Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

Autor: Sawan Kumar Jha, Khushbu Rauniyar, Terhi Karpanen, Veli-Matti Leppänen, Pascal Brouillard, Miikka Vikkula, Kari Alitalo, Michael Jeltsch

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract The collagen- and calcium-binding EGF domains 1 (CCBE1) protein is necessary for lymphangiogenesis. Its C-terminal collagen-like domain was shown to be required for the activation of the major lymphangiogenic growth factor VEGF-C (Vascular E

Externí odkaz: https://doaj.org/article/d11b857cbde0493591e19aca144a0242

An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation

Autor: Naoki Mochizuki, Nanami Morooka, Dörte Schulte, Kiyotoshi Sekiguchi, Cathrin Dierkes, Yvonne Padberg, Glenn van de Hoek, Stefan Schulte-Merker, Josi Peterson-Maduro, Friedemann Kiefer, Terhi Karpanen, Max Adrian, Serge A. van de Pavert

Publikováno v: Circulation Research
Circulation Research, 120(8), 1263. Lippincott Williams and Wilkins

Supplemental Digital Content is available in the text.
Rationale: Lymphatic vessel formation and function constitutes a physiologically and pathophysiologically important process, but its genetic control is not well understood. Objective: Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f7323555cf499756fed3654f836165
http://europepmc.org/articles/PMC5389596

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

Autor: Terhi Karpanen, Kalevi J. Pulkkanen, Shin-Ichi Nishikawa, Taija Makinen, Hajime Kubo, Risto A. Kauppinen, Tanja Veikkola, Kari Alitalo, Mikko I. Kettunen, David A. Jackson, Seppo Ylä-Herttuala, Lotta Jussila

The lymphatic vasculature transports extravasated tissue fluid, macromolecules and cells back into the blood circulation. Recent reports have focused on the molecular mechanisms regulating the lymphatic vessels. Vascular endothelial growth factor (VE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5725d820d280df5adfe6180d781e4c1
https://ora.ox.ac.uk/objects/uuid:871297f7-813b-450e-932b-f47ea1092af0

CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo

Autor: Stefan Schulte-Merker, Joe Kowalski, Eckhard Lammert, Jeroen Korving, Frank L. Bos, Johan H. van Es, Terhi Karpanen, Andreas van Impel, Lara Planas-Paz, Maresa Caunt, Raymond K. Tong, Henricus J. Duckers, James A. Ernst, Josi Peterson-Maduro

Publikováno v: Circulation Research, 109, 486-491
Circulation Research 109 (2011)
Circulation Research, 109(5), 486-491. Lippincott Williams & Wilkins
Circulation Research, 109(5), 486-U81. Lippincott Williams & Wilkins

Rationale: Collagen- and calcium-binding EGF domains 1 (CCBE1) has been associated with Hennekam syndrome, in which patients have lymphedema, lymphangiectasias, and other cardiovascular anomalies. Insight into the molecular role of CCBE1 is completel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d51480739aaf3b09891cc516a3938cf
https://doi.org/10.1161/circresaha.111.250738

Molecular Biology and Pathology of Lymphangiogenesis

Autor: Kari Alitalo, Terhi Karpanen

Publikováno v: Annual Review of Pathology: Mechanisms of Disease. 3:367-397

The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune surveillance, and adsorption fatty acids in the gut. The lymphatic vessels are also crucially involved in the pathogenesis of diseases such as tumor metastasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d0d54cd3235b6e82d16b79a5a78a80
https://doi.org/10.1146/annurev.pathmechdis.3.121806.151515