The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families

Autor: Maartje A.C. Schreurs, Teresa Ramón y Cajal, Muriel A. Adank, J. Margriet Collée, Antoinette Hollestelle, Jeroen van Rooij, Marjanka K. Schmidt, Maartje J. Hooning

Publikováno v: Breast, Vol 75, Iss , Pp 103724- (2024)

To determine the changes in surveillance category by adding a polygenic risk score based on 311 breast cancer (BC)-associated variants (PRS311), questionnaire-based risk factors and breast density on personalized BC risk in unaffected women from Dutc

Externí odkaz: https://doaj.org/article/8cae6176491f451393a17d4da44b06c7

p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study

Autor: Martin Köbel, Eun‐Young Kang, Ashley Weir, Peter F Rambau, Cheng‐Han Lee, Gregg S Nelson, Prafull Ghatage, Nicola S Meagher, Marjorie J Riggan, Jennifer Alsop, Michael S Anglesio, Matthias W Beckmann, Christiani Bisinotto, Michelle Boisen, Jessica Boros, Alison H Brand, Angela Brooks‐Wilson, Michael E Carney, Penny Coulson, Madeleine Courtney‐Brooks, Kara L Cushing‐Haugen, Cezary Cybulski, Suha Deen, Mona A El‐Bahrawy, Esther Elishaev, Ramona Erber, Sian Fereday, AOCS Group, Anna Fischer, Simon A Gayther, Arantzazu Barquin‐Garcia, Aleksandra Gentry‐Maharaj, C Blake Gilks, Helena Gronwald, Marcel Grube, Paul R Harnett, Holly R Harris, Andreas D Hartkopf, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y Hernandez, Yajue Huang, Anna Jakubowska, Mercedes Jimenez‐Linan, Michael E Jones, Catherine J Kennedy, Tomasz Kluz, Jennifer M Koziak, Jaime Lesnock, Jenny Lester, Jan Lubiński, Teri A Longacre, Maria Lycke, Constantina Mateoiu, Bryan M McCauley, Valerie McGuire, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Paz‐Ares, Teresa Ramón y Cajal, Joseph H Rothstein, Matthias Ruebner, Minouk J Schoemaker, Mitul Shah, Raghwa Sharma, Mark E Sherman, Yurii B Shvetsov, Naveena Singh, Helen Steed, Sarah J Storr, Aline Talhouk, Nadia Traficante, Chen Wang, Alice S Whittemore, Martin Widschwendter, Lynne R Wilkens, Stacey J Winham, Javier Benitez, Andrew Berchuck, David D Bowtell, Francisco J Candido dos Reis, Ian Campbell, Linda S Cook, Anna DeFazio, Jennifer A Doherty, Peter A Fasching, Renée T Fortner, María J García, Marc T Goodman, Ellen L Goode, Jacek Gronwald, David G Huntsman, Beth Y Karlan, Linda E Kelemen, Stefan Kommoss, Nhu D Le, Stewart G Martin, Usha Menon, Francesmary Modugno, Paul DP Pharoah, Joellen M Schildkraut, Weiva Sieh, Annette Staebler, Karin Sundfeldt, Anthony J Swerdlow, Susan J Ramus, James D Brenton

Publikováno v: The Journal of Pathology: Clinical Research, Vol 9, Iss 3, Pp 208-222 (2023)

Abstract Our objective was to test whether p53 expression status is associated with survival for women diagnosed with the most common ovarian carcinoma histotypes (high‐grade serous carcinoma [HGSC], endometrioid carcinoma [EC], and clear cell carc

Externí odkaz: https://doaj.org/article/493c5874781345c8971b7e798d52a02b

Cell Senescence-Related Pathways Are Enriched in Breast Cancer Patients With Late Toxicity After Radiotherapy and Low Radiation-Induced Lymphocyte Apoptosis

Autor: Ester Aguado-Flor, María J. Fuentes-Raspall, Ricardo Gonzalo, Carmen Alonso, Teresa Ramón y Cajal, David Fisas, Alejandro Seoane, Álex Sánchez-Pla, Jordi Giralt, Orland Díez, Sara Gutiérrez-Enríquez

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundRadiation-induced late effects are a common cause of morbidity among cancer survivors. The biomarker with the best evidence as a predictive test of late reactions is the radiation-induced lymphocyte apoptosis (RILA) assay. We aimed to inves

Externí odkaz: https://doaj.org/article/7c6649b3bb71437fb465a5121872248c

MicroRNA-1291 Is Associated With Locoregional Metastases in Patients With Early-Stage Breast Cancer

Autor: Daniel Escuin, Laura López-Vilaró, Olga Bell, Josefina Mora, Antonio Moral, José Ignacio Pérez, Cristina Arqueros, Teresa Ramón y Cajal, Enrique Lerma, Agustí Barnadas

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Evidence that microRNAs (miRNAs) regulate the various steps of metastasis is increasing. Several studies have looked at the miRNA expression profile in primary breast tumors but few have compared primary tumor and sentinel lymph node (SLN) metastasis

Externí odkaz: https://doaj.org/article/7b2626ae3d964deaa6751f0bd6488ccd

Frequency of breast cancer with hereditary risk features in Spain: Analysis from GEICAM 'El Álamo III' retrospective study.

Autor: Iván Márquez-Rodas, Marina Pollán, María José Escudero, Amparo Ruiz, Miguel Martín, Ana Santaballa, Purificación Martínez Del Prado, Norberto Batista, Raquel Andrés, Antonio Antón, Antonio Llombart, Antonio Fernandez Aramburu, Encarnación Adrover, Sonia González, Miguel Angel Seguí, Lourdes Calvo, José Lizón, Álvaro Rodríguez Lescure, Teresa Ramón Y Cajal, Gemma Llort, Carlos Jara, Eva Carrasco, Sara López-Tarruella

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0184181 (2017)

To determine the frequency of breast cancer (BC) patients with hereditary risk features in a wide retrospective cohort of patients in Spain.a retrospective analysis was conducted from 10,638 BC patients diagnosed between 1998 and 2001 in the GEICAM r

Externí odkaz: https://doaj.org/article/2d7a4a9699d44bcab267ca288b787a05