A blocking antibody against canine CSF-1R maturated by limited CDR mutagenesis

Autor: Ted R. Hupp, David J. Argyle, Bořivoj Vojtěšek, Max Ingberman, Louise M Imamura, Breno C.B. Beirão, Teresa P Raposo

Publikováno v: Antibody Therapeutics
Beirão, B C B, Raposo, T P, Imamura, L M, Ingberman, M, Hupp, T, Vojtěšek, B & Argyle, D J 2020, ' A blocking antibody against canine CSF-1R maturated by limited CDR mutagenesis ', Antibody therapeutics, vol. 3, no. 3, pp. 193-204 . https://doi.org/10.1093/abt/tbaa018

CSF-1R is a receptor mostly associated with the mononuclear phagocytic system. However, its expression within tumors has been linked with poor prognosis in both humans and dogs. Accordingly, several reports have demonstrated the beneficial effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec22e54ff8b729c12bf8c23805cb17f
http://europepmc.org/articles/PMC7990251

The Dog as a Model to Study the Tumor Microenvironment

Autor: Maria I, Carvalho, Teresa P, Raposo, Ricardo, Silva-Carvalho, Isabel, Pires, Justina, Prada, Hugo, Gregório, Felisbina L, Queiroga

Publikováno v: Advances in experimental medicine and biology. 1329

Cancer is a complex and dynamic disease with an outcome that depends on a strict crosstalk between tumor cells and other components in tumor microenvironment, namely, tumor-infiltrating immune cells, fibroblasts, cancer stem cells, adipocytes, and en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e02ce8eae55ddd5dd0970f7e0622893
https://pubmed.ncbi.nlm.nih.gov/34664237

N-glycosylation of CD24 mediates cell motility but inhibits cell proliferation in colorectal cancer

Autor: Mohammad Ilyas, William Dalleywater, Abdullah Alsulaiman, Zaki Hakami, Hassan Otifi, Karin Garrie, Charlotte Horobin, Teresa P Raposo

CD24 confers features of stemness and enhances cell motility in colorectal cancer. It contains numerous O-glycosylation sites but just two putative N-glycosylation sites. The study aimed to mutate N-glycosylation as it thought to be important in medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::308d18f025e1d4e3face4227dfef1abf
https://doi.org/10.1101/2021.05.02.442315

Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion

Autor: Somaia Elsheikh, Catherine Fielden, Mohammad Ilyas, Shaimaa Elsaid Lashin, Philip S. Rudland, Ilias Kouzoukakis, Wei Li, Mohammed A. Aleskandarany, Wakkas Fadhil, Poulam M. Patel, Mohamed El-Tanani, Nadia Said Badawy Khair, Teresa P Raposo

Publikováno v: Journal of clinical pathology. 75(1)

AimsRan GTPase is involved in nucleocytoplasmic shuttling of proteins and is overexpressed in several cancers. The expression of Ran in malignant melanoma (MM) and its functional activity have not been described and were investigated in this study.Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83286708b2f6cbd879082bc2c39548b
https://pubmed.ncbi.nlm.nih.gov/33234696

TGFβ1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer

Autor: Mohammad Ilyas, Abdulaziz Asiri, Teresa P Raposo, Abdulaziz Alfahed

Publikováno v: International Journal of Experimental Pathology. 99:323-330

Cten (C‐terminal tensin‐like) is a member of the tensin protein family found in complex with integrins at focal adhesions. It promotes epithelial‐mesenchymal transition (EMT) and cell motility. The precise mechanisms regulating Cten are unknown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cc7099ccb96faa3791d6d02ad58f0d
https://doi.org/10.1111/iep.12300