Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tero Hallikainen"'
Autor:
Bettina Konte, James T. R. Walters, Dan Rujescu, Sophie E. Legge, Antonio F. Pardiñas, Dan Cohen, Munir Pirmohamed, Jari Tiihonen, Annette M. Hartmann, Jan P. Bogers, Jan van der Weide, Karen van der Weide, Anu Putkonen, Eila Repo-Tiihonen, Tero Hallikainen, Ed Silva, Oddur Ingimarsson, Engilbert Sigurdsson, James L. Kennedy, Patrick F. Sullivan, Marcella Rietschel, Gerome Breen, Hreinn Stefansson, Kari Stefansson, David A. Collier, Michael C. O’Donovan, Ina Giegling
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia. The mechanism by which it doe
Externí odkaz:
https://doaj.org/article/3e7acd5af1d24e59bdc677f481e3c373
Publikováno v:
Mental Illness, Vol 4, Iss 1, Pp e1-e1 (2012)
There is a considerable disparity between clinical practice and recommendations based on meta-analyses of antipsychotic polypharmacy in clozapine resistant schizophrenia. For this reason, we investigated the clinical response to reducing the use olan
Externí odkaz:
https://doaj.org/article/2a21b2730e744222a55f497bbae3f37f
Autor:
Maarten Bak, Selene R. T. Veerman, H. Tuppurainen, K. van Eijk, C. Morgenroth, M. Edlinger, S. Schreiter, S. Leucht, E. Jeger-Land, G. Yoca, I.M. Erdogan, Aygun Ertugrul, M. Lähteenvuo, Tero Hallikainen, J. Tiihonen, K.P. Grootens, A. Narang, Bochao Lin, W. Alink, S.E. Legge, M.Z. van der Horst, T. Görlitz, Yavuz Ayhan, Chad A. Bousman, A. Hasan, A.E. Anil Yağcıoğlu, D Cohen, Antonio F. Pardiñas, A. Müderrisoğlu, C. Pantelis, A. Bouhuis, S. Ripke, Eila Repo-Tiihonen, Ian P. Everall, J P A M Bogers, J. Schneider-Thoma, E. Beld, Cynthia Okhuijsen-Pfeifer, Melih O. Babaoglu, J.T.R. Walters, M. de Vos, M. de Koning, T. Oviedo-Salcedo, Jurjen J. Luykx, E. Wagner, H. van Beek, M. Veereschild, S. Gutwinski
Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28540b11031415a11170bb14f98d6f87
https://doi.org/10.1101/2021.06.06.21258200
https://doi.org/10.1101/2021.06.06.21258200
Autor:
Anu Putkonen, Ina Giegling, D. A. Collier, Jan P.A.M. Bogers, Michael Conlon O'Donovan, Emil L. Sigurdsson, Jari Tiihonen, James L. Kennedy, Annette M. Hartmann, Dan Rujescu, Munir Pirmohamed, Dan Cohen, Tero Hallikainen, Oddur Ingimarsson, Eila Repo-Tiihonen, Marcella Rietschel, Patrick Sullivan, Sophie E. Legge, Bettina Konte, James T.R. Walters, Edward Silva, Hreinn Stefansson, K. van der Weide, Gerome Breen, Antonio F. Pardiñas, J. van der Weide
Publikováno v:
European Neuropsychopharmacology. 29:S1320-S1321
Autor:
Edward Silva, Jan P.A.M. Bogers, Munir Pirmohamed, Engilbert Sigurdsson, Daniel J. Cohen, Sophie E. Legge, Bettina Konte, Eila Repo-Tiihonen, Oddur Ingimarsson, Ina Giegling, D. A. Collier, Dan Rujescu, Anu Putkonen, Marcella Rietschel, Patrick Sullivan, Michael Conlon O'Donovan, Tero Hallikainen, James L. Kennedy, Annette M. Hartmann, Gerome Breen, J. van der Weide, Hreinn Stefansson, K. van der Weide, Jari Tiihonen
Publikováno v:
European Neuropsychopharmacology. 29:S939
Background The atypical antipsychotic drug clozapine is the only effective drug for treatment-resistant schizophrenia, but also bears the risk of inducing severe adverse drug responses like neutropenia and agranulocytosis. Agranulocytosis and neutrop
Autor:
Eila Repo-Tiihonen, Jan P.A.M. Bogers, Engilbert Sigurdsson, Tero Hallikainen, Munir Pirmohamed, E. Silva, Oddur Ingimarsson, James L. Kennedy, Jari Tiihonen, Anu Putkonen, Patrick Sullivan, Bettina Konte, James T.R. Walters, Marcella Rietschel, Karen van der Weide, Daniel J. Cohen, Ina Giegling, Michael Conlon O'Donovan, David A. Collier, Hreinn Stefansson, Jan van der Weide, Gerome Breen, Dan Rujescu, Sophie E. Legge, Annette M. Hartmann
Publikováno v:
European Neuropsychopharmacology. 29:S866
Background The atypical antipsychotic drug clozapine is the only effective drug for treatment-resistant schizophrenia, but also bears the risk of inducing severe adverse drug responses including neutropenia and agranulocytosis. Agranulocytosis and ne
Autor:
Eila, Repo-Tiihonen, Tero, Hallikainen
Publikováno v:
Duodecim; laaketieteellinen aikakauskirja. 132(2)
Antisocial personality disorder (ASP), especially psychopathy as its extreme form, has provoked fear and excitement over thousands of years. Ruthless violence involved in the disorder has inspired scientists, too.The abundance of research results con
Autor:
Herbert Y. Meltzer, Qian Zhao, Anu Putkonen, Eila Repo-Tiihonen, Peter B. Rosenquist, David Goldstein, Jessica M. Maia, Elizabeth T. Cirulli, Deborah L. Levy, Erin L. Heinzen, Min He, Curtis Gumbs, Dongliang Ge, Joseph P. McEvoy, Anna C. Need, Jari Tiihonen, Linda Hong, Kevin V. Shianna, Massimo Gennarelli, C. Ryan Campbell, Tero Hallikainen
Publikováno v:
The American Journal of Human Genetics. 91(2):303-312
Schizophrenia is a severe psychiatric disorder with strong heritability and marked heterogeneity in symptoms, course, and treatment response. There is strong interest in identifying genetic risk factors that can help to elucidate the pathophysiology
Autor:
Tero, Hallikainen, Eila, Repo-Tiihonen
Publikováno v:
Duodecim; laaketieteellinen aikakauskirja. 131(15)
Risk for violence in psychosis is associated with the subject's history of early-onset antisocial behavior, substance abuse, suicidal ideation, lack of insight, and non-adherence to antipsychotic medication. These risk factors can be managed by effec
Publikováno v:
Neuropsychobiology. 51:173-176
Depressive symptoms are found at any stage of schizophrenia, and antidepressant medication may be beneficial. Selective serotonin reuptake inhibitor antidepressants have been considered safe in schizophrenia but in combination with clozapine, that is