Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tero Hallikainen"'
Autor:
Bettina Konte, James T. R. Walters, Dan Rujescu, Sophie E. Legge, Antonio F. Pardiñas, Dan Cohen, Munir Pirmohamed, Jari Tiihonen, Annette M. Hartmann, Jan P. Bogers, Jan van der Weide, Karen van der Weide, Anu Putkonen, Eila Repo-Tiihonen, Tero Hallikainen, Ed Silva, Oddur Ingimarsson, Engilbert Sigurdsson, James L. Kennedy, Patrick F. Sullivan, Marcella Rietschel, Gerome Breen, Hreinn Stefansson, Kari Stefansson, David A. Collier, Michael C. O’Donovan, Ina Giegling
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia. The mechanism by which it doe
Externí odkaz:
https://doaj.org/article/3e7acd5af1d24e59bdc677f481e3c373
Publikováno v:
Mental Illness, Vol 4, Iss 1, Pp e1-e1 (2012)
There is a considerable disparity between clinical practice and recommendations based on meta-analyses of antipsychotic polypharmacy in clozapine resistant schizophrenia. For this reason, we investigated the clinical response to reducing the use olan
Externí odkaz:
https://doaj.org/article/2a21b2730e744222a55f497bbae3f37f
Autor:
Maarten Bak, Selene R. T. Veerman, H. Tuppurainen, K. van Eijk, C. Morgenroth, M. Edlinger, S. Schreiter, S. Leucht, E. Jeger-Land, G. Yoca, I.M. Erdogan, Aygun Ertugrul, M. Lähteenvuo, Tero Hallikainen, J. Tiihonen, K.P. Grootens, A. Narang, Bochao Lin, W. Alink, S.E. Legge, M.Z. van der Horst, T. Görlitz, Yavuz Ayhan, Chad A. Bousman, A. Hasan, A.E. Anil Yağcıoğlu, D Cohen, Antonio F. Pardiñas, A. Müderrisoğlu, C. Pantelis, A. Bouhuis, S. Ripke, Eila Repo-Tiihonen, Ian P. Everall, J P A M Bogers, J. Schneider-Thoma, E. Beld, Cynthia Okhuijsen-Pfeifer, Melih O. Babaoglu, J.T.R. Walters, M. de Vos, M. de Koning, T. Oviedo-Salcedo, Jurjen J. Luykx, E. Wagner, H. van Beek, M. Veereschild, S. Gutwinski
Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28540b11031415a11170bb14f98d6f87
https://doi.org/10.1101/2021.06.06.21258200
https://doi.org/10.1101/2021.06.06.21258200
Autor:
Eila Repo-Tiihonen, Jan P.A.M. Bogers, Engilbert Sigurdsson, Tero Hallikainen, Munir Pirmohamed, E. Silva, Oddur Ingimarsson, James L. Kennedy, Jari Tiihonen, Anu Putkonen, Patrick Sullivan, Bettina Konte, James T.R. Walters, Marcella Rietschel, Karen van der Weide, Daniel J. Cohen, Ina Giegling, Michael Conlon O'Donovan, David A. Collier, Hreinn Stefansson, Jan van der Weide, Gerome Breen, Dan Rujescu, Sophie E. Legge, Annette M. Hartmann
Publikováno v:
European Neuropsychopharmacology. 29:S866
Background The atypical antipsychotic drug clozapine is the only effective drug for treatment-resistant schizophrenia, but also bears the risk of inducing severe adverse drug responses including neutropenia and agranulocytosis. Agranulocytosis and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c273e1714cca8baacca193ac7e36e2
https://doi.org/10.1016/j.euroneuro.2017.08.154
https://doi.org/10.1016/j.euroneuro.2017.08.154
Autor:
Eila, Repo-Tiihonen, Tero, Hallikainen
Publikováno v:
Duodecim; laaketieteellinen aikakauskirja. 132(2)
Antisocial personality disorder (ASP), especially psychopathy as its extreme form, has provoked fear and excitement over thousands of years. Ruthless violence involved in the disorder has inspired scientists, too.The abundance of research results con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f2062335060a0b3b1feb444a14d68ca
https://pubmed.ncbi.nlm.nih.gov/26939485
https://pubmed.ncbi.nlm.nih.gov/26939485
Autor:
Herbert Y. Meltzer, Qian Zhao, Anu Putkonen, Eila Repo-Tiihonen, Peter B. Rosenquist, David Goldstein, Jessica M. Maia, Elizabeth T. Cirulli, Deborah L. Levy, Erin L. Heinzen, Min He, Curtis Gumbs, Dongliang Ge, Joseph P. McEvoy, Anna C. Need, Jari Tiihonen, Linda Hong, Kevin V. Shianna, Massimo Gennarelli, C. Ryan Campbell, Tero Hallikainen
Publikováno v:
The American Journal of Human Genetics. 91(2):303-312
Schizophrenia is a severe psychiatric disorder with strong heritability and marked heterogeneity in symptoms, course, and treatment response. There is strong interest in identifying genetic risk factors that can help to elucidate the pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78e6723550d384b80d8a6ef50de0fec
Autor:
Tero, Hallikainen, Eila, Repo-Tiihonen
Publikováno v:
Duodecim; laaketieteellinen aikakauskirja. 131(15)
Risk for violence in psychosis is associated with the subject's history of early-onset antisocial behavior, substance abuse, suicidal ideation, lack of insight, and non-adherence to antipsychotic medication. These risk factors can be managed by effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0bb4b18b67dcba4e6ee445bb4c6544dd
https://pubmed.ncbi.nlm.nih.gov/26427235
https://pubmed.ncbi.nlm.nih.gov/26427235
Publikováno v:
Neuropsychobiology. 51:173-176
Depressive symptoms are found at any stage of schizophrenia, and antidepressant medication may be beneficial. Selective serotonin reuptake inhibitor antidepressants have been considered safe in schizophrenia but in combination with clozapine, that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343b535d75dd52867eec68202c0796a3
https://doi.org/10.1159/000085591
https://doi.org/10.1159/000085591
Autor:
J.L. Kennedy, Anu Putkonen, Jari Tiihonen, Daniel J. Müller, Nabilah I. Chowdhury, Clement C. Zai, Arun K. Tiwari, Herbert Y. Meltzer, Tero Hallikainen, Falk W. Lohoff, Eila Repo-Tiihonen, Anna C. Need, A.E. Anıl Yağcıoğlu
Publikováno v:
Molecular Psychiatry. 19:403-405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb4fe17383855398a5a859a1acce362
https://doi.org/10.1038/mp.2013.74
https://doi.org/10.1038/mp.2013.74
Autor:
Tero Hallikainen, Jari Tiihonen, Tiina Pohjalainen, Erkka Syvälahti, Jukka T. Salonen, Jarmo Hietala, Jussi Kauhanen
Publikováno v:
American Journal of Medical Genetics Part A. :152-155
The dopaminergic system in the human brain is thought to play a major role in the development of alcohol consumption habits and alcoholism. It has been reported that homozygous D2-/- knock-out mice lacking D2 receptors consume about 50% to 60% less e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65066a63afc3fbe62c4ad20756b73042
https://doi.org/10.1002/ajmg.a.20139
https://doi.org/10.1002/ajmg.a.20139