Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Terrell T. Gibbs"'
Publikováno v:
Autism Research. 6:571-583
Autism is a behaviorally defined, neurological disorder with symptom onset before the age of 3. Abnormalities in social-emotional behaviors are a core deficit in autism, and are characterized by impaired reciprocal-social interaction, lack of facial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83774d0dbd6e5a082d7ddbdcb8ea983f
https://doi.org/10.1002/aur.1317
https://doi.org/10.1002/aur.1317
Autor:
David H. Farb, Stella C. Martin, Terrell T. Gibbs, Emmanuel Kostakis, Ming-Kuei Jang, Kyle G. Richards, Shelley J. Russek, Conor C. Smith
Publikováno v:
Molecular Pharmacology. 84:261-274
N-methyl D-aspartate (NMDA) receptors (NMDARs) mediate fast excitatory synaptic transmission and play a critical role in synaptic plasticity associated with learning and memory. NMDAR hypoactivity has been implicated in the pathophysiology of schizop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd9d78a5cc2939290654d76e0e6aef2
https://doi.org/10.1124/mol.113.085696
https://doi.org/10.1124/mol.113.085696
Publikováno v:
Brain Research. 1380:218-228
Individuals with autism display deficits in the social domain including the proper recognition of faces and interpretations of facial expressions. There is an extensive network of brain regions involved in face processing including the fusiform gyrus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd9e8c903e5671a1b179a04bd16adcf
https://doi.org/10.1016/j.brainres.2010.09.021
https://doi.org/10.1016/j.brainres.2010.09.021
Decreased GABAAreceptors and benzodiazepine binding sites in the anterior cingulate cortex in autism
Publikováno v:
Autism Research. 2:205-219
The anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio-emotional behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be80b585d1f4dcf4818bda7b43bcf7ba
https://doi.org/10.1002/aur.88
https://doi.org/10.1002/aur.88
Publikováno v:
Journal of Neurochemistry. 107:510-521
Pregnenolone sulfate (PS) is a neuroactive steroid that directly modulates glutamate and GABAA receptor function, suggesting that it may regulate the balance between excitatory and inhibitory neurotransmission (Farb and Gibbs 1996; Gibbs and Farb 200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a506f0c1606e953c81e1109e8c932a5
https://doi.org/10.1111/j.1471-4159.2008.05627.x
https://doi.org/10.1111/j.1471-4159.2008.05627.x
Autor:
Phil Skolnick, David H. Farb, Zhengming Chen, Terrell T. Gibbs, Philip Krieter, Shelley J. Russek, Gabriel Nowak, Piotr Popik, Martyna Krawczyk, Arnold S. Lippa, Anthony S. Basile, Emmanuel Kostakis, Bernadeta Szewczyk
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 319:1244-1252
Studies using mice with point mutations of GABA(A) receptor alpha subunits suggest that the sedative and anxiolytic properties of 1,4-benzodiazepines are mediated, respectively, by GABA(A) receptors bearing the alpha(1) and alpha(2) subunits. This hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfb3f3fbc1d7a8526d040b7c37381f6
https://doi.org/10.1124/jpet.106.107201
https://doi.org/10.1124/jpet.106.107201
Publikováno v:
Pharmacology Biochemistry and Behavior. 84:555-567
Central nervous system function is critically dependent upon an exquisitely tuned balance between excitatory synaptic transmission, mediated primarily by glutamate, and inhibitory synaptic transmission, mediated primarily by GABA. Modulation of eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4862a318c557f2fd6bff06339aaf77ab
https://doi.org/10.1016/j.pbb.2006.07.031
https://doi.org/10.1016/j.pbb.2006.07.031
Publikováno v:
British Journal of Pharmacology. 145:894-906
Benzodiazepines (BZDs) have been used extensively for more than 40 years because of their high therapeutic index and low toxicity. Although BZDs are understood to act primarily as allosteric modulators of GABA(A) receptors, the mechanism of modulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e918ef44b9fdf5297326fff4f4afd3
https://doi.org/10.1038/sj.bjp.0706251
https://doi.org/10.1038/sj.bjp.0706251
Autor:
Emmanuel Kostakis, Pál Czobor, Shelley J. Russek, Terrell T. Gibbs, Arnold S. Lippa, Sabita Bandyopadhyay, David H. Farb, Maria Clara Gravielle, Bernard Beer, Phil Skolnick, J. Stark
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Benzodiazepines remain widely used for the treatment of anxiety disorders despite prominent, often limiting side effects including sedation, muscle relaxation, and ataxia. A compound producing a robust anxiolytic action comparable to benzodiazepines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13682cbb9a6b926eadb21265cdaea6f8
https://doi.org/10.1073/pnas.0502579102
https://doi.org/10.1073/pnas.0502579102
Autor:
David H. Farb, Ghazaleh Sadri-Vakili, R. C. Pierce, D. W. Johnson, Terrell T. Gibbs, G. C. Janis
Publikováno v:
Journal of Neurochemistry. 86:92-101
Our laboratory has previously shown that the synthetic neuroactive steroid 3α-hydroxy-5β-pregnan-20-one hemisuccinate (3α5βHS) is a negative modulator of NMDA receptors in vitro. Similarly, 3α5βHS exhibits rapid sedative, analgesic, anticonvuls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ca7a13121cec41d9a3c87730c4657e4
https://doi.org/10.1046/j.1471-4159.2003.01814.x
https://doi.org/10.1046/j.1471-4159.2003.01814.x