Lactic Acidosis Interferes With Toxicity of Perifosine to Colorectal Cancer Spheroids: Multimodal Imaging Analysis

Autor: Barbora Pavlatovská, Markéta Machálková, Petra Brisudová, Adam Pruška, Karel Štěpka, Jan Michálek, Tereza Nečasová, Petr Beneš, Jan Šmarda, Jan Preisler, Michal Kozubek, Jarmila Navrátilová

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Colorectal cancer (CRC) is a disease with constantly increasing incidence and high mortality. The treatment efficacy could be curtailed by drug resistance resulting from poor drug penetration into tumor tissue and the tumor-specific microenvironment,

Externí odkaz: https://doaj.org/article/9ed970cdc0f84726b73a3e573feb023d

Secondary malignancies and survival of FCR-treated patients with chronic lymphocytic leukemia in Central Europe

Autor: Fruzsina Kósa, Tereza Nečasová, Martin Špaček, Krzysztof Giannopoulos, Iwona Hus, Tereza Jurková, Eva Koriťáková, Marika Chrápavá, Martina Nováčková, Ivana Katinová, Denisa Krejčí, Adam Jujka, Zoltán Mátrai, István Vályi‐Nagy, Tadeusz Robak, Michael Doubek

Publikováno v: Cancer medicineREFERENCES.

This is the first large-scale cross-country analysis of patients with chronic lymphocytic leukemia (CLL) aimed to evaluate the incidence, types, and key prognostic factors of secondary malignancies, and to assess the impact on overall survival based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60ff3313f5160554d9cf3fbf3edfd49
https://pubmed.ncbi.nlm.nih.gov/36205198

Prediction Score for persisting perfusion defects after pulmonary embolism

Autor: Iveta Simkova, Pavel Jansa, Tereza Nečasová, Jan Mrózek, Michal Svoboda

Publikováno v: Biomedical Papers, Vol 164, Iss 4, Pp 394-400 (2020)

Aims: Long-term persistence of perfusion defect after pulmonaryembolism (PE) may lead to the development of chronic thromboembolic pulmonary hypertension. Identification of patients at risk of such a complication using a scoring system would be benef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae323bf686b03c55e95082cbba0275f
https://biomed.papers.upol.cz/artkey/bio-202004-0007_prediction-score-for-persisting-perfusion-defects-after-pulmonary-embolism.php

Validation and evaluation metrics for medical and biomedical image synthesis

Autor: Tereza Nečasová, Ninon Burgos, David Svoboda

Publikováno v: Biomedical Image Synthesis and Simulation
Biomedical Image Synthesis and Simulation, Elsevier, pp.573-600, 2022, 978-0-12-824349-7. ⟨10.1016/B978-0-12-824349-7.00032-3⟩

International audience; Synthetic image data play an important role in the verification of medical and biomedical image analysis algorithms. However the usage of such data strongly relies on their quality and plausibility. Despite the emergence of ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4165410460f31bf37483ac318a9e8c3d
https://hal.inria.fr/hal-03721947/file/BISS-Chapter25-Validation_evaluation_metrics.pdf

Drug Penetration Analysis in 3D Cell Cultures Using Fiducial-Based Semiautomatic Coregistration of MALDI MSI and Immunofluorescence Images

Autor: Jan Michálek, Jan Šmarda, Katarzyna Anna Radaszkiewicz, Tereza Nečasová, Karel Štěpka, Adam Pruška, Markéta Machálková, Jarmila Navrátilová, Barbora Pavlatovská, Michal Kozubek, Jan Preisler

Publikováno v: Analytical Chemistry. 91:13475-13484

In this paper, we present an easy-to-follow procedure for the analysis of tissue sections from 3D cell cultures (spheroids) by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) and laser scanning confocal microscopy (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7da4149752ae6112611109e66345cb4
https://doi.org/10.1021/acs.analchem.9b02462