Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Terrance A Stadheim"'
Autor:
Hussam H Shaheen, Bianka Prinz, Ming-Tang Chen, Tej Pavoor, Song Lin, Nga Rewa Houston-Cummings, Renee Moore, Terrance A Stadheim, Dongxing Zha
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70190 (2013)
State-of-the-art monoclonal antibody (mAb) discovery methods that utilize surface display techniques in prokaryotic and eukaryotic cells require multiple steps of reformatting and switching of hosts to transition from display to expression. This resu
Externí odkaz:
https://doaj.org/article/af2ec7307fe942b5ae16b287fb069375
Autor:
Rebecca Argyros, Stephanie Nelson, Angela Kull, Ming-Tang Chen, Terrance A Stadheim, Bo Jiang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62229 (2013)
Protein O-mannosyltransferases (PMTs) catalyze the initial reaction of protein O-mannosylation by transferring the first mannose unit onto serine and threonine residues of a nascent polypeptide being synthesized in the endoplasmic reticulum (ER). The
Externí odkaz:
https://doaj.org/article/78740d3227374d53b1a517f11fff3229
Autor:
Kerry Routenberg Love, Timothy J Politano, Vasiliki Panagiotou, Bo Jiang, Terrance A Stadheim, J Christopher Love
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37915 (2012)
Biopharmaceuticals represent the fastest growing sector of the global pharmaceutical industry. Cost-efficient production of these biologic drugs requires a robust host organism for generating high titers of protein during fermentation. Understanding
Externí odkaz:
https://doaj.org/article/490b6394310f4cd2b99b61118f104765
Autor:
Michael Meehl, Terrance A. Stadheim
Publikováno v:
Current Opinion in Biotechnology. 30:120-127
The selection of an expression platform for recombinant biopharmaceuticals is often centered upon suitable product titers and critical quality attributes, including post-translational modifications. Although notable differences between microbial, yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27627369f3fc87218a953ba8b8fb23c2
https://doi.org/10.1016/j.copbio.2014.06.007
https://doi.org/10.1016/j.copbio.2014.06.007
Publikováno v:
Journal of Mass Spectrometry. 48:1308-1317
Glycosylation plays a critical role in the in vivo efficacy of both endogenous and recombinant erythropoietin (EPO). Using mass spectrometry, we characterized the N-/O-linked glycosylation of recombinant human EPO (rhEPO) produced in glycoengineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb76e5de9947c5dceeb8c2a28f54262c
https://doi.org/10.1002/jms.3291
https://doi.org/10.1002/jms.3291
Autor:
Juergen H. Nett, Terrance A. Stadheim, Huijuan Li, Min Du, Piotr Bobrowicz, Daniel Hopkins, Nathan J Sharkey, John Bukowski, W. James Cook, Sujatha Gomathinayagam, Irina Burnina, Stephen R. Hamilton, Shaina Schwartz, Stefan Wildt
Publikováno v:
Glycobiology. 23:1192-1203
The methylotrophic yeast, Pichia pastoris, is an important organism used for the production of therapeutic proteins. Previously, we have reported the glycoengineering of this organism to produce human-like N-linked glycans but up to now no one has ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef85cbf2997467f77dbc6ad086fca73c
https://doi.org/10.1093/glycob/cwt056
https://doi.org/10.1093/glycob/cwt056
Autor:
Byung-Kwon, Choi, Shannon, Warburton, Heping, Lin, Rohan, Patel, Istvan, Boldogh, Michael, Meehl, Meehl, Meehl, Marc, d'Anjou, Liza, Pon, Terrance A, Stadheim, Natarajan, Sethuraman
Publikováno v:
Applied Microbiology and Biotechnology. 95:671-682
Yeast is capable of performing posttranslational modifications, such as N- or O-glycosylation. It has been demonstrated that N-glycans play critical biological roles in therapeutic glycoproteins by modulating pharmacokinetics and pharmacodynamics. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9186d6b241d7ea12bfa2c7f6474668d
https://doi.org/10.1007/s00253-012-4067-3
https://doi.org/10.1007/s00253-012-4067-3
Autor:
Sujatha Gomathinayagam, Nathan Sharkey, Peter M. Gray, Adam Nylen, Min Du, Thomas I. Potgieter, Seemab S. Shaikh, Raymond Evers, Terrance A. Stadheim, Robert C. Davidson, Russell B. Lingham, Julie A. DeMartino, Gavin C. Barnard, Daniel Hopkins, Muralidhar R. Mallem, Natarajan Sethuraman, Juergen H. Nett, Victoria Copeland, Thomas O. Linden, Marc d’Anjou, Yan Li, Liming Liu, Teresa Mitchell, Stephen R. Hamilton, Bing Gong, Denise M. Visco, Gail Forrest, Huijuan Li, Stefan Wildt
Publikováno v:
Journal of Biotechnology. 157:198-206
Pichia pastoris is a methylotropic yeast that has gained great importance as an organism for protein expression in recent years. Here, we report the expression of recombinant human erythropoietin (rhEPO) in glycoengineered P. pastoris. We show that g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5a467004a7cc4428d021a502528910
https://doi.org/10.1016/j.jbiotec.2011.11.002
https://doi.org/10.1016/j.jbiotec.2011.11.002
Autor:
Edward R Zartler, Sujatha Gomathinayagam, Carrie L. Anderson, Christian Heiss, Nga Rewa Houston-Cummings, Natarajan Sethuraman, Parastoo Azadi, Erin Giaccone, Youwei Jiang, Richard J Porambo, Fang Li, Huijuan Li, Teresa Mitchell, Terrance A. Stadheim, Dongxing Zha
Publikováno v:
Glycobiology. 21:1606-1615
The N-glycosylation pathway in Pichia pastoris has been humanized by the deletion of genes responsible for fungal-type glycosylation (high mannose) as well as the introduction of heterologous genes capable of forming human-like N-glycosylation. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61669526f3160c1921a0ec01b29262d2
https://doi.org/10.1093/glycob/cwr082
https://doi.org/10.1093/glycob/cwr082
Autor:
Muralidhar R. Mallem, Ningyan Zhang, Hui Wang, Michael Cukan, Hans E. Huber, Irina Burnina, Rohan Patel, Kim Vo, Teresa I. Mitchell, Youwei Jiang, Liming Liu, Fang Li, Nga Rewa Houston Cummings, Byung-Kwon Choi, Terrance A. Stadheim, Dongxing Zha, Calin D. Dumitru, Yuan Li, Yangsi Ou
Publikováno v:
mAbs. 3:289-298
Mammalian cell culture systems are used predominantly for the production of therapeutic monoclonal antibody (mAb) products. A number of alternative platforms, such as Pichia engineered with a humanized N-linked glycosylation pathway, have recently be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d21141909265a58c128c5d0678f037
https://doi.org/10.4161/mabs.3.3.15532
https://doi.org/10.4161/mabs.3.3.15532