Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Teresa Sandoval-Schaefer"'
Autor:
Olivia Justynski, Kate Bridges, Will Krause, Maria Fernanda Forni, Quan M Phan, Teresa Sandoval-Schaefer, Kristyn Carter, Diane E King, Henry C Hsia, Michael I Gazes, Steven D Vyce, Ryan R Driskell, Kathryn Miller-Jensen, Valerie Horsley
Publikováno v:
eLife, Vol 12 (2023)
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition and clearance of apoptotic cells regulate repair are not fully understood. Here
Externí odkaz:
https://doaj.org/article/dbdf124a3b954f59bcd564236e200881
Autor:
Georgios Theocharidis, Beena E. Thomas, Debasree Sarkar, Hope L. Mumme, William J. R. Pilcher, Bhakti Dwivedi, Teresa Sandoval-Schaefer, Ruxandra F. Sîrbulescu, Antonios Kafanas, Ikram Mezghani, Peng Wang, Antonio Lobao, Ioannis S. Vlachos, Biraja Dash, Henry C. Hsia, Valerie Horsley, Swati S. Bhasin, Aristidis Veves, Manoj Bhasin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Diabetic foot ulcers (DFUs) remain a complication of diabetes that are difficult to heal and lead to disability. Here the authors use single-cell RNA-sequencing and spatial transcriptomics to characterize the DFU cellular landscape and identify a pop
Externí odkaz:
https://doaj.org/article/f9eeb6aeee15457486ee4ea3a39b9697
Autor:
Thomas J. Hayman, Marta Baro, Tyler MacNeil, Chatchai Phoomak, Thazin Nwe Aung, Wei Cui, Kevin Leach, Radhakrishnan Iyer, Sreerupa Challa, Teresa Sandoval-Schaefer, Barbara A. Burtness, David L. Rimm, Joseph N. Contessa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The endoplasmic reticulum-localized adaptor STING regulates the innate immune response through its ability to sense DNA damage. Here the authors reveal that STING functions as a regulator of cellular ROS homeostasis and tumor cell susceptibility to r
Externí odkaz:
https://doaj.org/article/7f9f99967a354a5b93d3fe5db608fc2d
Autor:
Barbara Burtness, Ja Seok Koo, Wendell G. Yarbrough, Natalia Issaeva, Erica A. Golemis, Ilya G. Serebriiskii, Jeffrey P. Townsend, Elizabeth B. Perry, Stephen G. Gaffney, Roshan Sharma, Ranee Mehra, Fang Zhu, Dong-hua Yang, Kyung Jin Eoh, Teresa Sandoval-Schaefer, Janaki Parameswaran, Jong Woo Lee
Supplementary Figure S4 related to Figure 5D-F. (A) Individual tumor volume changes in Detroit 562-xenografted mice treated with vehicle, adavosertib (30 mg/kg, daily, p.o.), alisertib (30 mg/kg, daily, p.o.), or the combinations of alisertib with ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6818328270160b4c43eb598ddc2e54
https://doi.org/10.1158/1078-0432.22470468.v1
https://doi.org/10.1158/1078-0432.22470468.v1
Autor:
Barbara Burtness, Ja Seok Koo, Wendell G. Yarbrough, Natalia Issaeva, Erica A. Golemis, Ilya G. Serebriiskii, Jeffrey P. Townsend, Elizabeth B. Perry, Stephen G. Gaffney, Roshan Sharma, Ranee Mehra, Fang Zhu, Dong-hua Yang, Kyung Jin Eoh, Teresa Sandoval-Schaefer, Janaki Parameswaran, Jong Woo Lee
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d753786b37344bc31a31ee5a7076b1d
https://doi.org/10.1158/1078-0432.22470480
https://doi.org/10.1158/1078-0432.22470480
Autor:
Barbara Burtness, Ja Seok Koo, Wendell G. Yarbrough, Natalia Issaeva, Erica A. Golemis, Ilya G. Serebriiskii, Jeffrey P. Townsend, Elizabeth B. Perry, Stephen G. Gaffney, Roshan Sharma, Ranee Mehra, Fang Zhu, Dong-hua Yang, Kyung Jin Eoh, Teresa Sandoval-Schaefer, Janaki Parameswaran, Jong Woo Lee
Purpose:Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but syntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197134f3fb66259dd8520306649b206e
https://doi.org/10.1158/1078-0432.c.6527577.v1
https://doi.org/10.1158/1078-0432.c.6527577.v1
Autor:
Teresa Sandoval-Schaefer, Quan Phan, Biraja C. Dash, Alexandre J. Prassinos, Kaiti Duan, Michael I. Gazes, Steven D. Vyce, Ryan Driskell, Henry C. Hsia, Valerie Horsley
Publikováno v:
bioRxiv
Wound repair requires the coordination of multiple cell types including immune cells and tissue resident cells to coordinate healing and return of tissue function. Diabetic foot ulceration is a type of chronic wound that impacts over 4 million patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ddab7cfd4073161ac178d2606ebcd7
https://europepmc.org/articles/PMC9949055/
https://europepmc.org/articles/PMC9949055/
Autor:
Natalia Issaeva, Dong-Hua Yang, Jeffrey P. Townsend, Ranee Mehra, Stephen G. Gaffney, Elizabeth B. Perry, Kyung Jin Eoh, Janaki Parameswaran, Wendell G. Yarbrough, Fang Zhu, Ja Seok Koo, Teresa Sandoval-Schaefer, Ilya G. Serebriiskii, Roshan Sharma, Jong Woo Lee, Barbara Burtness, Erica A. Golemis
Publikováno v:
Clinical Cancer Research. 25:3430-3442
Purpose: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe17963fac38f0cea7bfdd25aeb8972
https://doi.org/10.1158/1078-0432.ccr-18-0440
https://doi.org/10.1158/1078-0432.ccr-18-0440
Autor:
Wei Cui, David L. Rimm, Kevin Leach, Thazin Nwe Aung, Radhakrishnan P. Iyer, Sreerupa Challa, Barbara Burtness, Thomas J. Hayman, Chatchai Phoomak, Tyler MacNeil, Joseph N. Contessa, Marta Baro, Teresa Sandoval-Schaefer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Resistance to DNA-damaging agents is a significant cause of treatment failure and poor outcomes in oncology. To identify unrecognized regulators of cell survival we performed a whole-genome CRISPR-Cas9 screen using treatment with ionizing radiation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742835bcd26216b89b828bb921aa7025
https://doi.org/10.1038/s41467-021-22572-8
https://doi.org/10.1038/s41467-021-22572-8
Autor:
Biraja C. Dash, Ioannis S. Vlachos, Ruxandra F. Sîrbulescu, Henry C. Hsia, Beena E Thomas, Ikram Mezghani, Teresa Sandoval-Schaefer, Bhakti Dwivedi, Georgios Theocharidis, Manoj Bhasin, Peng Wang, Aristidis Veves, Debasree Sarkar, Antonio Lobao, Valerie Horsley, Swati S Bhasin, William Jr Pilcher, Antonios Kafanas
To understand the diabetic wound healing microenvironment, we profiled 174,962 single cells from foot, forearm, and PBMCs using single-cell RNA sequencing (scRNASeq) approach. Our analysis shows enrichment of a unique population of fibroblasts overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3815fa13e83552c4561976db0eea455a
https://doi.org/10.1101/2021.03.11.434413
https://doi.org/10.1101/2021.03.11.434413