Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Terrence A. Scahill"'
Autor:
Brian J. Stockman, Terrence A. Scahill, Philip S. Burton, Robert A. Conradi, Jay T. Goodwin, James R. Blinn, David A. Kloosterman
Publikováno v:
Biopolymers. 53:396-410
Efficient transport of intact drug (solute) across the intestinal epithelium is typically a requirement for good oral activity. In general, the membrane permeability of a solute is a complex function of its size, lipophilicity, hydrogen bond potentia
Autor:
David A. Kloosterman, L V Goodman, J.D Petke, G Vogeli, Vincent P. Marshall, B Mao, R. A. Poorman, D.J Waldon, S.A Mizsak, M. A. Mitchell, P S Kaytes, E.J Jacobsen, K L Belonga, G. L. Petzold, E.A Powers, Terrence A. Scahill, J.A Gates, S.R Ledbetter, Brian J. Stockman
Publikováno v:
Scopus-Elsevier
Unregulated or overexpressed matrix metalloproteinases (MMPs), including stromelysin, collagenase, and gelatinase. have been implicated in several pathological conditions including arthritis and cancer. Small-molecule MMP inhibitors may have therapeu
Autor:
Terrence A. Scahill, Brian J. Stockman, Anthony W. Yem, Nancy A. Strakalaitis, Martin R. Deibel, David P. Brunner
Publikováno v:
FEBS Letters. 349:79-83
Interleukin-1 receptor antagonist protein (IRAP) is a naturally occurring inhibitor of the interleukin-1 receptor. In contrast to IL-1 beta, IRAP binds to the IL-1 receptor but does not elicit a physiological response. We have determined the solution
Autor:
Stephen A. Mizsak, Sharon A. Nash, Larry T. Bell, Ronald B. Gammill, Terrence A. Scahill, Denis M. Sobieray, William Watt
Publikováno v:
ChemInform. 22
A unique mode of metal hydride reduction of unsaturated ketones is described which proceeds with a high degree of regio- and stereocontrol.
Autor:
J. S. Althaus, Terrence A. Scahill, Jacob Szmuszkovicz, P. F. Von Voigtlander, Wuyi Wang, A. Ghosh, Jeremiah P. Freeman, Stephen A. Mizsak
Publikováno v:
ChemInform. 23
Autor:
Eldon L. Ulrich, Brian J. Stockman, David P. Brunner, Melinda Roy, Terrence A. Scahill, Nancy A. Strakalaitis, Anthony W. Yem, Martin R. Deibel
Publikováno v:
Biochemistry. 31:5237-5245
Interleukin-1 (IL-1) proteins, such as IL-1 beta, play a key role in immune and inflammatory responses. Interaction of these cytokines with the IL-1 receptor induces a variety of biological changes in neurologic, metabolic, hematologic, and endocrino
Autor:
Philip F. VonVoigtlander, A. Ghosh, Stephen A. Mizsak, Jeremiah P. Freeman, Terrence A. Scahill, Wuyi Wang, John S. Althaust, Jacob Szmuszkovicz
Publikováno v:
Tetrahedron. 47:8653-8662
Syntheses of serotonin analogs 2 and 3 are described including a case of retention in the Mitsunobu reaction. An unusual stereoselectivity in a reductive amination sequence is also described. Dopamine and serotonin activity of the eight analogs has b
Autor:
Terrence A. Scahill, Chong Soon Lee, Mark A. Mitchell, Martha A. Warpehoski, Ilse Gebhard, R. C. Kelly, Wicnienski Nancy Anne, Laurence H. Hurley, J. Patrick McGovren
Publikováno v:
Journal of the American Chemical Society. 112:4633-4649
Autor:
Randy M. Jensen, Nanda D. Brahme, Gary L. Petzold, Wendell Wierenga, David H. Swenson, Nicole T. Hatzenbuhler, Terrence A. Scahill
Publikováno v:
Biochemistry. 29:2852-2860
The binding of the antitumor drug CC-1065 has been studied with nuclear magnetic resonance (NMR) spectroscopy. This study involves two parts, the elucidation of the covalent binding site of the drug to DNA and a detailed investigation of the noncoval
Publikováno v:
Tetrahedron Letters. 31:1977-1980
The efficient preparation of an advanced intermediate for the synthesis of Fastigilin-C 2 , via a furan terminated cationic cyclization, is described.