Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Teresa Owen"'
Autor:
Wen Sun, Nida Meednu, Alexander Rosenberg, Javier Rangel-Moreno, Victor Wang, Jason Glanzman, Teresa Owen, Xichao Zhou, Hengwei Zhang, Brendan F. Boyce, Jennifer H. Anolik, Lianping Xing
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
B cells contribute to rheumatoid arthritis pathogenesis and bone erosion, but the underlying mechanisms are still unclear. Here the authors show, using mouse models and patient tissues, that B cells directly inhibit osteoblast differentiation by prod
Externí odkaz:
https://doaj.org/article/879bcc165f4342d5914461b4c9efd208
Autor:
Diana G Adlowitz, Jennifer Barnard, Jamie N Biear, Christopher Cistrone, Teresa Owen, Wensheng Wang, Arumugam Palanichamy, Ezinma Ezealah, Debbie Campbell, Chungwen Wei, R John Looney, Inaki Sanz, Jennifer H Anolik
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128269 (2015)
Although B cell depletion therapy (BCDT) is effective in a subset of rheumatoid arthritis (RA) patients, both mechanisms and biomarkers of response are poorly defined. Here we characterized abnormalities in B cell populations in RA and the impact of
Externí odkaz:
https://doaj.org/article/177c96837fef4fe39b5732762f92cefb
Autor:
Javier Rangel‐Moreno, Maria de la Luz Garcia‐Hernandez, Teresa Owen, Jennifer Barnard, Enrique Becerril‐Villanueva, Trinayan Kashyap, Christian Argueta, Armando Gamboa‐Dominguez, Sharon Tamir, Yosef Landesman, Bruce I. Goldman, Christopher T. Ritchlin, Jennifer H. Anolik
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 74(8)
To investigate the hypothesis that selective inhibitors of nuclear export (SINE compounds), recently approved for treatment of refractory plasma cell (PC) malignancy, may have potential in the treatment of lupus.Female NZB/NZW mice were treated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd6f2ac8e41543687d3ccdcf2f38daf
https://pubmed.ncbi.nlm.nih.gov/35333447
https://pubmed.ncbi.nlm.nih.gov/35333447
Autor:
Bruce I. Goldman, Javier Rangel-Moreno, Teresa Owen, Jesi Y. To, Alan V. Smrcka, Jennifer H. Anolik
Publikováno v:
Arthritis & Rheumatology. 68:2244-2256
Objective Despite considerable advances in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for new and more targeted treatment approaches. We previously demonstrated that small-molecule blockade of G protein β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faf62db31588fae748b0e1baa2c17264
https://doi.org/10.1002/art.39673
https://doi.org/10.1002/art.39673
Autor:
Teresa Owen, Christopher Cistrone, Wen Sun, Jennifer H. Anolik, Nida Meednu, Javier Rangel-Moreno, Hengwei Zhang, Victor Wang, Lianping Xing
Publikováno v:
Arthritis & Rheumatology. 68:805-816
Objective Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage. The mechanisms of bone damage in RA are complex, involving activation of bone-resorbing osteoclasts (OCs) by synoviocytes and Th17 cells. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c515ac9b22a1b2cdfd014671a6a6ad68
https://doi.org/10.1002/art.39489
https://doi.org/10.1002/art.39489
Autor:
Alexander F. Rosenberg, Nida Meednu, Chungwen Wei, Teresa Owen, Mariana J. Kaplan, Anna K. Bird, Alfred Rabinovich, Srilakshmi Yalavarthi, Jane L. Liesveld, Jennifer Barnard, Russell Dedrick, Sarah Nevarez, Emily C. Baechler, Jason W. Bauer, Jason S. Knight, Jennifer H. Anolik, Arumugam Palanichamy, Javier Rangel-Moreno, Christopher Cistrone, Iñaki Sanz
Publikováno v:
The Journal of Immunology. 192:906-918
Inappropriate activation of type I IFN plays a key role in the pathogenesis of autoimmune disease, including systemic lupus erythematosus (SLE). In this study, we report the presence of IFN activation in SLE bone marrow (BM), as measured by an IFN ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fd73bf908bdafd20202fd5f22e2355
https://doi.org/10.4049/jimmunol.1302112
https://doi.org/10.4049/jimmunol.1302112
Autor:
Jonathan W. Friedberg, Teresa Owen, Jennifer Barnard, Bo Zheng, Richard I. Fisher, Jennifer H. Anolik, Iñaki Sanz, Jennifer A. Kelly, Emily Cushing, Eric C. B. Milner
Publikováno v:
Clinical Immunology. 122:139-145
The long-term immunologic effects of B cell depletion with rituximab and the characteristics of the reconstituting B cell pool in lymphoma patients are not well defined, despite the widespread usage of this therapy. Here we report that during the B c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8ee6dd8cd5eae99bfdf544f40362e6
https://doi.org/10.1016/j.clim.2006.08.009
https://doi.org/10.1016/j.clim.2006.08.009
Autor:
Iñaki Sanz, Jennifer H. Anolik, Bo Zheng, Teresa Owen, R. John Looney, Sunil Kemshetti, Jennifer Barnard
Publikováno v:
Arthritis & Rheumatism. 56:3044-3056
Objective Recent data suggest that the reconstituting peripheral B cell compartment after B cell depletion therapy may be functionally immature, with a preponderance of transitional B cells and a paucity of memory B cells. This study was undertaken t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4661056ef1a063eb02747fd54294a04a
https://doi.org/10.1002/art.22810
https://doi.org/10.1002/art.22810
Publikováno v:
The FASEB Journal. 29
Systemic Lupus Erythematosus (SLE) is an autoimmune disease with widespread inflammation. A significant contributor to SLE is the excessive recruitment and activation of immune cells to inflamed si...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838bce01f27a612acb8a6dfc82a16773
https://doi.org/10.1096/fasebj.29.1_supplement.618.4
https://doi.org/10.1096/fasebj.29.1_supplement.618.4
Autor:
Nida, Meednu, Hengwei, Zhang, Teresa, Owen, Wen, Sun, Victor, Wang, Christopher, Cistrone, Javier, Rangel-Moreno, Lianping, Xing, Jennifer H, Anolik
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 68(4)
Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage. The mechanisms of bone damage in RA are complex, involving activation of bone-resorbing osteoclasts (OCs) by synoviocytes and Th17 cells. This study was unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ad236a73fb6d1dfbff1f8a5235d7b8c
https://pubmed.ncbi.nlm.nih.gov/26554541
https://pubmed.ncbi.nlm.nih.gov/26554541