Výsledky vyhledávání - "Terminal amine isotopic labeling of substrates"

Akademický článek

Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza

Autor: Sira C. Günther, Carles Martínez-Romero, Milagros Sempere Borau, Christine T. N. Pham, Adolfo García-Sastre, Silke Stertz

Publikováno v: Microbiology Spectrum, Vol 10, Iss 4 (2022)

ABSTRACT Influenza A virus (IAV) coopts numerous host factors for efficient replication. The cysteine protease cathepsin W (CTSW) has been identified as one host factor required for IAV entry, specifically for the escape of IAVs from late endosomes.

Externí odkaz: https://doaj.org/article/328d2796bc78464390cf1a5669260d23

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Venom Profiling of the Insular Species Bothrops alcatraz: Characterization of Proteome, Glycoproteome, and N-Terminome Using Terminal Amine Isotopic Labeling of Substrates

Autor: Solange M.T. Serrano, Silvia Regina Travaglia-Cardoso, Débora Andrade-Silva, Milton Y. Nishiyama, André Zelanis

Publikováno v: Journal of Proteome Research. 20:1341-1358

Bothrops alcatraz, a species endemic to Alcatrazes Islands, is regarded as critically endangered due to its small area of occurrence and the declining quality of its habitat. We recently reported the identification of N-glycans attached to toxins of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e5dfe99f05b1cb679cb695eba611d6a
https://doi.org/10.1021/acs.jproteome.0c00737

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Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza

Autor: Günther, Sira C, Martínez-Romero, Carles, Sempere Borau, Milagros, Pham, Christine T N, García-Sastre, Adolfo, Stertz, Silke

Publikováno v: Microbiology Spectrum, 10 (4)

Influenza A virus (IAV) coopts numerous host factors for efficient replication. The cysteine protease cathepsin W (CTSW) has been identified as one host factor required for IAV entry, specifically for the escape of IAVs from late endosomes. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69eb1c7fa658b4251e38820fe03b3291

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Isolation of acetylated and unmodified protein N-Terminal peptides by strong cation exchange chromatographic separation of TrypN-digested peptides

Autor: Juri Rappsilber, Hsin Yi Chang, Chih-Hsiang Chang, Yasushi Ishihama

Publikováno v: Chang, C-H, Chang, H-Y, Rappsilber, J & Ishihama, Y 2021, ' Isolation of acetylated and unmodified protein N-Terminal peptides by strong cation exchange chromatographic separation of TrypN-digested peptides ', Molecular and Cellular Proteomics, vol. 20, 100003 . https://doi.org/10.1074/mcp.TIR120.002148
Molecular & Cellular Proteomics : MCP

We developed a simple and rapid method to enrich protein N-terminal peptides, in which the protease TrypN is first employed to generate protein N-terminal peptides without Lys or Arg and internal peptides with two positive charges at their N termini,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adcd37498cce942d869fe34bcfdff9c
https://www.pure.ed.ac.uk/ws/files/193968213/PIIS1535947620350428.pdf

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Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics

Autor: André Zelanis, Solange M.T. Serrano, Christopher M. Overall, Pitter F. Huesgen, Jayachandran N. Kizhakkedathu, Ana Oliveira, Alexandre Keiji Tashima, Anna Prudova

Publikováno v: Journal of Proteome Research. 18:3419-3428

Snakebite is a major medical concern in many parts of the world with metalloproteases playing important roles in the pathological effects of Viperidae venoms, including local tissue damage, hemorrhage, and coagulopathy. Hemorrhagic Factor 3 (HF3), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54003c82e079fdc2e311317cb467fd0d
https://doi.org/10.1021/acs.jproteome.9b00325

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TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease

Autor: Dylan Laprise, Virendar K. Kaushik, Steven A. Carr, Karl R. Clauser, Kayla Bendinelli, Bryan T. MacDonald, Charles C Mundorff, Yi Xing, Hasmik Keshishian, Alessandro Arduini, Daniel Lai, Bidur Bhandary, Nicholas R Popp, Patrick T. Ellinor, Harrison Specht, Nadine H. Elowe

Publikováno v: Molecular & Cellular Proteomics. 21:100223

Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs 7) are associated with protection for coronary artery disease (CAD). ADAMTS7 catalytic inhibition has been proposed as a therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2338f2edcdd9eb631849088510d94b3
https://doi.org/10.1016/j.mcpro.2022.100223

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The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors

Autor: Nabangshu Das, Antoine Dufour, Colette Benko, Sean E. Gill

Publikováno v: Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 31, p 31 (2021)

Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat®, have failed in Phase III clinical trials. As an alternative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fde57a43301d567a1dee14438850583
http://europepmc.org/articles/PMC7823758

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Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components

Autor: Suneel S. Apte, Carmela D. Tan, Belinda Willard, Deborah E Seifert, Eugene H. Blackstone, E. Rene Rodriguez, Gösta B. Pettersson, Daniel R. Martin, James C. Witten

Publikováno v: JCI Insight

Infective endocarditis is a life-threatening infection of heart valves and adjacent structures characterized by vegetations on valves and other endocardial surfaces, with tissue destruction and risk of embolization. We used high-resolution mass spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03165accdede85a3b4513a7cc1a9a24d
https://doi.org/10.1172/jci.insight.135317

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The distinct N-terminomes of Bothrops jararaca newborn and adult venoms

Autor: Solange M.T. Serrano, André Zelanis, Débora Andrade-Silva, Milton Y. Nishiyama, Daniel Rodrigues Stuginski

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1869:140643

Using approaches of transcriptomics and proteomics we have shown that the phenotype of Bothrops jararaca venom undergoes a significant rearrangement upon neonate to adult transition. Most regulatory processes in biology are intrinsically related to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb4a2541a506d05a58b54e9954747e9
https://doi.org/10.1016/j.bbapap.2021.140643

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Comprehensive Analysis of Protein N-Terminome by Guanidination of Terminal Amines

Autor: Xiaodan Zhang, Yukui Zhang, Yang Kaiguang, Lihua Zhang, Xiao Li, Li Yang, Mingwei Sun, Yichu Shan, Baofeng Zhao, Yu Liang, Huiming Yuan, Zhen Liang

Publikováno v: Analytical chemistry. 92(1)

Protein N-termini and their modifications not only represent different protein isoforms but also relate to the functional annotation and proteolytic activities. Currently, negative selection methods, such as terminal amine isotopic labeling of substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a530cd4b8c1ae1c77a2382707dec37f9
https://pubmed.ncbi.nlm.nih.gov/31846294

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