Výsledky vyhledávání - "Teri Johnson"

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

Autor: James P. Calvet, Darren P. Wallace, Brenda S. Magenheimer, Teri Johnson, Xiaogang Li, Rong Li, Sheng Xia

Publikováno v: Nature Medicine. 14:863-868

Polycystic kidney disease can be caused by germline mutations in the gene encoding PC2 followed by a second somatic 'hit' in the normal allele. Li and her colleagues now show that TNF-α can also act as a second hit and that disease progression can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dc35381cb7b7a895ed62ade353163c
https://doi.org/10.1038/nm1783

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RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development

Autor: Karen Staehling-Hampton, Paul A. Trainor, Jian Xing Ma, Jean Philippe Rey, Brian W. Sanderson, Arcady Mushegian, Gennadiy Moiseyev, Kendra Young, Lisa L. Sandell, Teri Johnson

Publikováno v: Genes & Development. 21:1113-1124

Regulation of patterning and morphogenesis during embryonic development depends on tissue-specific signaling by retinoic acid (RA), the active form of Vitamin A (retinol). The first enzymatic step in RA synthesis, the oxidation of retinol to retinal,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba598e1df417badb24d49196a85ab4e
https://doi.org/10.1101/gad.1533407

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PTEN-deficient intestinal stem cells initiate intestinal polyposis

Autor: Qiang Tian, Leroy Hood, Terrence A. Barrett, Leanne M. Wiedemann, Tong Yin, Mark Hembree, Hong Wu, Teri Johnson, Raminarao Dirisina, Kimberly S. Porter-Westpfahl, Linheng Li, Xi C. He, Toshiro Sato, W. Andy Tao, Justin C. Grindley

Publikováno v: Nature Genetics. 39:189-198

Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40155f8303827ef6f3ababe1a44439d4
https://doi.org/10.1038/ng1928

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Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

Autor: Wei‐Gang Tong, Xi C. He, Jiwang Zhang, Yuji Mishina, Leanne M. Wiedemann, Jian Q. Feng, Teri Johnson, Linheng Li

Publikováno v: STEM CELLS. 24:2826-2839

Epithelial stem cells (EP-SCs) located in the bulge region of a hair follicle (HF) have the potential to give rise to hair follicle stem/progenitor cells that migrate down to regenerate HFs. Bone morphogenetic protein (BMP) signaling has been shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e847101f1c977506c8601235efae63e7
https://doi.org/10.1634/stemcells.2005-0544

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The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development

Autor: Jinyu Ren, Mingan Shi, Teri Johnson, William C. Skarnes, Renshui Liu, Chunying Du, Qi-Heng Yang

Publikováno v: Proceedings of the National Academy of Sciences. 102:565-570

Baculoviral inhibitor of apoptosis repeat-containing (Birc)6 gene/BIRC6 (Bruce/APOLLON) encodes an inhibitor of apoptosis and a chimeric E2/E3 ubiquitin ligase in mammals. The physiological role of Bruce in antiapoptosis is unknown. Here, we show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23303c8a840f59e232767a1a17cf7e15
https://doi.org/10.1073/pnas.0408744102

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Identification of the haematopoietic stem cell niche and control of the niche size

Autor: Haiyang Huang, Linheng Li, Leanne M. Wiedemann, Wei Gang Tong, Stephen E. Harris, Jeffrey S. Haug, Jiwang Zhang, Jian Q. Feng, Jason Ross, Teri Johnson, Ling Ye, Yuji Mishina, Chao Niu, Xi C. He

Publikováno v: Nature. 425:836-841

Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche'--the in vivo regulatory microenvironment where HSCs reside--and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643f435f7a6954b685a9037d812b0f01
https://doi.org/10.1038/nature02041

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Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

Autor: Chris Seidel, Teri Johnson, Xiaogang Li, Darren P. Wallace, Rong Li, Sheng Xia

Polycystin 1 and polycystin 2 are large transmembrane proteins, which, when mutated, cause autosomal dominant polycystic kidney disease (ADPKD), a highly prevalent human genetic disease. The polycystins are thought to form a receptor-calcium channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effb92421a894eef924b620de258f72c
https://europepmc.org/articles/PMC2835323/

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Hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in Drosophila prometaphase oocytes

Autor: William D. Gilliland, R. Scott Hawley, Dana L. Vietti, Teri Johnson, Fengli Guo, Nicole M. Schweppe

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7544 (2009)
PLoS ONE

Background The protein kinases Mps1 and Polo, which are required for proper cell cycle regulation in meiosis and mitosis, localize to numerous ooplasmic filaments during prometaphase in Drosophila oocytes. These filaments first appear throughout the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a21979ea30aa6e37b826ad6a6facf6
http://europepmc.org/articles/PMC2761730?pdf=render

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