Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Teresa V. Bowman"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2145 (2024)
Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host d
Externí odkaz:
https://doaj.org/article/cb60d540900241a38cedb694c6acb09c
Autor:
Martina Cusan, Haifeng Shen, Bo Zhang, Aijun Liao, Lu Yang, Meiling Jin, Mike Fernandez, Prajish Iyer, Yiming Wu, Kevyn Hart, Catherine Gutierrez, Sara Nik, Shondra M. Pruett-Miller, Jeremy Stark, Esther A. Obeng, Teresa V. Bowman, Catherine J. Wu, Ren-Jang Lin, Lili Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion in B cells, but not either lesion alone, leads to the onset of
Externí odkaz:
https://doaj.org/article/2342ae1271db4cc3a65ea43ea203cc65
Autor:
Keisuke Ito, Teresa V. Bowman
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 1, Pp 5-8 (2022)
Externí odkaz:
https://doaj.org/article/671dc6b60d1e4cc19141b05ef676a3d6
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 337-345 (2021)
Abstract Hematopoietic stem cell transplantation (HSCT) is a treatment for many malignant, congenital, and acquired hematologic diseases. Some outstanding challenges in the HSCT field include the paucity of immunologically‐matched donors, our inabi
Externí odkaz:
https://doaj.org/article/384b676d2f4342debe776360af839e84
Autor:
Bianca A. Ulloa, Samima S. Habbsa, Kathryn S. Potts, Alana Lewis, Mia McKinstry, Sara G. Payne, Julio C. Flores, Anastasia Nizhnik, Maria Feliz Norberto, Christian Mosimann, Teresa V. Bowman
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109703- (2021)
Summary: Hematopoietic stem cells (HSCs) are rare cells that arise in the embryo and sustain adult hematopoiesis. Although the functional potential of nascent HSCs is detectable by transplantation, their native contribution during development is unkn
Externí odkaz:
https://doaj.org/article/ba3c3c98397143fa877fc402aef205f9
Autor:
Adriana De La Garza, Rosannah C. Cameron, Varun Gupta, Ellen Fraint, Sara Nik, Teresa V. Bowman
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2093-2104 (2019)
Abstract: The spliceosomal component Splicing Factor 3B, subunit 1 (SF3B1) is one of the most prevalently mutated factors in the bone marrow failure disorder myelodysplastic syndrome. There is a strong clinical correlation between SF3B1 mutations and
Externí odkaz:
https://doaj.org/article/e73b6be9f7244efab14551a77b164f2b
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
DEAD-box Helicase 41 (DDX41) is a recently identified factor mutated in hematologic malignancies whose function in hematopoiesis is unknown. Using an in vivo model of Ddx41 deficiency, we unveiled a critical role for this helicase in regulating eryth
Externí odkaz:
https://doaj.org/article/4cd34de674f44805b99fb798f4d8b85a
Autor:
Shelly Sorrells, Sara Nik, Mattie Casey, Rosannah C. Cameron, Harold Truong, Cristhian Toruno, Michelle Gulfo, Albert Lowe, Cicely Jette, Rodney A. Stewart, Teresa V. Bowman
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 2 (2018)
RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing
Externí odkaz:
https://doaj.org/article/e528214ab2f54ebfa243703e24f54c74
Autor:
Kathryn S. Potts, Teresa V. Bowman
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Human myeloid malignancies represent a substantial disease burden to individuals, with significant morbidity and death. The genetic underpinnings of disease formation and progression remain incompletely understood. Large-scale human population studie
Externí odkaz:
https://doaj.org/article/2b6830d0ee9f46aaab0e31da244d48ee
Autor:
Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat, Shanisha Gordon-Mitchell, Srabani Sahu, Sanjay Pandey, Nishi Shah, Srinivas Aluri, Ritesh Aggarwal, Sarah Aminov, Leya Schwartz, Violetta Steeples, Robert N Booher, Murali Ramachandra, Maria Samson, Milagros Carbajal, Kith Pradhan, Teresa V Bowman, Manoj M Pillai, Britta Will, Amittha Wickrema, Aditi Shastri, Robert K Bradley, Robert E Martell, Ulrich G Steidl, Evripidis Gavathiotis, Jacqueline Boultwood, Daniel T Starczynowski, Amit Verma
Publikováno v:
eLife, Vol 11 (2022)
Background: Mutations in the SF3B1 splicing factor are commonly seen in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet the specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immun
Externí odkaz:
https://doaj.org/article/530c5c84de264ae68b3135c39fce561b