Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Terminal loop"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Differential processing is a hallmark of clustered microRNAs (miRNAs) and the role of position and order of miRNAs in a cluster together with the contribution of stem-base and terminal loops has not been explored extensively within the context of a p
Externí odkaz:
https://doaj.org/article/fcaf8a632c304984a352403620341058
Akademický článek
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Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The blockade of immune checkpoints, such as programmed death receptor 1 (PD-1) and programmed death ligand 1 protein (PD-L1), is a promising therapeutic approach in cancer immunotherapy. Nivolumab, a humanized IgG4 antibody targeting PD-1, was approv
Externí odkaz:
https://doaj.org/article/db9d28450d8d4dc89153c764f9c935e8
Autor:
Insun Kook, Joseph M. Ziegelbauer
Publikováno v:
Nucleic Acids Res
Kaposi's sarcoma-associated herpesvirus (KSHV) expresses miRNAs during latency. However, regulation of viral miRNAs remains largely unknown. Our prior studies demonstrated that MCPIP1 regulates KSHV miRNA biogenesis by degrading most KSHV pre-miRNAs
Autor:
Xianzhang Bu, Anlong Xu, Heng Liang, Chuwei Liu, Dongshi Chen, Yi Niu, Guohui Wan, Siyue Zhan, Zhuolong Zhou, Arabella Wan, Lei Sun, Xiongbin Lu, Shijia Yan, Shanfeng Wang, Ziyou Lin, Weiling He
Publikováno v:
Gut
ObjectiveDysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.DesignWe analysed altered gene signatures during colorec
Publikováno v:
RNA
Correct cellular localization is essential for the function of many eukaryotic proteins and hence cell physiology. Here, we present a synthetic genetic device that allows the control of nuclear and cytosolic localization based on controlled alternati
Autor:
Hyun Ho Park, Hyun Ji Ha
Publikováno v:
FEBS Letters. 594:2396-2405
Members of the NLR family pyrin domain containing (NLRPs) are pattern recognition receptors that participate in innate immunity. They form inflammasomes, which are platforms for caspase-1 recruitment and activation. The NLRP pyrin domain (PYD) is cri
Autor:
Yuren Adam Yuan, Chacko Jobichen, Wei Chen, Jianwei Li, Meng Sun, Yu-Keung Mok, JingRu Chan, Gayathiri Sathyamoorthy Kannan, Ying Chen
Publikováno v:
RNA
microRNAs (miRNAs), a class of small and endogenous molecules that control gene expression, are broadly involved in biological processes. Although a number of cofactors that assist or antagonize let-7 miRNA biogenesis are well-established, more auxil
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The crystal structure of the oxidized form of a human mitochondrial branched-chain aminotransferase (hBCATm) mutant was determined. The structural analysis supports the concept that a complex regulation mechanism is involved in hBCATm activity, which
Publikováno v:
Journal of agricultural and food chemistry. 69(46)
IGPD is an essential metalloenzyme that catalyzes histidine biosynthesis. We found that its C-terminus loop region has a vital role in determining enzyme activity but has been hardly mentioned before. In this work, we focused on the dynamic feature a