Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Teresa Rodriguez-Martin"'
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pa
Externí odkaz:
https://doaj.org/article/4ad5ef18337243a28630ef613a282fa8
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice
Autor:
Brian H. Anderton, Laura Sturdee, Michael P. Coleman, Jean Pierre Brion, Diane P. Hanger, Jonathan Gilley, Teresa Rodriguez-Martin, Amy M. Pooler, Kunie Ando, Anjan Seereeram
Publikováno v:
Neurobiology of aging, 39
Gilley, J, Ando, K, Seereeram, A, Rodríguez-Martín, T, Pooler, A M, Sturdee, L, Anderton, B H, Brion, J-P, Hanger, D P & Coleman, M P 2016, ' Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice ', Neurobiology of Aging, vol. 39, pp. 1-18 . https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Gilley, J, Ando, K, Seereeram, A, Rodríguez-Martín, T, Pooler, A M, Sturdee, L, Anderton, B H, Brion, J-P, Hanger, D P & Coleman, M P 2016, ' Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice ', Neurobiology of Aging, vol. 39, pp. 1-18 . https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. To investigate the involvement of tau phosphorylation in the pathological process, we generated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd259b2f04784efb0849659337928c3
https://doi.org/10.1016/j.neurobiolaging.2015.11.028
https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Publikováno v:
Acta Neuropathologica Communications
Guo, T, Dakkak, D, Rodriguez-Martin, T, Noble, W J & Hanger, D P 2019, ' A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response ', Acta Neuropathologica Communications, vol. 7, no. 2, pp. 1-15 . https://doi.org/10.1186/s40478-018-0651-9
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Guo, T, Dakkak, D, Rodriguez-Martin, T, Noble, W J & Hanger, D P 2019, ' A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response ', Acta Neuropathologica Communications, vol. 7, no. 2, pp. 1-15 . https://doi.org/10.1186/s40478-018-0651-9
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6e6ab426e5b753fc715f16a8d34dec88
https://pubmed.ncbi.nlm.nih.gov/30606258
https://pubmed.ncbi.nlm.nih.gov/30606258
Autor:
Mariano A. Garcia-Blanco, Karen Anthony, Teresa Rodriguez-Martin, Jean-Marc Gallo, S. Gary Mansfield, Brian H. Anderton
Publikováno v:
Human Molecular Genetics
Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by mutations in the MAPT gene, encoding the tau protein that accumulates in intraneuronal lesions in a number of neurodegenerative diseases. Several FTDP-17 mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc2a4b92fde0aae670b58500bdc4ac
http://europepmc.org/articles/PMC2722988
http://europepmc.org/articles/PMC2722988
Autor:
Paul J. Chapple, Arvind Dev, Karen Anthony, Teresa Rodriguez Martin, Jean-Marc Gallo, Thomas A. Cooper
Publikováno v:
Human Molecular Genetics. 16:2760-2769
Elucidating the mechanisms of alternative splicing in the brain is a prerequisite to the understanding of the pathogenesis of major neurological diseases linked to impairment of pre-mRNA alternative splicing. The gene trinucleotide repeat-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61889ed8f34c803d1f0e4954eb92b67
https://doi.org/10.1093/hmg/ddm233
https://doi.org/10.1093/hmg/ddm233
Autor:
Andrew J. Grierson, James Connell, Peter L. Lantos, G M Gibb, Diane P. Hanger, Teresa Rodriguez-Martin, N.M. Kahn, Jean-Marc Gallo, Tamas Revesz, Brian H. Anderton
Publikováno v:
Molecular Brain Research. 137:104-109
A number of neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by intraneuronal accumulation of the tau protein. Some forms of FTDP-17 are caused by mutations in the tau gene affecting exon 10 splicing. Therefore, dysre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed15148ebb0885040d91d2028b52ad0f
https://doi.org/10.1016/j.molbrainres.2005.02.014
https://doi.org/10.1016/j.molbrainres.2005.02.014
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Human Molecular Genetics
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Human Molecular Genetics
Abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including Alzheimer's disease. Aberrant alternative splicing of exon 10 in the tau pre-mRNA resulting in an imbalance of tau isoforms is one of the molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a826d6ddf973419e0898c9512cfb58
http://hmg.oxfordjournals.org/content/22/13/2603.long
http://hmg.oxfordjournals.org/content/22/13/2603.long
Autor:
Mariano A. Garcia-Blanco, Mike Hutton, S. Gary Mansfield, Jean-Marc Gallo, Teresa Rodriguez-Martin, Qingming Yu, Jianhua Zhou, Brian H. Anderton, Andrew Grover
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(43)
Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by mutations in the gene encoding the microtubule-associated protein, tau. Some FTDP-17 mutations affect exon 10 splicing. To correct aberrant exon 10 splicing whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4ba6b6c9f77d33707b6114d4f75bc6
https://pubmed.ncbi.nlm.nih.gov/16230627
https://pubmed.ncbi.nlm.nih.gov/16230627
Autor:
Roberto Bianchi, Teresa Rodriguez Martin, José Luis Galbete, Gianluigi Forloni, Piergiorgio Modena, Elisa Peressini
Cerebral deposits of β-amyloid (βA) are a major feature in Alzheimer's disease. βA is derived from amyloid precursor protein (APP). APP is subject to N- and O-glycosylation and undergoes a series of proteolytic cleavages that lead to the release o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eec4025ca358ddc0d406d6ca5af2277
https://europepmc.org/articles/PMC1221067/
https://europepmc.org/articles/PMC1221067/
Autor:
Teresa Rodriguez-Martin, Andrew Grover, Mariano A. Garcia-Blanco, Jean-Marc Gallo, Mike Hutton, Gary S. Manfield, Brian H. Anderton
Publikováno v:
Neurobiology of Aging. 25:S261
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd02819d773bbadee83f32d615a0275f
https://doi.org/10.1016/s0197-4580(04)80874-1
https://doi.org/10.1016/s0197-4580(04)80874-1