Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Terrence J. Gillespie"'
Publikováno v:
Regulatory Peptides. 98:19-25
Insulin-like growth factors (IFGs), IGF-I and IGF-II, present in mammalian milk, play an important role during gastrointestinal tract development. In this study we identified and localized the activities of the common intestinal proteolytic enzymes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652c29e65eb8c2cdbc805b4f61b03614
https://doi.org/10.1016/s0167-0115(00)00216-0
https://doi.org/10.1016/s0167-0115(00)00216-0
Autor:
Tp. Davis, Victor J. Hruby, Terrence J. Gillespie, Aleksandra Misicka, Sarah A. Williams, Xinhua Qian, Guo-Qiao Li, F Porreca, Robin Polt, Lajos Szabo, David F. O'Brien, Hubert Bartosz, Henry I. Yamamura, Dinesh V. Patel, Andrzej W. Lipkowski, G. Gregg Bonner
Publikováno v:
Analgesia. 1:469-472
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ccbe4c31d4f5aebc7c5287d9d9b9109
https://doi.org/10.3727/107156995819562961
https://doi.org/10.3727/107156995819562961
Publikováno v:
Life Sciences. 51:2097-2106
A specific enzyme assay for aminopeptidase M (APM) activity on rat brain membranes has been developed through selective use of enzyme inhibitors. Amastatin was the most potent inhibitor (amastatin > actinonin > MDL73347 > bestatin) for purified porci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274749f385674e101984a2f6dc595ad3
https://doi.org/10.1016/0024-3205(92)90161-h
https://doi.org/10.1016/0024-3205(92)90161-h
Publikováno v:
Peptides. 22(12)
Peptides have the potential to be potent pharmaceutical agents for the treatment of many central nervous system derived maladies. Unfortunately peptides are generally water-soluble compounds that will not enter the central nervous system, via passive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13265a3c7b2b439240656868e15f5e23
https://pubmed.ncbi.nlm.nih.gov/11786210
https://pubmed.ncbi.nlm.nih.gov/11786210
Autor:
Victor J. Hruby, C.L Gentry, H.B Bechowski, Richard D. Egleton, Terrence J. Gillespie, Thomas P. Davis, Thomas J. Abbruscato
Publikováno v:
Peptides. 20(10)
The utility of a drug depends on its ability to reach appropriate receptors at the target tissue and remain metabolically stable to produce the desired effect. To improve central nervous system entry of the opioid analgesic [ d -Pen 2 , l -Pen 5 , Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9aa2159cf2a8a1cf1e3e81801c35cb
https://pubmed.ncbi.nlm.nih.gov/10573295
https://pubmed.ncbi.nlm.nih.gov/10573295
Autor:
Frank Porreca, Terrence J. Gillespie, David F. O'Brien, Andrzej W. Lipkowski, Xiaoyun Zhu, Victor J. Hruby, Li Xiang, Thomas P. Davis, Irene A. De Leon, Bih-Show Lou, Marek Romanowski, Peg Davis, W. Haq, Robert Hughes, Henry I. Yamamura, Guigen Li, Aleksandra Misicka
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(5)
Modifications of 4,4′ residues of Biphalin have resulted in greater binding selectivity and biological potency for the μ opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a β-branc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3180bae9318eb43fd695f4f98bb466e7
https://pubmed.ncbi.nlm.nih.gov/9871617
https://pubmed.ncbi.nlm.nih.gov/9871617
Publikováno v:
Peptides. 16(7)
Eight analogues of DYN A(1-11)-NH2 incorporating the nonhydrolyzable psi [CH2-NH] peptide bond surrogate were tested for their in vitro enzymatic stability in mouse brain homogenates. Results show that the Leu(5)-Arg6 and to a lesser extent the Arg(7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce21cd2e2f6d7fd9aede564fcf0b6a2b
https://pubmed.ncbi.nlm.nih.gov/8545241
https://pubmed.ncbi.nlm.nih.gov/8545241
Publikováno v:
Journal of neurochemistry. 58(2)
Regional differences in neurotensin metabolism and the peptidases involved were studied using intact, viable rat brain microslices and specific peptidase inhibitors. Regional brain slices (2 mm x 230 microns) prepared from nucleus accumbens, caudate-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf20470a4a7692c754c8e3333bc2cd2
https://pubmed.ncbi.nlm.nih.gov/1729405
https://pubmed.ncbi.nlm.nih.gov/1729405
Autor:
Thomas H. Kramer, Terrence J. Gillespie, Gifford L. Hoyer, J E Shook, Kumiko N. Hawkins, Thomas F. Burks, Henry I. Yamamura, Thomas P. Davis, Peg Davis
Publikováno v:
Gastroenterology. 100(6)
Peptide E is a μ-selective opioid peptide derived from proenkephalin A which contains [Met 5 ]-enkephalin at the amino end and [Leu 5 ]-enkephalin at the carboxyl end. Peptide E is further processed both centrally and peripherally to a [Leu 5 ]-enke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bd3dd87e1f7026ff7517723a60a61e
https://pubmed.ncbi.nlm.nih.gov/1850373
https://pubmed.ncbi.nlm.nih.gov/1850373
Publikováno v:
Gastroenterology. 118:A1067
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9770dc2fb035e20dd52fd52fbf0e8b56
https://doi.org/10.1016/s0016-5085(00)80062-1
https://doi.org/10.1016/s0016-5085(00)80062-1