Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Terrence Hanscom"'
Autor:
Luis M. M. Soares, Terrence Hanscom, Donald E. Selby, Samuel Adjei, Wei Wang, Dariusz Przybylski, John F. Thompson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract There are many applications in which quantitative information about DNA mixtures with different molecular lengths is important. Gene therapy vectors are much longer than can be sequenced individually via short-read NGS. However, vector prepa
Externí odkaz:
https://doaj.org/article/570c2962ec0448799d54758ad8db824e
Autor:
Terrence Hanscom, Mitch McVey
Publikováno v:
Cells, Vol 9, Iss 7, p 1657 (2020)
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of huma
Externí odkaz:
https://doaj.org/article/88f949565f334f4285a82ae39bb3c2c9
Autor:
Terrence Hanscom, Nicholas Woodward, Rebecca Batorsky, Alexander J Brown, Steven A Roberts, Mitch McVey
Publikováno v:
Nucleic Acids Research. 50:7465-7478
Alternative end joining (alt-EJ) mechanisms, such as polymerase theta-mediated end joining, are increasingly recognized as important contributors to inaccurate double-strand break repair. We previously proposed an alt-EJ model whereby short DNA repea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a94eadcc3da94ccea8db92e07fd14c
https://doi.org/10.1093/nar/gkac575
https://doi.org/10.1093/nar/gkac575
Autor:
Jacob M. Miller, Sydney Prange, Huanding Ji, Alesandra R. Rau, Avi Patel, Nadejda L. Butova, Avery Lutter, Helen Chung, Chiara Merigliano, Chetan C. Rawal, Terrence Hanscom, Mitch McVey, Irene Chiolo
Pericentromeric heterochromatin is highly enriched for repetitive sequences prone to aberrant recombination. Previous studies showed that homologous recombination (HR) repair is uniquely regulated in this domain to enable ‘safe’ repair while prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf968c41a360d3e2a4c094341c382ce1
https://doi.org/10.1101/2023.03.03.531058
https://doi.org/10.1101/2023.03.03.531058
Autor:
Jacinthe Gingras, Thia St Martin, Katie Gall, Jennifer Newman, Donald E. Selby, Samuel Adjei, Terrence Hanscom, Jaime Prout, Dariusz S. Przybylski, Alice Zheng, Nancy Avila, Jason Lotterhand, Israel Rivas, Teresa Wright, Omar Francone, Albert Seymour
Publikováno v:
Molecular Genetics and Metabolism. 138:107112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c9aabb9edfff51135b7c1cca25225c
https://doi.org/10.1016/j.ymgme.2022.107112
https://doi.org/10.1016/j.ymgme.2022.107112
Publikováno v:
Methods in enzymology. 601
In this chapter, we describe a method for the recovery and analysis of alternative end-joining (alt-EJ) DNA double-strand break repair junctions following I-SceI cutting in Drosophila melanogaster embryos. Alt-EJ can be defined as a set of Ku70/80 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::650548dd47a664372ddb01ae104bf545
https://pubmed.ncbi.nlm.nih.gov/29523244
https://pubmed.ncbi.nlm.nih.gov/29523244
Publikováno v:
Methods in Enzymology ISBN: 9780128139790
In this chapter, we describe a method for the recovery and analysis of alternative end-joining (alt-EJ) DNA double-strand break repair junctions following I-SceI cutting in Drosophila melanogaster embryos. Alt-EJ can be defined as a set of Ku70/80 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c36a055b6c87f05c90283275cf5f6f08
https://doi.org/10.1016/bs.mie.2017.11.027
https://doi.org/10.1016/bs.mie.2017.11.027