Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Teresa Urich"'
Autor:
Gayle C. Bosma, Maria G. Cotticelli, Donna M. Fath, Jiyoon Kim, Marko Z. Radic, Teresa Urich, Norman R. Ruetsch, Melvin J. Bosma
Publikováno v:
The Journal of Experimental Medicine
Class switch recombination (CSR), similar to V(D)J recombination, is thought to involve DNA double strand breaks and repair by the nonhomologous end–joining pathway. A key component of this pathway is DNA-dependent protein kinase (DNA-PK), consisti
Autor:
Katie Wachtel, Marcus E. Carr, Katherine A. High, Lisa M. Sullivan, Spencer K. Sullivan, Adam Giermasz, Yifeng Chen, Aline M. Galvão, Linda B. Couto, Alvin Luk, J. Fraser Wright, Jerome M. Teitel, Jonathan M. Ducore, Daniel J. Hui, Adam Cuker, Xavier M. Anguela, Catherine E. McGuinn, Suvankar Majumdar, Daniel Takefman, Lindsey A. George, Teresa Urich
Publikováno v:
Blood. 128:3-3
Background: Earlier data demonstrated long-term expression of factor IX (mean FIX:C ~5.1%) following AAV8-mediated gene transfer at 2 x1012 vg/kg in hemophilia B (Nathwani et al., 2014). While the clinical improvement imparted by stable FIX levels is