Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Teresa W-M Fan"'
Publikováno v:
eLife, Vol 10 (2021)
Cellular metabolism has key roles in T cells differentiation and function. CD4+ T helper-1 (Th1), Th2, and Th17 subsets are highly glycolytic while regulatory T cells (Tregs) use glucose during expansion but rely on fatty acid oxidation for function.
Externí odkaz:
https://doaj.org/article/851c6bd2a26549a4b642403b49029a4d
Autor:
L. Leon Dent, Sammed N. Mandape, Siddharth Pratap, Jianan Dong, Jamaine Davis, Jennifer A. Gaddy, Kofi Amoah, Steve Damo, Dana R. Marshall, Jacob Jones, Toni Brandt, Gilberto Diaz, Qingguo Wang, Todd Gary, Ashwini Yenamandra, Marina Z. Ghattas, Marwa Elrakaiby, Ramy K. Aziz, Hamdallah H. Zedan, Moamen Elmassry, Marwa ElRakaiby, Mariam Lotfy, Jarrad Marcel, Rania A. Khattab, Maha M. Abdelfattah, Jack A. Gilbert, Pouya Dini, Shavahn C. Loux, Kirsten E. Scoggin, Alejandro Esteller-Vico, Edward L. Squires, Mats H. T. Troedsson, Peter Daels, Barry A. Ball, Kalpani De Silva, Ernest Bailey, Joel C. Stephens, Theodore S. Kalbfleisch, Christine E. Dolin, Lauren G. Poole, Daniel W. Wilkey, Eric C. Rouchka, Gavin E. Arteel, Michelle T. Barati, Michael L. Merchant, Richard M. Higashi, Teresa W-M Fan, Hunter Moseley, Andrew N Lane
Publikováno v:
BMC Proceedings, Vol 11, Iss S9, Pp 1-6 (2017)
Externí odkaz:
https://doaj.org/article/ba2d821b39b041cdb5b41ff2684d6ca9
Autor:
Eric C. Rouchka, Julia H. Chariker, David A. Tieri, Juw Won Park, Shreedharkumar Rajurkar, Vikas Singh, Nishchal K. Verma, Yan Cui, Mark Farman, Bradford Condon, Neil Moore, Jerzy Jaromczyk, Jolanta Jaromczyk, Daniel Harris, Patrick Calie, Eun Kyong Shin, Robert L. Davis, Arash Shaban-Nejad, Joshua M. Mitchell, Robert M. Flight, Qing Jun Wang, Richard M. Higashi, Teresa W-M Fan, Andrew N. Lane, Hunter N. B. Moseley, Liangqun Lu, Bernie J Daigle, Xi Chen, Andrey Smelter, Jerzy W. Jaromczyk, Li Chen, Bailey K. Phan, Nathaniel J. Serpico, Ethan G. Toney, Caroline E. Melton, Jennifer R. Mandel, Bernie J. Daigle, Hao Chen, Kazi I. Zaman, Ramin Homayouni, Patrick J. Trainor, Samantha M. Carlisle, Andrew P. DeFilippis, Shesh N. Rai
Publikováno v:
BMC Bioinformatics, Vol 18, Iss S9, Pp 1-9 (2017)
Externí odkaz:
https://doaj.org/article/328512aebeaa49129aa4b14e4dcfefe0
Autor:
Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy
Externí odkaz:
https://doaj.org/article/38460ce622de479f9a32204e95da4901
Autor:
Youfeng Yang, Andrew N Lane, Christopher J Ricketts, Carole Sourbier, Ming-Hui Wei, Brian Shuch, Lisa Pike, Min Wu, Tracey A Rouault, Laszlo G Boros, Teresa W-M Fan, W Marston Linehan
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72179 (2013)
Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism. These changes represent multiple biochemical adaptations in glucose and fatty acid metabolis
Externí odkaz:
https://doaj.org/article/bcb80a4501e24a8ea16871e56472b9c3
Publikováno v:
Metabolites, Vol 14, Iss 7, p 383 (2024)
Stable isotope-resolved metabolomics comprises a critical set of technologies that can be applied to a wide variety of systems, from isolated cells to whole organisms, to define metabolic pathway usage and responses to perturbations such as drugs or
Externí odkaz:
https://doaj.org/article/8b3c1301b8e9419f8c21761c958382d2
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Stable Isotope Resolved Metabolomics (SIRM) is a new biological approach that uses stable isotope tracers such as uniformly $$^{13}C$$ 13 C -enriched glucose ( $$^{13}C_6$$ 13 C 6 -Glc) to trace metabolic pathways or networks at t
Externí odkaz:
https://doaj.org/article/afb88728f4aa4c9986218a887a38be08
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/21ff1cd500d64512848bfa051f02263e
Autor:
Kate Brown, Lisa M. Miller Jenkins, Daniel R. Crooks, Deborah R. Surman, Sharlyn J. Mazur, Yuan Xu, Bhargav S. Arimilli, Ye Yang, Andrew N. Lane, Teresa W-M. Fan, David S. Schrump, W. Marston Linehan, R. Taylor Ripley, Ettore Appella
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
TP53 is the most commonly mutated gene in cancer, and gain-of-function mutations have wide-ranging effects. Efforts to reactivate wild-type p53 function and inhibit mutant functions have been complicated by the variety of TP53 mutations. Identified f
Externí odkaz:
https://doaj.org/article/c07b755597a5468588906ab014a43c40
Autor:
Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N. Lane
Publikováno v:
Metabolites, Vol 13, Iss 7, p 774 (2023)
Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus
Externí odkaz:
https://doaj.org/article/d138aeef22d54272a4f32cf81e8a1281