Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Terhi Peuralinna"'
Autor:
Tuomo Polvikoski, David J. Stone, Raimo Sulkava, Terhi Peuralinna, Hanna Ollila, Hilkka Soininen, Pentti J. Tienari, Alan E. Renton, Sonja Sulkava, Pranuthi Muggalla, Henri J. Huttunen, Seppo Helisalmi, Karri Kaivola, Tiina Paunio, Bryan J. Traynor, Alberto M. Rivera, Mikko Hiltunen, Liisa Myllykangas
Publikováno v:
Sleep
Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer’s disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer’s disease. Previously, we have reported association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31da459786cc8ab7b0ddc1122ef6bb73
https://doi.org/10.1093/sleep/zsy103
https://doi.org/10.1093/sleep/zsy103
Autor:
Carol Brayne, Tuomo Polvikoski, Mike A. Nalls, Veli-Matti Isoviita, John Hardy, Paul G. Ince, Minna Oinas, Raimo Sulkava, Terhi Peuralinna, Julia Zaccai, Hannah A.D. Keage, Andrew B. Singleton, Miko Valori, Anders Paetau, Liisa Myllykangas, Bryan J. Traynor, Pentti J. Tienari
Publikováno v:
Annals of Clinical and Translational Neurology
Objective Dementia with Lewy bodies is an α-synucleinopathy characterized by neocortical Lewy-related pathology (LRP). We carried out a genome-wide association study (GWAS) on neocortical LRP in a population-based sample of subjects aged 85 or over.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2188963f8ada00018acfe8a0ee52cf19
https://doi.org/10.1002/acn3.231
https://doi.org/10.1002/acn3.231
Autor:
Paul M. Matthews, Anne-Mari Kantanen, Dena G. Hernandez, David A. Hosford, Mohamad A. Mikati, Heinz Gregor Wieser, Sarah K. Tate, Günter Krämer, Reetta Kälviäinen, Jörg Hansen, Lefkos T. Middleton, Bernhard J. Steinhoff, Dominik Zumsteg, Josemir W. Sander, Massimo Pandolfo, Leslie Amos, Norman Delanty, Saud Alhusaini, David Goldstein, Marvin Johnson, Krishna Chinthapalli, John S. Duncan, Marcos Ortega, Sanjay M. Sisodiya, Leif Gjerstad, Aatif M. Husain, Chantal Depondt, Kai Eriksson, Dalia Kasperavičiūtė, David Leppert, Jenny Jamnadas-Khoda, Erin L. Heinzen, Terhi Peuralinna, Claudia B. Catarino, Rodney A. Radtke, Colin P. Doherty, Kevin V. Shianna, Lisa M. S. Clayton, Luis O. Caboclo, Thomas Dorn, William Gallentine, Nicholas W. Wood, Kjell Heuser, Gianpiero L. Cavalleri, Rachel A. Gibson
Publikováno v:
Brain
Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02403ba1003d2fdaebea642438b670ca
http://doc.rero.ch/record/295093/files/awq130.pdf
http://doc.rero.ch/record/295093/files/awq130.pdf
Autor:
Terhi Peuralinna, Tuomo Polvikoski, Andrew B. Singleton, Liisa Myllykangas, Miko Valori, David J. Stone, Bryan J. Traynor, Maarit Tanskanen, Mira Mäkelä, Anders Paetau, Karri Kaivola, Pentti J. Tienari
Publikováno v:
Neurology: Genetics
ObjectiveTo test the association of distinct neuropathologic features of Alzheimer disease (AD) with risk loci identified in genome-wide association studies.MethodsVantaa 85+ is a population-based study that includes 601 participants aged ≥85 years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99f44e3bcbc0b8560743d224ae2ceef
https://pubmed.ncbi.nlm.nih.gov/29379882
https://pubmed.ncbi.nlm.nih.gov/29379882
Autor:
Lilja Jansson, Terhi Peuralinna, Shaoi-Lin Lai, Pentti J. Tienari, Dena G. Hernandez, David Heckerman, Sonja W. Scholz, Hannu Laaksovirta, Liisa Myllykangas, J. Raphael Gibbs, Raimo Sulkava, Bryan J. Traynor, Mike A. Nalls, Jennifer C. Schymick
