Mll5 is required for normal spermatogenesis.

Autor: Damian B Yap, David C Walker, Leah M Prentice, Steven McKinney, Gulisa Turashvili, Katrin Mooslehner-Allen, Teresa Ruiz de Algara, John Fee, Xavier d'Anglemont de Tassigny, William H Colledge, Samuel Aparicio

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27127 (2011)

Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch of proteins. Recently, constitutive knock out animal studies have shown that Mll5 is r

Externí odkaz: https://doaj.org/article/2896489fe9d34f38bb80962b782ea739

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer

Autor: Allen W. Zhang, Justina Biele, Kieran R Campbell, Jerome Ting, Samuel Aparicio, Nicholas Ceglia, Diljot Grewal, Marc J Williams, Richard D. Moore, Takako Kono, Nicole Rusk, Jennifer Pham, Fatemeh Dorri, Sohrab P. Shah, Beixi Wang, Daniel Lai, Andrew J. Mungall, Peter Eirew, Hak Woo Lee, Mirela Andronescu, Andrew McPherson, Marco A. Marra, Alexandre Bouchard-Côté, Teresa Ruiz de Algara, Ciara H. O'Flanagan, Jazmine Brimhall, Farhia Kabeer, So Ra Lee, Sohrab Salehi, Tehmina Masud, Brian Yu Chieh Cheng

Tumour fitness landscapes underpin selection in cancer, impacting etiology, evolution and response to treatment. Progress in defining fitness landscapes has been impeded by a lack of timeseries perturbation experiments over realistic intervals at sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1fdb04b617c65503083866007893e0

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

Autor: Edward S. Boyden, Elizabeth A. Chavez, Steven S.S. Poon, Robby Becker, Wendy Greenwood, M Jafar Taghiyar, Peter Eirew, Maximillian Lee, Carl L. Hansen, Hans Zahn, Sohrab P. Shah, Mohammad Al Sa’d, Jonas Windager, Maia A. Smith, Lauren Martin, Hsuan Lee, Matt Wiens, So Ra Lee, A. Dariush, Oleg Golovko, Fergus Cafferty, Sorhab Shah, Russell Kunes, Owen Harris, Nick Chornay, Jean Fan, Samuel Aparicio, Marco A. Marra, Shankar Balasubramanian, Stephen Chia, Andrew McPherson, Farhia Kabeer, Samantha Leung, Sophia A Wild, Neil Millar, Claire Mulvey, Shahar Alon, Giorgia Battistoni, Leonardo Sepulveda Duran, Anubhav Sinha, Khanh N. Dinh, Viktoria Bojilova, Yi Cui, Nafis Abrar, Sophia Chan, Yussanne Ma, Austin Smith, Marcel Burger, Jean Hausser, Eduardo Gonzales Solares, Maurizio Callari, Bernd Bodenmiller, Dario Bressan, Aybuke Kupcu Yoldas, Tehmina Masud, Adi Steif, Colin Mar, Abigail Shea, Gregory J. Hannon, Yangguang Li, Timothy M. Chan, Christian Steidl, Cydney B. Nielsen, Flaminia Grimaldi, Eyal Fisher, Daniel J. Da Costa, Tatjana Kovacevic, Carlos Gonzalez-Fernandez, Beixi Wang, Spencer Watson, Sandra Tietscher, Teresa Ruiz, Ignacio Vázquez-García, Jessica Ngo, Amauche Emenari, Pu Zheng, Kirsty Sawicka, Carlos Caldas, Asmamaw T Wassie, Daniel Lai, Chenglong Xia, Oscar M. Rueda, Robin J.N. Coope, Andrew J. Mungall, Fiona Nugent, Marta Paez Ribes, Karen A. Gelmon, Stephen Pleasance, Simon Tavaré, Pascale Walters, Teresa Ruiz de Algara, Ciara H. O'Flanagan, Curtis Huebner, Emma Laks, T. Michael Underhill, Jazmine Brimhall, Alastair Marti, Justina Biele, R. Wilder Scott, Diljot Grewal, Fatime Qosaj, Richard D. Moore, Dan Goodwin, Laura Kuett, Nicolas A. Walton, Suvi Harris, Emmanouil D. Karagiannis, Cristina Jauset, Elena Williams, Isabella Pearsall, Sara Vogl, Alejandra Bruna, Yaniv Lubling, Jerome Ting, Ian G. Cannell, Xiaowei Zhuang, Richard Corbett, Hannah Casbolt, Giulia Lerda, Johanna A. Joyce, Spencer Vatrt-Watts

Publikováno v: Elsevier
Cell

Summary Accurate measurement of clonal genotypes, mutational processes, and replication states from individual tumor-cell genomes will facilitate improved understanding of tumor evolution. We have developed DLP+, a scalable single-cell whole-genome s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93887a330b47f0bff283dbfe67150265
https://pubmed.ncbi.nlm.nih.gov/31907478

Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

Autor: Samuel Aparicio, Steven McKinney, Damian B. Yap, Teresa Ruiz de Algara, John Dixon, Mark B. L. Carlton, Rosemary Thresher, R. Keith Humphries, Alaeddin Tafech, Bill Colledge, Michael Heuser, Malina Leung

Publikováno v: Blood. 113:1432-1443

MLL5 is a divergent member of the Drosophila Trithorax-related (SET) domain and plant homeodomain (PHD) domain-containing chromatin regulators that are involved in the regulation of transcriptional “memory” during differentiation. Human MLL5 is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2c785228faf50d521e51f28c07776d7
https://doi.org/10.1182/blood-2008-06-162263

Identification of transcripts with enriched expression in the developing and adult pancreas

Autor: Cheryl D. Helgason, Bogard Zavaglia, Teresa Ruiz de Algara, Steven J.M. Jones, Joy Witzsche, Brad G. Hoffman, Marco A. Marra, Mike Beach, Pamela A. Hoodless

Publikováno v: Genome Biology

The expression profile of different developmental stages of the murine pancreas and predictions of transcription factor interactions, provides a framework for pancreas regulatory networks and development.
Background Despite recent advances, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2898b70de8a873f320ced94c4e8c18
https://pubmed.ncbi.nlm.nih.gov/18554416