smith, Crystal L. Mallow, Desa Rae E. Pastore, John E. Leonard, Elizabeth E. Evans, Terrence L. Fisher, Michael R. Shafique
Correlative biomarker analysis: 4A, Shift in balance of tumoral myeloid cells correlates with response. 4B, Baseline circulating AMC and ANC correlate with PFS 4C, High baseline circulating AMC:ALC is associated with disease progression and resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc177fe3c052bf46df5128bae056d45
https://doi.org/10.1158/1078-0432.22480740
https://doi.org/10.1158/1078-0432.22480740
Autor:
Ramesh K. Ramanathan, Maurice Zauderer, Anthony W. Tolcher, Lisa Blaydorn, Danielle Mutz, Robert B. Parker, Christine Reilly, Laurie A. Winter, Terrence L. Fisher, Jasgit C. Sachdev, Drew Warren Rasco, John E. Leonard, Glen J. Weiss, Amita Patnaik
This supplementary information file contains the Figure Legend for the Supplementary Figure S1. This figure legend and Supplementary Figure Fig S1 are intended for publication with the manuscript; Fig S1 shows the effect of VX15/2503 administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e49853004a18ae90b25186209ab268c
https://doi.org/10.1158/1078-0432.22461911.v1
https://doi.org/10.1158/1078-0432.22461911.v1