Publikováno v:
The Lancet Neurology. 9:978-985
Summary Background The genetic cause of amyotrophic lateral sclerosis (ALS) is not well understood. Finland is a well suited location for a genome-wide association study of ALS because the incidence of the disease is one of the highest in the world,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04b59bc9a326763385e2be9665ddec3
https://doi.org/10.1016/s1474-4422(10)70184-8
https://doi.org/10.1016/s1474-4422(10)70184-8
Autor:
Andrew B. Singleton, Tuomo Polvikoski, Anders Paetau, John Hardy, Leena Niinistö, Pentti J. Tienari, Raimo Sulkava, Hannu Kalimo, Terhi Peuralinna, Dena G. Hernandez, Liisa Myllykangas, Minna Oinas
Publikováno v:
Annals of Neurology. 64:348-352
We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde6466264df6b8817d4cb7454e83d2d
https://doi.org/10.1002/ana.21446
https://doi.org/10.1002/ana.21446
Autor:
Pentti J. Tienari, Liisa Myllykangas, Raimo Sulkava, Irma-Leena Notkola, Andrew B. Singleton, Sari Kiuru-Enari, Terhi Peuralinna, Tuomo Polvikoski, Anders Paetau, Maarit Tanskanen, John Hardy
Publikováno v:
Annals of Medicine. 40:232-239
Senile systemic amyloidosis (SSA) is characterized by deposition of wild-type transthyretin (TTR)-based amyloid in parenchymal organs in elderly individuals. Previously, no population-based studies have been performed on SSA.Here we have studied the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4921de9927d0977299186d6ff0832f1
https://doi.org/10.1080/07853890701842988
https://doi.org/10.1080/07853890701842988
Autor:
Pentti J. Tienari, Maarit Tanskanen, Andrew B. Singleton, John Hardy, Mira Mäkelä, Hannu Kalimo, Shiao-lin Lai, Tuomo Polvikoski, Anders Paetau, Raimo Sulkava, Sampath Arepalli, Terhi Peuralinna, Liisa Myllykangas, Bryan J. Traynor, Dena G. Hernandez
Publikováno v:
Journal of Alzheimer's disease : JAD. 26(2)
Cortical and cerebrovascular amyloid-beta (A-beta) deposition is a hallmark of Alzheimer’s disease (AD), but also occurs in elderly people not affected by dementia. The apolipoprotein E (APOE) epsilon4 is a major genetic modulator of A-beta deposit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9122b28824fb7d5a5dae9065633faf
https://pubmed.ncbi.nlm.nih.gov/21654062
https://pubmed.ncbi.nlm.nih.gov/21654062
Autor:
Pentti J. Tienari, Andrew B. Singleton, Petri Luoma, Sonja W. Scholz, Anu Suomalainen, Coro Paisán-Ruiz, Terhi Peuralinna, J. Eerola
A possible role of allelic variation of the mitochondrial DNA polymerase gamma (POLG I) gene in Parkinson's disease (PD) has been suggested. First, POLG I missense mutations have been found in patients with familial parkinsonism and mitochondrial myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a373ecfe257265c42a61fba9f9fcf76
https://europepmc.org/articles/PMC2905783/
https://europepmc.org/articles/PMC2905783/
Autor:
Terhi, Peuralinna, Minna, Oinas, Tuomo, Polvikoski, Anders, Paetau, Raimo, Sulkava, Leena, Niinistö, Hannu, Kalimo, Dena, Hernandez, John, Hardy, Andrew, Singleton, Pentti J, Tienari, Liisa, Myllykangas
Publikováno v:
Ann Neurol
We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::602be6a3825e0a7d6ab891802f315033
https://pubmed.ncbi.nlm.nih.gov/18661559
https://pubmed.ncbi.nlm.nih.gov/18661559