Clusterin serum levels are elevated in patients with early rheumatoid arthritis and predict disease activity and treatment response

Autor: Tereza Kropáčková, Heřman Mann, Olga Růžičková, Olga Šléglová, Lucia Vernerová, Veronika Horváthová, Michal Tomčík, Karel Pavelka, Jiří Vencovský, Ladislav Šenolt

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Clusterin (CLU) is a molecular chaperone that participates in a variety of biological processes. Recent studies indicate its possible involvement in the development of bone erosions and autoimmunity. The aim of this study was to investigate

Externí odkaz: https://doaj.org/article/227e667eadb7435baccf2f0805b6c601

Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

Autor: Tereza Kropáčková, Olga Šléglová, Olga Růžičková, Jiří Vencovský, Karel Pavelka, Ladislav Šenolt

Publikováno v: BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-6 (2018)

Abstract Background The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and

Externí odkaz: https://doaj.org/article/9b0caefcb15a40ef9b2b233d9c326e58

Clusterin is upregulated in serum and muscle tissue in idiopathic inflammatory myopathies and associates with clinical disease activity and cytokine profile

Autor: Tereza, Kropáčková, Lucia, Vernerová, Hana, Štorkánová, Veronika, Horváthová, Martina, Vokurková, Martin, Klein, Sabína, Oreská, Maja, Špiritović, Barbora, Heřmánková, Kateřina, Kubínová, Lucie Andrés, Cerezo, Olga, Kryštůfková, Heřman, Mann, Jozef, Ukropec, Barbara, Ukropcová, Josef, Zámečník, Michal, Tomčík, Jiří, Vencovský, Ladislav, Šenolt

Publikováno v: Clinical and Experimental Rheumatology. 39:1021-1032

The aim of this cross-sectional study was to explore the circulating and skeletal muscle expression of clusterin (CLU) in inflammatory myopathies (IIM) and its potential implication in pathogenetic mechanisms of the disease.A total of 85 IIM patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac26bb550f8470b1cb898787e0a330c
https://doi.org/10.55563/clinexprheumatol/k3vtg5

Chemokine and Cytokine Profiles in Patients with Hand Osteoarthritis

Autor: Karel Pavelka, Jiří Vencovský, Michal Tomcik, Hana Hulejová, J. Baloun, Ladislav Šenolt, O. Sleglova, Jindřiška Gatterová, Olga Růžičková, Tereza Kropáčková

Publikováno v: Biomolecules, Vol 11, Iss 4, p 4 (2021)
Biomolecules
Volume 11
Issue 1

Background: The development of hand osteoarthritis (HOA) and its progression into the erosive subset are unclear, but inflammation is suspected to be the main source. To verify the involvement of inflammation in HOA pathogenesis, we evaluate serum in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9fa2c77e355398184b06fca8d90678
https://www.mdpi.com/2218-273X/11/1/4

S100A4 is elevated in axial spondyloarthritis:a potential link to disease severity

Autor: Kristýna Bubová, Lucie Andrés Cerezo, Jiří Vencovský, Hana Hulejová, J.J. Štěpán, Barbora Šumová, Karel Pavelka, Mária Filková, Mariam Grigorian, Tereza Kropáčková, Ladislav Šenolt, Michal Tomcik, Klára Prajzlerová

Publikováno v: Sumova, B, Cerezo, L A, Hulejova, H, Prajzlerova, K, Tomcik, M, Bubova, K, Stepan, J, Filkova, M, Kropackova, T, Grigorian, M, Pavelka, K, Vencovsky, J & Senolt, L 2020, ' S100A4 is elevated in axial spondyloarthritis : a potential link to disease severity ', BMC Rheumatology, vol. 4, no. 1, 13 . https://doi.org/10.1186/s41927-019-0110-7
BMC Rheumatology, Vol 4, Iss 1, Pp 1-6 (2020)
BMC Rheumatology

Background S100A4 is a member of calcium binding S100 protein family well known for its role in cancer progression and metastasis. Nevertheless, S100A4 also serves as a negative regulator of bone formation. Dickkopf-1 (DKK-1), marker of bone remodell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b80be994d64a35be980246c9839c6c
https://curis.ku.dk/ws/files/269792892/S100A4_is_elevated_in_axial_spondyloarthritis.pdf