Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Teresa W.-M. Fan"'
Autor:
Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N. Lane
Publikováno v:
Metabolites, Vol 13, Iss 7, p 774 (2023)
Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus
Externí odkaz:
https://doaj.org/article/d138aeef22d54272a4f32cf81e8a1281
Autor:
Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan, Jeffrey A. Moscow
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Background The loss-of-function mutation of fumarate hydratase (FH) is a driver of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Fumarate accumulation results in activation of stress-related mechanisms leading to upregulation o
Externí odkaz:
https://doaj.org/article/0dceb078fdad4b62bc2e715b95444bdb
Autor:
Dipanwita Sengupta, Teresa Cassel, Kun-yu Teng, Mona Aljuhani, Vivek K. Chowdhary, Peng Hu, Xiaoli Zhang, Teresa W.-M. Fan, Kalpana Ghoshal
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 174-186 (2020)
Objective: It is well established that the liver-specific miR-122, a bona fide tumor suppressor, plays a critical role in lipid homeostasis. However, its role, if any, in amino acid metabolism has not been explored. Since glutamine (Gln) is a critica
Externí odkaz:
https://doaj.org/article/e94018977b7a47ee8dc02a6ee0c626c7
Autor:
Erika M. Palmieri, Marieli Gonzalez-Cotto, Walter A. Baseler, Luke C. Davies, Bart Ghesquière, Nunziata Maio, Christopher M. Rice, Tracey A. Rouault, Teresa Cassel, Richard M. Higashi, Andrew N. Lane, Teresa W.-M. Fan, David A. Wink, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Production of inflammatory mediators by M1-polarized macrophages is thought to rely on suppression of mitochondrial metabolism in favor of glycolysis. Refining this concept, here the authors define metabolic targets of nitric oxide as responsible for
Externí odkaz:
https://doaj.org/article/1aabd0cb2c6e480fa1e6ac1eb3b1dd56
Autor:
Timothy L. Scott, Juan Zhu, Teresa A. Cassel, Sara Vicente-Muñoz, Penghui Lin, Richard M. Higashi, Andrew N. Lane, Teresa W.-M. Fan
Publikováno v:
Metabolites, Vol 12, Iss 8, p 760 (2022)
Glycogen is a readily deployed intracellular energy storage macromolecule composed of branched chains of glucose anchored to the protein glycogenin. Although glycogen primarily occurs in the liver and muscle, it is found in most tissues, and its meta
Externí odkaz:
https://doaj.org/article/130af625bf0240b28d4779f4a79268fe
Autor:
Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W.-M. Fan, Pankaj Seth
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108831- (2021)
Summary: Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide ade
Externí odkaz:
https://doaj.org/article/acce3d944b2e4a188f1edec534596d20
Autor:
Ramon C. Sun, Teresa W.-M. Fan, Pan Deng, Richard M. Higashi, Andrew N. Lane, Anh-Thu Le, Timothy L. Scott, Qiushi Sun, Marc O. Warmoes, Ye Yang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Isotope tracer administration for probing metabolism in vivo is important to assess metabolic functions in a relevant physiological setting. Here, the authors report a non-invasive method of administering 13C6- glucose to mouse models via liquid diet
Externí odkaz:
https://doaj.org/article/84d4323985664c0fb540d359fc803901
Autor:
Teresa W.-M. Fan, Salim S. El-Amouri, Jessica K. A. Macedo, Qing Jun Wang, Huan Song, Teresa Cassel, Andrew N. Lane
Publikováno v:
Metabolites, Vol 8, Iss 3, p 40 (2018)
Conventional two-dimensional (2D) cell cultures are grown on rigid plastic substrates with unrealistic concentration gradients of O2, nutrients, and treatment agents. More importantly, 2D cultures lack cell–cell and cell–extracellular matrix (ECM
Externí odkaz:
https://doaj.org/article/423d8fb11f284b058faf2cc11b54d1b1
Autor:
Lane, Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N.
Publikováno v:
Metabolites; Volume 13; Issue 7; Pages: 774
Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus
Autor:
Teresa W.-M. Fan, Saeed Daneshmandi, Teresa A. Cassel, Mohammad B. Uddin, James Sledziona, Patrick T. Thompson, Penghui Lin, Richard M. Higashi, Andrew N. Lane
Publikováno v:
The Journal of Immunology. 209:1674-1690
Immunomodulatory (IM) metabolic reprogramming in macrophages (Mϕs) is fundamental to immune function. However, limited information is available for human Mϕs, particularly in response plasticity, which is critical to understanding the variable effi